Jose Altuve has the most career runs by an active second baseman, with 1,156 runs.

	NAME	R	G	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Jose Altuve J. Altuve	1,156	1,821	7,293	2,232	431	31	229	812	600	76	1,030	315	90	8,042	3,412	691	26	47	45	195	.306	.363	.468	.831	1217	279.7	.357	130	284.1
2	DJ LeMahieu	735	1,300	4,839	1,454	230	36	95	535	415	23	782	87	43	5,349	2,041	361	35	37	22	146	.300	.356	.422	.778	723	95.2	.337	101	8.7
3	Ozzie Albies O. Albies	568	907	3,627	975	216	31	146	523	264	31	664	89	20	3,957	1,691	393	2	33	10	34	.269	.321	.466	.787	538	61.8	.334	107	37.5
4	Marcus Semien M. Semien	450	680	2,759	699	138	13	125	373	270	15	510	63	16	3,065	1,238	276	0	21	3	33	.253	.321	.449	.770	410	47	.332	112	45.9
5	Adam Frazier A. Frazier	402	914	2,978	771	155	21	54	285	242	43	449	45	27	3,295	1,130	230	20	12	9	45	.259	.322	.379	.702	374	-22.3	.307	93	-25.8
6	Ketel Marte K. Marte	349	634	2,308	620	134	26	89	306	260	23	424	27	6	2,616	1,073	249	1	24	15	53	.269	.345	.465	.810	381	71.4	.347	119	61.4
7	Brandon Lowe B. Lowe	347	643	2,275	552	108	12	130	380	253	34	706	31	4	2,576	1,074	250	0	14	6	24	.243	.326	.472	.798	366	55.6	.341	123	71.1
8	Gleyber Torres G. Torres	310	598	2,230	592	102	4	92	300	221	16	494	37	16	2,495	978	198	4	24	5	47	.265	.333	.439	.771	336	42.1	.334	116	46.6
9	Jonathan India J. India	308	523	1,905	482	101	6	63	229	234	68	469	42	11	2,228	784	170	3	18	2	47	.253	.352	.412	.764	307	42.4	.336	107	20.3
10	Jeff McNeil J. McNeil	291	626	2,188	612	120	14	42	220	160	53	281	29	2	2,422	886	176	8	13	4	30	.280	.342	.405	.747	313	26.3	.327	111	31.6
11	Tommy Edman T. Edman	274	479	1,808	468	101	12	45	184	125	20	308	91	13	1,971	728	158	6	12	4	24	.259	.312	.403	.715	228	-6.2	.310	98	-6.8
12	Nico Hoerner N. Hoerner	233	427	1,593	441	83	6	16	160	130	33	210	89	20	1,770	584	105	1	13	4	26	.277	.341	.367	.708	210	-1.7	.314	100	-0.9
13	Jorge Polanco J. Polanco	232	454	1,682	412	80	2	79	247	191	13	438	22	11	1,901	733	161	0	15	3	26	.245	.324	.436	.760	250	24.4	.329	114	30.8
14	Cavan Biggio C. Biggio	231	445	1,308	295	68	3	44	159	214	26	429	29	2	1,556	501	115	3	5	0	5	.226	.344	.383	.728	199	9.6	.323	105	11
15	Javier Báez J. Báez	230	475	1,572	441	89	12	72	249	78	17	443	44	17	1,683	770	173	8	8	27	28	.281	.320	.490	.810	228	28.4	.338	110	19.7
16	Brendan Rodgers B. Rodgers	226	477	1,761	465	95	8	46	207	119	19	418	1	1	1,910	714	149	1	10	1	55	.264	.316	.405	.721	227	2	.314	86	-34.1
17	Andrés Giménez A. Giménez	223	487	1,759	458	80	9	44	204	102	64	347	89	15	1,949	688	133	11	13	8	31	.260	.322	.391	.713	228	-1	.312	103	6.2
18	Jake Cronenworth J. Cronenworth	215	376	1,361	349	80	14	44	184	151	28	260	10	4	1,555	589	138	3	12	9	14	.256	.340	.433	.773	212	27.2	.334	117	32.2
19	Thairo Estrada T. Estrada	197	417	1,459	364	66	6	41	173	69	34	319	51	15	1,573	565	113	2	9	1	29	.249	.297	.387	.685	167	-19.5	.298	91	-16.7
20	Luis García Jr. L. García Jr.	184	406	1,436	382	72	7	38	171	80	2	237	38	12	1,532	582	117	1	13	4	33	.266	.303	.405	.708	172	-12.1	.305	92	-15.4
21	Nicky Lopez N. Lopez	182	517	1,607	372	62	12	5	109	128	17	262	25	18	1,781	473	79	27	2	0	20	.231	.295	.294	.589	140	-73.3	.265	64	-77.1
22	Donovan Solano D. Solano	177	551	1,690	476	82	7	23	175	109	22	325	13	4	1,849	641	112	13	15	6	35	.282	.331	.379	.710	209	-5.1	.311	95	-7.9
23	Bryson Stott B. Stott	162	332	1,217	322	55	6	28	136	104	11	222	70	6	1,351	473	89	1	18	2	19	.265	.324	.389	.712	158	-3.5	.311	96	-6.6
24	Luis Rengifo L. Rengifo	156	394	1,330	332	56	11	41	139	112	15	280	17	12	1,468	533	108	4	7	0	22	.250	.314	.401	.714	170	-6.7	.311	96	-8.5
25	Nolan Gorman N. Gorman	155	337	1,120	246	50	0	61	170	127	6	425	15	4	1,260	479	111	0	7	3	10	.220	.301	.428	.728	151	2.3	.315	102	2.8