Jesse Orosco had the most games pitched when allowing exactly 0 hits, with 625 games.

Interpreted as:

most regular-season games by a player with 0 hits allowed

	NAME	G	H	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Jesse Orosco J. Orosco	625	0	37	7	.841	0	0.35	512	0	0	84	518.0	20	31	0	226	15	250	24	1,762	19	8.90	3.93	2.27	0.00	29.1	12.8	0.44	.000	0.54	0.00
2	Mike Stanton M. Stanton	521	0	33	2	.943	0	0.36	378	0	0	52	452.0	18	21	0	133	12	172	12	1,470	11	7.53	2.65	2.84	0.00	25.7	9.0	0.29	.000	0.42	0.00
3	Mariano Rivera M. Rivera	517	0	26	0	1.000	0	0.02	510	0	0	368	544.2	1	1	0	80	13	477	1	1,731	1	8.43	1.32	6.38	0.00	29.5	4.6	0.15	.000	0.02	0.00
4	Mike Myers M. Myers	515	0	16	6	.727	0	0.57	229	0	0	13	286.1	18	18	0	137	20	111	16	986	3	7.20	4.31	1.67	0.00	23.2	13.9	0.48	.000	0.57	0.00
5	Dan Plesac D. Plesac	515	0	34	2	.944	0	0.22	438	0	0	90	417.0	10	13	0	155	3	206	10	1,386	7	9.45	3.35	2.83	0.00	31.6	11.2	0.37	.000	0.28	0.00
6	Aroldis Chapman A. Chapman	510	0	36	1	.973	0	0.39	809	0	0	231	489.0	21	26	0	220	13	336	1	1,676	23	14.89	4.05	3.68	0.00	48.3	13.1	0.45	.000	0.48	0.00
7	Kenley Jansen K. Jansen	506	0	24	0	1.000	0	0.00	696	0	0	291	504.2	0	4	0	127	14	399	6	1,658	5	12.41	2.26	5.48	0.00	42.0	7.7	0.25	.000	0.07	0.00
8	Javier Lopez J. Lopez	502	0	17	3	.850	0	0.45	211	0	0	13	299.0	15	20	0	116	17	100	9	1,001	6	6.35	3.49	1.82	0.00	21.1	11.6	0.39	.000	0.60	0.00
9	Trevor Hoffman T. Hoffman	498	0	23	2	.920	0	0.05	544	0	0	355	506.1	3	4	0	104	1	441	7	1,621	12	9.67	1.85	5.23	0.00	33.6	6.4	0.21	.000	0.07	0.00
10	Craig Kimbrel C. Kimbrel	477	0	29	3	.906	0	0.19	749	0	0	295	468.1	10	12	0	154	23	388	3	1,580	28	14.39	2.96	4.86	0.00	47.4	9.7	0.33	.000	0.23	0.00
11	Francisco Rodriguez F. Rodriguez	465	0	21	0	1.000	0	0.02	568	0	0	246	463.0	1	1	0	163	10	355	7	1,545	21	11.04	3.17	3.48	0.00	36.8	10.6	0.35	.000	0.02	0.00
12	Billy Wagner B. Wagner	448	0	21	2	.913	0	0.08	629	0	0	251	463.1	4	5	0	131	14	384	4	1,528	11	12.22	2.54	4.80	0.00	41.2	8.6	0.28	.000	0.10	0.00
13	Fernando Rodney F. Rodney	446	0	25	5	.833	0	0.21	459	0	0	186	433.2	10	13	0	179	15	292	6	1,460	13	9.53	3.71	2.56	0.00	31.4	12.3	0.41	.000	0.27	0.00
14	John Franco J. Franco	444	0	37	3	.925	0	0.08	357	0	0	203	449.2	4	6	0	128	7	324	12	1,468	10	7.15	2.56	2.79	0.00	24.3	8.7	0.28	.000	0.12	0.00
15	David Robertson D. Robertson	440	0	40	0	1.000	1	0.00	603	0	0	106	452.1	0	1	0	155	9	183	9	1,503	19	12.00	3.08	3.89	0.00	40.1	10.3	0.34	.000	0.02	0.00
16	Alan Embree A. Embree	425	0	22	5	.815	0	0.36	320	0	0	17	348.2	14	23	0	115	9	115	14	1,159	5	8.26	2.97	2.78	0.00	27.6	9.9	0.33	.000	0.59	0.00
17	Sergio Romo S. Romo	424	0	28	0	1.000	3	0.14	418	0	0	75	375.1	6	6	0	76	15	160	4	1,204	7	10.02	1.82	5.50	0.00	34.7	6.3	0.20	.000	0.14	0.00
18	Joe Smith J. Smith	424	0	28	3	.903	0	0.23	320	0	0	19	359.2	9	11	0	92	27	88	9	1,183	6	8.01	2.30	3.48	0.00	27.0	7.8	0.26	.000	0.28	0.00
19	Eddie Guardado E. Guardado	418	0	22	4	.846	0	0.38	355	0	0	105	359.1	15	17	0	124	5	197	7	1,196	6	8.89	3.11	2.86	0.00	29.7	10.4	0.35	.000	0.43	0.00
20	Arthur Rhodes A. Rhodes	415	0	32	3	.914	0	0.24	404	0	0	22	379.1	10	10	0	123	4	80	13	1,252	9	9.59	2.92	3.28	0.00	32.3	9.8	0.32	.000	0.24	0.00
21	Michael Jackson M. Jackson	411	0	34	3	.919	0	0.14	385	0	0	76	440.1	7	12	0	132	16	204	12	1,451	8	7.87	2.70	2.92	0.00	26.5	9.1	0.30	.000	0.25	0.00
22	Randy Choate R. Choate	409	0	12	2	.857	0	0.48	210	0	0	6	227.0	12	16	0	82	24	59	10	772	4	8.33	3.25	2.56	0.00	27.2	10.6	0.36	.000	0.63	0.00
23	Roberto Hernandez R. Hernandez	409	0	21	1	.955	0	0.11	382	0	0	164	409.0	5	11	0	144	11	281	6	1,369	12	8.41	3.17	2.65	0.00	27.9	10.5	0.35	.000	0.24	0.00
24	Mike Timlin M. Timlin	407	0	30	0	1.000	0	0.15	322	0	0	78	426.0	7	8	0	91	13	208	3	1,357	5	6.80	1.92	3.54	0.00	23.7	6.7	0.21	.000	0.17	0.00
25	Joe Nathan J. Nathan	396	0	21	2	.913	0	0.16	486	0	0	230	385.0	7	8	0	97	7	320	5	1,252	8	11.36	2.27	5.01	0.00	38.8	7.7	0.25	.000	0.19	0.00