Babe Ruth had the most games with 2+ XBH, with 249 games.

Interpreted as:

most regular-season games by a player with 2 or more xbh

	NAME	G	XBH	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Babe Ruth B. Ruth	249	537	1,011	487	643	218	52	267	644	166	2	88	15		1,189	1,766	10				.636	.688	1.747	2.435
2	Barry Bonds B. Bonds	246	514	977	449	605	223	31	260	555	154	8	87	44	9	1,144	1,670	0	5	43	11	.619	.670	1.709	2.380
3	Stan Musial S. Musial	226	476	976	360	597	243	70	163	444	93	4	31	7	2	1,077	1,469	0	4	6	12	.612	.644	1.505	2.150
4	Albert Pujols A. Pujols	220	460	949	392	564	216	7	237	556	73	13	69	7	5	1,044	1,505	0	9	24	21	.594	.623	1.586	2.208
5	Willie Mays W. Mays	207	440	890	381	541	175	53	212	448	68	2	55	27	10	963	1,458	0	3	8	10	.608	.634	1.638	2.273
6	Lou Gehrig L. Gehrig	204	446	881	420	564	197	54	195	573	114	5	39	9		1,009	1,454	9				.640	.683	1.650	2.333
7	Hank Aaron H. Aaron	203	427	855	364	511	178	30	219	482	75	3	55	11	6	938	1,406	0	5	18	11	.598	.628	1.644	2.272
8	David Ortiz D. Ortiz	202	425	843	328	503	224	9	192	457	84	5	89	1	0	938	1,321	0	6	19	10	.597	.631	1.567	2.198
9	Miguel Cabrera M. Cabrera	187	398	792	319	499	213	3	182	456	72	3	79	1	2	873	1,264	0	6	19	15	.630	.658	1.596	2.253
10	Alex Rodriguez A. Rodriguez	187	400	805	362	495	176	12	212	491	73	11	96	19	7	897	1,331	1	7	4	16	.615	.646	1.653	2.300
11	Jimmie Foxx J. Foxx	184	396	764	359	479	155	42	199	493	116	0	60	12		885	1,315	5			4	.627	.676	1.721	2.397
12	Manny Ramirez M. Ramirez	182	389	733	348	458	178	9	202	459	87	7	91	2	5	832	1,260	0	5	13	14	.625	.663	1.719	2.382
13	Sammy Sosa S. Sosa	182	380	773	330	440	136	16	228	474	55	2	117	9	4	833	1,292	0	3	10	9	.569	.597	1.671	2.268
14	Ken Griffey Jr. K. Griffey Jr.	180	383	786	321	452	176	10	197	441	64	6	81	8	3	863	1,239	0	7	18	7	.575	.605	1.576	2.181
15	Frank Robinson F. Robinson	175	367	720	337	434	154	22	191	421	75	11	63	11	3	809	1,205	0	3	13	11	.603	.643	1.674	2.316
16	Ted Williams T. Williams	173	365	726	304	461	183	29	153	442	118	1	39	2	0	846	1,161	0	1	5	7	.635	.686	1.599	2.285
17	Rogers Hornsby R. Hornsby	173	364	731	294	482	194	55	115		75	5	40	13		825	1,131	14				.659	.693	1.547	2.240
18	Rafael Palmeiro R. Palmeiro	172	354	741	274	431	192	15	147	370	62	3	67	4	1	812	1,094	0	6	9	13	.582	.611	1.476	2.087
19	Jim Thome J. Thome	168	351	667	314	401	149	8	194	407	95	1	119	1	1	766	1,148	0	3	12	4	.601	.649	1.721	2.370
20	Tristram Speaker T. Speaker	166	345	705	261	442	250	61	34		75	1		20		796	916	15				.627	.663	1.299	1.963
21	Adrian Beltre A. Beltre	165	349	711	265	426	187	17	145	347	37	2	55	5	3	754	1,082	0	4	4	7	.599	.617	1.522	2.139
22	George Brett G. Brett	165	352	716	237	433	204	51	97	300	49	3	33	13	7	775	1,030	1	6	12	13	.605	.627	1.439	2.065
23	Chipper Jones C. Jones	164	341	689	300	412	163	14	164	350	83	0	57	14	4	776	1,095	1	3	10	12	.598	.639	1.589	2.228
24	Mike Schmidt M. Schmidt	159	334	651	275	388	135	27	172	394	80	5	71	10	7	738	1,093	1	1	13	8	.596	.642	1.679	2.321
25	Reggie Jackson R. Jackson	159	330	666	272	386	151	10	169	385	73	4	97	8	5	746	1,064	1	2	7	5	.580	.621	1.598	2.219