Ryan Weber and Alec Bettinger were tied for giving up the most earned runs in a game in 2021, with 11 earned runs.

Interpreted as:

most er by a pitcher in a regular-season game 2021

	NAME	ER	DATE	TM		OPP	DEC	GS	ERA	SO	CG	SHO	SV	IP	H	R	HR	BB	HBP	GF	IBB	TBF	WP
1	Ryan Weber R. Weber	11	6/13/2021	BOS	vs	TOR		0	17.47	7	0	0	0	5.2	13	11	4	2	0	0	0	30	0
2	Alec Bettinger A. Bettinger	11	5/2/2021	MIL	vs	LAD	L	1	24.75	0	0	0	0	4.0	11	11	2	2	1	0	0	26	1
3	Josh Fleming J. Fleming	10	8/11/2021	TBR	@	BOS	L	1	27.00	3	0	0	0	3.1	11	10	0	6	0	0	2	26	0
4	Sandy Alcantara S. Alcantara	10	8/6/2021	MIA	@	COL	L	1	24.55	1	0	0	0	3.2	10	10	3	2	1	0	0	24	0
5	Jerad Eickhoff J. Eickhoff	10	7/27/2021	NYM	vs	ATL	L	1	27.00	4	0	0	0	3.1	7	10	3	5	1	0	1	23	0
6	Mike Foltynewicz M. Foltynewicz	10	7/18/2021	TEX	@	TOR	L	1	54.00	0	0	0	0	1.2	8	10	4	2	0	0	0	15	0
7	Carlos Martinez C. Martinez	10	6/2/2021	STL	@	LAD	L	1	135.00	1	0	0	0	0.2	6	10	0	4	0	0	0	12	0
8	Anthony DeSclafani A. DeSclafani	10	5/23/2021	SFG	vs	LAD	L	1	33.75	3	0	0	0	2.2	9	10	1	3	0	0	1	19	0
9	Joe Ross J. Ross	10	4/19/2021	WSH	vs	STL	L	1	20.77	5	0	0	0	4.1	8	10	4	3	1	0	1	24	0
10	Tyler Anderson T. Anderson	9	9/25/2021	SEA	@	LAA	L	1	40.50	0	0	0	0	2.0	9	9	1	1	0	0	0	15	0
11	Andrew Albers A. Albers	9	9/4/2021	MIN	@	TBR	L	1	27.00	2	0	0	0	3.0	10	9	4	1	0	0	1	20	0
12	Griffin Jax G. Jax	9	8/24/2021	MIN	@	BOS	L	1	17.36	4	0	0	0	4.2	7	9	3	4	0	0	0	25	1
13	Logan Gilbert L. Gilbert	9	8/21/2021	SEA	@	HOU	L	1	17.36	5	0	0	0	4.2	8	9	2	1	0	0	0	23	1
14	Kyle Hendricks K. Hendricks	9	8/12/2021	CHC	vs	MIL	L	1	20.25	3	0	0	0	4.0	11	9	2	1	1	0	0	25	0
15	J.A. Happ	9	7/28/2021	MIN	vs	DET	L	1	27.00	2	0	0	0	3.0	10	9	0	4	0	0	0	23	0
16	Caleb Smith C. Smith	9	7/10/2021	ARI	@	LAD	L	1	81.00	1	0	0	0	1.0	6	9	3	3	0	0	0	12	0
17	Matt Manning M. Manning	9	6/28/2021	DET	@	CLE	L	1	22.09	2	0	0	0	3.2	9	9	2	0	1	0	0	21	0
18	Mike Minor M. Minor	9	6/25/2021	KCR	@	TEX	L	1	16.20	2	0	0	0	5.0	11	9	0	2	0	0	0	27	0
19	Tyler Anderson T. Anderson	9	5/21/2021	PIT	@	ATL	L	1	16.20	7	0	0	0	5.0	10	9	3	2	0	0	0	27	0
20	J.A. Happ	9	5/12/2021	MIN	@	CWS	L	1	24.30	3	0	0	0	3.1	9	9	1	2	0	0	0	20	1
21	Austin Gomber A. Gomber	9	4/26/2021	COL	@	SFG	L	1	48.60	3	0	0	0	1.2	7	9	0	4	0	0	2	16	0
22	Patrick Corbin P. Corbin	9	4/15/2021	WSH	vs	ARI	L	1	40.50	1	0	0	0	2.0	6	10	3	4	2	0	0	19	0
23	Yu Darvish Y. Darvish	8	9/13/2021	SDP	@	SFG	L	1	18.00	3	0	0	0	4.0	6	8	4	3	0	0	0	21	0
24	Glenn Otto G. Otto	8	9/10/2021	TEX	@	OAK	L	1	21.60	5	0	0	0	3.1	8	8	0	1	2	0	0	20	0
25	Kyle Gibson K. Gibson	8	9/3/2021	PHI	@	MIA	L	1	13.50	4	0	0	0	5.1	8	8	1	2	0	0	1	24	0