Between the 1876 and 2022 seasons, the Chicago Cubs had the most games by a team, with 21,931 games.

Interpreted as:

most regular-season games by team 1876 to 2022

	TEAM	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	21,931	.513	11,161	10,609	750,628	100,865	196,742	33,144	7,288	14,818	86,531	67,273	5,124	101,919	15,449	2,996	838,813	288,916	55,250	12,989	2,799	3,485	9,758	.262	.326	.385	.711
2	Braves	21,893	.502	10,921	10,818	749,606	97,666	194,711	31,476	6,257	14,485	84,782	66,317	4,928	96,996	13,866	3,011	836,307	282,156	52,218	12,668	2,788	3,620	10,106	.260	.323	.376	.699
3	Reds	21,515	.504	10,775	10,601	733,319	96,508	191,308	31,778	7,488	13,900	85,733	65,487	5,309	98,889	17,717	3,298	819,861	279,762	53,166	12,622	2,956	3,627	9,503	.261	.325	.382	.706
4	Pirates	21,474	.501	10,687	10,647	735,833	95,659	194,027	31,773	8,879	11,900	85,223	63,112	5,394	96,213	15,410	3,198	819,994	279,258	52,552	12,515	3,017	3,668	9,818	.264	.325	.380	.705
5	Giants	21,399	.536	11,382	9,854	730,562	99,084	192,492	30,753	6,987	15,187	88,622	67,098	5,529	96,227	16,366	3,096	817,737	282,780	52,927	11,631	2,917	3,980	9,924	.263	.329	.387	.716
6	Phillies	21,324	.473	10,022	11,187	729,658	94,533	190,047	32,765	6,618	13,724	84,827	66,513	5,266	102,117	14,629	2,849	816,244	277,220	53,107	11,886	2,921	3,690	9,614	.260	.326	.380	.705
7	Dodgers	21,315	.531	11,234	9,942	726,272	95,896	189,793	30,381	6,951	13,573	86,183	67,476	4,984	97,261	17,068	3,493	814,488	274,795	50,905	12,756	2,924	3,664	9,711	.261	.327	.378	.706
8	Cardinals	20,282	.514	10,351	9,800	693,838	90,793	184,581	31,217	7,015	12,441	82,922	62,980	5,053	95,144	14,790	3,547	776,852	267,151	50,673	11,938	3,043	3,740	9,885	.266	.330	.385	.715
9	Tigers	19,012	.503	9,512	9,407	648,474	87,427	171,662	29,028	6,212	14,193	80,444	64,402	4,325	93,367	11,111	2,886	731,211	255,693	49,433	10,988	3,022	2,421	10,489	.265	.334	.394	.728
10	Twins	18,999	.481	9,090	9,800	648,232	83,458	170,227	29,105	6,280	11,555	76,781	61,158	4,939	91,124	11,837	3,029	727,572	246,557	46,940	10,167	3,076	2,632	10,708	.263	.329	.380	.710
11	Orioles	18,990	.473	8,928	9,952	645,032	81,823	166,546	28,692	4,844	13,961	75,582	62,154	4,345	95,204	10,310	2,723	725,031	246,809	47,497	10,503	2,997	2,544	10,621	.258	.326	.383	.709
12	Guardians	18,989	.512	9,684	9,214	647,469	85,963	171,676	30,544	5,447	13,558	79,417	61,537	4,675	91,890	11,576	3,294	728,356	253,788	49,549	11,426	3,249	2,469	10,281	.265	.332	.392	.724
13	White Sox	18,985	.503	9,492	9,390	642,972	82,763	167,341	27,652	5,527	11,945	76,022	61,170	5,142	88,841	13,411	3,420	724,767	241,882	45,124	12,329	3,154	2,433	10,254	.260	.328	.376	.704
14	Red Sox	18,977	.518	9,796	9,098	649,422	88,609	173,445	32,380	5,543	14,167	82,120	65,665	4,640	92,183	9,329	2,469	733,555	259,412	52,090	10,574	3,254	2,942	11,297	.267	.337	.399	.737
15	Athletics	18,951	.488	9,210	9,654	642,578	83,853	165,718	28,656	5,286	13,714	77,210	63,374	4,586	95,658	11,837	3,143	724,190	246,088	47,656	10,632	3,020	2,244	10,344	.258	.327	.383	.710
16	Yankees	18,690	.570	10,602	8,000	637,277	90,879	169,498	28,086	5,457	16,785	84,385	67,170	4,808	91,668	11,429	2,734	721,999	258,853	50,328	9,571	3,173	2,778	10,397	.266	.339	.406	.745
17	Angels	9,815	.498	4,885	4,927	333,193	42,510	85,501	14,747	1,764	8,753	39,984	31,201	2,639	59,342	5,820	3,012	373,226	130,035	25,264	3,514	2,679	2,447	7,615	.257	.323	.390	.713
18	Rangers	9,802	.475	4,650	5,146	334,690	44,046	86,455	15,359	1,854	9,738	41,594	31,678	2,575	62,094	5,727	2,792	374,630	134,736	26,951	2,945	2,742	2,211	7,570	.258	.325	.403	.727
19	Astros	9,656	.501	4,831	4,820	327,589	40,999	83,458	15,295	2,129	7,969	38,558	31,207	2,741	60,139	6,925	3,067	368,149	126,918	25,393	3,996	2,616	3,094	7,116	.255	.322	.387	.710
20	Mets	9,648	.483	4,652	4,988	326,536	39,641	81,680	14,550	1,770	8,104	37,293	31,197	2,633	61,877	5,627	2,692	366,851	124,082	24,424	3,957	2,528	3,109	7,208	.250	.318	.380	.698
21	Padres	8,522	.464	3,952	4,568	288,145	34,334	71,798	12,664	1,722	6,823	32,268	27,358	2,000	56,757	5,711	2,534	323,312	108,375	21,209	3,650	2,159	2,647	6,203	.249	.316	.376	.693
22	Brewers	8,518	.484	4,123	4,391	289,317	37,800	74,244	13,832	1,702	8,323	35,809	27,690	2,586	55,656	5,576	2,647	325,053	116,449	23,857	3,129	2,331	2,118	6,344	.257	.325	.402	.727
23	Nationals	8,514	.484	4,123	4,387	288,047	35,660	73,165	14,091	1,738	7,269	33,506	27,235	2,453	54,431	6,150	2,659	323,756	112,539	23,098	3,824	2,197	2,863	6,247	.254	.321	.391	.712
24	Royals	8,509	.478	4,066	4,441	291,318	37,262	76,713	14,309	2,202	6,639	35,129	25,037	2,320	49,231	6,753	2,802	323,538	115,343	23,150	2,322	2,541	1,826	6,566	.263	.324	.396	.720
25	Blue Jays	7,228	.498	3,598	3,627	247,803	33,522	64,585	12,878	1,445	7,872	31,793	22,930	2,260	46,089	4,373	1,904	276,499	103,969	22,195	1,473	2,033	1,361	5,638	.261	.326	.420	.746