most games played by one team against another team mlb

The Chicago Cubs and the Pittsburgh Pirates are tied for the most games against a team, with 2,621 games.

Interpreted as:

most regular-season games played by one team against another team MLB

	TEAM	G	OPP	W%	W	L	AB	R	H	2B	3B	HR	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	2,621	Pirates	.494	1,286	1,317		11,651								342			6,048		346	408	1,226		.324		.706
2	Pirates	2,621	Cubs	.506	1,317	1,286		11,481								413			5,963		358	445	1,155		.326		.707
3	Giants	2,593	Dodgers	.500	1,288	1,288		11,035								364			5,556		269	455	1,114		.319		.688
4	Dodgers	2,593	Giants	.500	1,288	1,288		11,146								398			5,576		354	462	1,052		.320		.692
5	Braves	2,557	Phillies	.523	1,330	1,212		11,784								293			5,980		279	347	1,024		.329		.719
6	Phillies	2,557	Braves	.477	1,212	1,330		10,971								291			5,520		287	384	1,095		.327		.704
7	Pirates	2,529	Cardinals	.511	1,279	1,226		11,440								302			5,949		365	399	1,316		.329		.712
8	Cardinals	2,529	Pirates	.489	1,226	1,279		11,085								406			5,932		361	451	1,306		.329		.711
9	Cubs	2,526	Cardinals	.511	1,281	1,226		11,045								315			5,969		323	388	1,262		.326		.707
10	Cardinals	2,526	Cubs	.489	1,226	1,281		11,026								419			5,997		357	405	1,167		.329		.713
11	Reds	2,506	Pirates	.496	1,234	1,253		11,062								302			5,632		334	393	1,093		.325		.709
12	Pirates	2,506	Reds	.504	1,253	1,234		10,920								307			5,632		310	299	1,055		.326		.708
13	Cubs	2,429	Reds	.504	1,213	1,194		10,977								278			5,913		288	339	1,009		.328		.718
14	Reds	2,429	Cubs	.496	1,194	1,213		10,551								330			5,635		297	346	953		.324		.702
15	Braves	2,400	Giants	.468	1,111	1,263		10,352								252			4,531		244	377	954		.316		.679
16	Giants	2,400	Braves	.532	1,263	1,111		11,205								279			5,123		253	357	1,044		.332		.721
17	Cubs	2,398	Phillies	.524	1,247	1,133		11,580								250			5,603		255	308	932		.332		.727
18	Phillies	2,398	Cubs	.476	1,133	1,247		10,912								311			5,264		262	359	878		.329		.713
19	Reds	2,389	Dodgers	.490	1,164	1,211		10,229								312			5,010		208	283	930		.318		.687
20	Dodgers	2,389	Reds	.510	1,211	1,164		10,559								318			5,036		268	346	1,027		.327		.704
21	Reds	2,386	Cardinals	.477	1,127	1,238		10,293								295			5,486		317	346	1,093		.324		.701
22	Cardinals	2,386	Reds	.523	1,238	1,127		10,708								332			5,839		307	357	1,049		.331		.720
23	Red Sox	2,339	Orioles	.548	1,275	1,050	80,323	11,220	21,815	4,029	687	1,683	8,220	538	1,241	287	90,863	32,267	6,399	1,523	325	276	1,294	.272	.342	.402	.744
24	Orioles	2,339	Red Sox	.452	1,050	1,275	79,689	10,129	20,710	3,804	611	1,513	7,514	514	1,315	275	89,414	30,275	5,928	1,433	339	231	1,240	.260	.326	.380	.706
25	Guardians	2,339	Tigers	.500	1,163	1,164	79,448	10,490	20,838	3,774	673	1,604	7,730	688	1,384	351	89,569	30,770	6,051	1,495	354	290	1,125	.262	.332	.387	.719