The San Francisco Giants have the most wins by a team when the run differential has been 4 or above runs, with 4,547 wins.

Interpreted as:

most games won in the regular season by 4 runs or more

	TEAM	W	DIFF	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Giants	4,547	28,316	0	1.000	4,550		39,308										582			14,857		904	1,044	1,765		.406		.931
2	Yankees	4,522	28,551	0	1.000	4,522	162,318	39,518	54,288	9,654	2,001	6,726		20,326	1,592		3,488	626	188,260	88,122	18,381	2,837	1,220	851	2,427	.334	.411	.543	.954
3	Dodgers	4,479	27,553	0	1.000	4,480		37,924										755			14,410		1,055	1,051	2,000		.403		.921
4	Cubs	4,468	27,977	0	1.000	4,470		39,127										495			13,891		854	885	1,592		.403		.924
5	Braves	4,240	26,733	0	1.000	4,242		37,003										563			13,075		946	983	1,806		.402		.929
6	Reds	4,114	25,477	0	1.000	4,115		35,367										614			13,318		935	1,025	1,615		.404		.928
7	Pirates	4,081	25,281	0	1.000	4,081		34,698										521			13,394		843	901	1,555		.404		.920
8	Cardinals	3,989	24,360	0	1.000	3,989		33,750										672			14,797		988	1,039	1,898		.407		.932
9	Red Sox	3,956	24,678	0	1.000	3,957	141,917	34,408	48,149	9,788	1,783	5,018		17,451	1,367		2,671	507	164,515	76,557	16,589	2,676	1,104	871	2,288	.339	.414	.539	.953
10	Guardians	3,775	23,494	0	1.000	3,775	135,419	32,360	46,128	8,874	1,785	4,502		15,375	1,258		3,262	589	155,981	72,078	15,161	2,999	1,039	653	1,997	.341	.410	.532	.942
11	Phillies	3,749	23,369	0	1.000	3,751		32,524										518			12,471		844	953	1,498		.403		.930
12	Tigers	3,720	23,055	0	1.000	3,720	133,042	32,042	45,283	8,133	1,942	4,535		15,823	1,133		3,233	569	153,734	70,905	14,610	2,916	962	717	1,915	.340	.412	.533	.945
13	White Sox	3,566	21,819	0	1.000	3,566	126,628	30,107	42,594	7,593	1,670	3,821		14,579	1,335		3,669	679	146,686	64,990	13,084	3,114	1,030	658	1,812	.336	.408	.513	.921
14	Athletics	3,503	21,522	0	1.000	3,503	124,303	29,668	41,404	7,753	1,507	4,263		14,997	1,169		3,125	593	144,141	64,960	13,523	2,771	990	562	1,697	.333	.407	.523	.930
15	Twins	3,496	21,347	0	1.000	3,496	125,722	29,725	42,496	7,792	1,818	3,801		14,107	1,326		3,140	633	144,464	65,327	13,411	2,441	990	715	1,746	.338	.408	.520	.927
16	Orioles	3,349	20,054	0	1.000	3,349	119,084	27,803	39,587	7,449	1,319	4,311		13,676	1,088		2,705	531	136,767	62,607	13,079	2,409	951	680	1,793	.332	.403	.526	.929
17	Astros	1,859	11,345	0	1.000	1,859	66,392	15,445	21,906	4,401	647	2,750	14,582	7,693	829	11,087	1,579	527	76,552	35,851	7,798	832	806	795	1,351	.330	.402	.540	.942
18	Rangers	1,848	11,325	0	1.000	1,848	66,623	15,899	22,304	4,375	563	3,146	15,049	7,541	702	10,951	1,397	519	76,337	37,243	8,084	616	855	573	1,324	.335	.403	.559	.962
19	Angels	1,839	11,084	0	1.000	1,839	65,985	15,301	21,899	4,104	532	2,787	14,432	7,313	689	10,405	1,452	540	75,537	35,428	7,423	720	830	607	1,353	.332	.400	.537	.937
20	Mets	1,742	10,386	0	1.000	1,742	61,976	14,041	20,085	3,980	517	2,599	13,287	7,008	695	10,554	1,402	426	71,222	32,896	7,096	807	736	767	1,200	.324	.395	.531	.925
21	Brewers	1,638	9,962	0	1.000	1,638	58,339	13,626	19,059	3,732	522	2,632	12,927	6,708	689	9,980	1,409	465	67,093	31,731	6,886	634	723	578	1,132	.327	.398	.544	.942
22	Royals	1,591	9,597	0	1.000	1,591	57,481	13,321	19,465	3,863	663	2,086	12,570	5,937	588	8,401	1,686	496	65,220	30,912	6,612	438	776	506	1,152	.339	.401	.538	.939
23	Blue Jays	1,544	9,445	0	1.000	1,544	55,519	12,992	18,364	3,890	455	2,772	12,353	6,040	660	9,096	1,128	367	63,195	31,480	7,117	284	692	367	1,152	.331	.398	.567	.965
24	Nationals	1,510	8,915	0	1.000	1,510	53,634	12,229	17,397	3,687	462	2,242	11,488	5,888	579	9,339	1,430	434	61,525	28,734	6,391	803	621	713	981	.324	.393	.536	.929
25	Padres	1,403	8,300	0	1.000	1,403	50,092	11,496	16,446	3,191	453	2,025	10,845	5,808	490	8,702	1,189	363	57,693	26,618	5,669	672	631	618	985	.328	.399	.531	.930