Babe Ruth has launched the most career homers in the AL with >0 games played, with 708 homers.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Babe Ruth B. Ruth	708	2,476	8,328	2,160	2,860	506	136	2,201	2,042	44	1,307	123		10,530	5,762	1,350	116				.343	.475	.692	1.167
2	Alex Rodriguez A. Rodriguez	696	2,784	10,566	2,021	3,115	548	31	2,086	1,338	176	2,287	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930
3	Harmon Killebrew H. Killebrew	573	2,435	8,147	1,282	2,086	290	24	1,583	1,561	48	1,704	19	20	9,833	4,143	887	0	77	161	243	.256	.376	.509	.884
4	Reggie Jackson R. Jackson	563	2,820	9,864	1,551	2,584	463	49	1,702	1,376	96	2,596	228	115	11,417	4,834	1,075	13	68	164	183	.262	.356	.490	.846
5	Rafael Palmeiro R. Palmeiro	544	2,573	9,598	1,547	2,763	525	32	1,739	1,291	82	1,282	82	35	11,095	4,984	1,101	13	111	165	213	.288	.373	.519	.892
6	David Ortiz D. Ortiz	541	2,408	8,640	1,419	2,472	632	19	1,768	1,319	38	1,750	17	9	10,091	4,765	1,192	2	92	209	236	.286	.380	.552	.931
7	Mickey Mantle M. Mantle	536	2,401	8,101	1,675	2,415	344	72	1,509	1,733	12	1,718	152	42	9,907	4,511	952	14	47	126	113	.298	.420	.557	.977
8	Jimmie Foxx J. Foxx	524	2,143	7,685	1,696	2,542	438	124	1,865	1,409	13	1,212	86		9,178	4,800	1,086	71			57	.331	.435	.625	1.060
9	Frank Thomas F. Thomas	521	2,322	8,199	1,494	2,468	495	12	1,704	1,667	87	1,397	32	23	10,074	4,550	1,028	0	121	168	226	.301	.419	.555	.974
10	Ted Williams T. Williams	521	2,292	7,706	1,799	2,654	525	71	1,839	2,018	39	709	24	5	9,788	4,884	1,117	5	20	89	201	.344	.482	.634	1.115
11	Manny Ramirez M. Ramirez	511	2,079	7,509	1,414	2,337	494	18	1,675	1,191	98	1,656	35	31	8,882	4,400	1,023	2	82	175	227	.311	.408	.586	.994
12	Jim Thome J. Thome	511	2,135	7,064	1,340	1,976	384	22	1,415	1,479	60	2,135	19	15	8,667	3,937	917	1	63	131	143	.280	.406	.557	.963
13	Lou Gehrig L. Gehrig	493	2,164	8,001	1,888	2,721	534	163	1,998	1,511	46	789	102		9,664	5,060	1,190	106			2	.340	.448	.632	1.080
14	Jose Canseco J. Canseco	462	1,887	7,057	1,186	1,877	340	14	1,407	906	84	1,942	200	88	8,129	3,631	816	1	81	64	178	.266	.353	.515	.867
15	Carl Yastrzemski C. Yastrzemski	452	3,308	11,988	1,816	3,419	646	59	1,844	1,845	40	1,395	168	115	13,991	5,539	1,157	13	105	190	325	.285	.379	.462	.841
16	Nelson Cruz N. Cruz	449	1,874	6,905	1,030	1,912	350	14	1,238	681	80	1,751	79	32	7,724	3,637	813	2	56	76	161	.277	.346	.527	.873
17	Juan Gonzalez J. Gonzalez	434	1,689	6,556	1,061	1,936	388	25	1,404	457	62	1,273	26	19	7,155	3,676	847	2	78	74	184	.295	.343	.561	.904
18	Paul Konerko P. Konerko	432	2,268	8,169	1,141	2,292	406	8	1,383	904	101	1,349	9	3	9,258	4,010	846	1	83	80	271	.281	.356	.491	.847
19	Cal Ripken Jr. C. Ripken Jr.	431	3,001	11,551	1,647	3,184	603	44	1,695	1,129	66	1,305	36	39	12,883	5,168	1,078	10	127	107	350	.276	.340	.447	.788
20	Ken Griffey Jr. K. Griffey Jr.	420	1,726	6,448	1,129	1,877	351	30	1,234	836	49	1,106	167	60	7,400	3,548	801	6	61	173	124	.291	.374	.550	.924
21	Jason Giambi J. Giambi	418	2,030	6,847	1,179	1,906	385	9	1,355	1,287	169	1,448	18	12	8,390	3,563	812	2	85	90	156	.278	.401	.520	.921
22	Al Kaline A. Kaline	399	2,834	10,116	1,622	3,007	498	75	1,582	1,276	55	1,020	137	68	11,596	4,852	972	45	104	133	276	.297	.376	.480	.855
23	Eddie Murray E. Murray	396	2,239	8,440	1,255	2,454	421	27	1,442	1,001	15	1,156	79	29	9,550	4,117	844	2	92	148	227	.291	.363	.488	.851
24	Mike Trout M. Trout	387	1,547	5,616	1,137	1,667	312	55	972	992	101	1,520	214	38	6,766	3,250	754	0	57	122	69	.297	.408	.579	.987
25	Dwight Evans D. Evans	385	2,606	8,996	1,470	2,446	483	73	1,384	1,391	53	1,697	78	59	10,569	4,230	941	52	77	60	227	.272	.370	.470	.840