Between the 2000 and 2021 seasons, Albert Pujols crushed the most homers, with 679 home runs.

	NAME	HR	G	AB	R	H	2B	3B	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Albert Pujols A. Pujols	679	2,971	11,114	1,872	3,301	672	16	2,150	1,345	113	1,349	116	41	12,690	6,042	1,367	1	117	315	413	.297	.375	.544	.919	2174	665.5	.385	141	652.9
2	Alex Rodriguez A. Rodriguez	548	2,142	7,994	1,528	2,324	388	20	1,623	1,128	152	1,792	211	44	9,364	4,396	956	0	90	93	208	.291	.385	.550	.935	1684	554.7	.397	143	508.3
3	David Ortiz D. Ortiz	531	2,297	8,293	1,361	2,379	609	19	1,716	1,273	33	1,647	16	9	9,689	4,619	1,159	2	88	206	225	.287	.380	.557	.937	1706	556	.394	141	483.8
4	Miguel Cabrera M. Cabrera	502	2,587	9,625	1,505	2,987	597	17	1,804	1,199	69	1,930	39	21	10,993	5,124	1,116	5	95	235	342	.310	.387	.532	.920	1904	603.1	.389	143	563.6
5	Adam Dunn A. Dunn	462	2,001	6,883	1,097	1,631	334	10	1,168	1,317	86	2,379	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
6	Adrian Beltre A. Beltre	455	2,704	10,335	1,422	2,976	600	33	1,618	773	88	1,590	100	34	11,302	5,007	1,088	8	98	100	271	.288	.340	.484	.824	1608	265.5	.352	117	222.6
7	Nelson Cruz N. Cruz	449	1,882	6,910	1,031	1,913	351	14	1,238	683	80	1,751	79	32	7,731	3,639	814	2	56	76	161	.277	.346	.527	.873	1229	324.4	.369	132	297.5
8	Edwin Encarnacion E. Encarnacion	424	1,960	7,040	1,099	1,832	370	10	1,261	903	105	1,426	61	14	8,114	3,494	804	0	66	54	185	.260	.350	.496	.846	1233	280.2	.362	125	235.4
9	Jim Thome J. Thome	416	1,627	5,345	974	1,445	270	10	1,120	1,101	40	1,666	3	9	6,531	2,983	696	0	45	123	101	.270	.396	.558	.954	1201	402.9	.402	145	365.9
10	Carlos Beltran C. Beltran	413	2,416	9,047	1,458	2,515	533	68	1,472	1,035	46	1,660	282	41	10,245	4,423	1,014	18	99	102	184	.278	.352	.489	.841	1518	296.4	.359	120	251.8
11	Alfonso Soriano A. Soriano	411	1,966	7,742	1,150	2,094	481	31	1,158	496	86	1,800	289	83	8,387	3,870	923	9	54	68	123	.270	.319	.500	.819	1163	162.4	.348	111	113.3
12	Mark Teixeira M. Teixeira	409	1,862	6,936	1,099	1,862	408	18	1,298	918	111	1,441	26	7	8,029	3,533	835	0	64	91	158	.268	.360	.509	.869	1268	317.6	.371	127	262.4
13	Paul Konerko P. Konerko	408	2,126	7,656	1,070	2,141	375	4	1,302	859	99	1,281	8	3	8,694	3,748	787	0	80	80	252	.280	.356	.490	.846	1314	271.1	.363	120	213.3
14	Ryan Howard R. Howard	382	1,572	5,707	848	1,475	277	21	1,194	709	59	1,843	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
15	Aramis Ramirez A. Ramirez	380	2,104	7,829	1,073	2,234	484	22	1,386	609	123	1,157	29	17	8,647	3,902	886	1	85	58	230	.285	.343	.498	.841	1283	254.5	.360	117	186.8
16	Lance Berkman L. Berkman	362	1,845	6,398	1,136	1,883	420	30	1,219	1,189	66	1,279	81	47	7,707	3,449	812	1	53	160	145	.294	.407	.539	.946	1412	479.8	.402	144	434.4
17	Vladimir Guerrero V. Guerrero	357	1,729	6,570	1,072	2,092	381	32	1,215	621	82	786	153	74	7,327	3,608	770	0	54	221	232	.318	.381	.549	.931	1271	379.2	.389	136	340.4
18	Manny Ramirez M. Ramirez	357	1,453	5,213	971	1,642	344	11	1,149	874	75	1,150	11	10	6,211	3,079	712	0	49	178	154	.315	.417	.591	1.008	1241	479.2	.421	157	445.5
19	Andruw Jones A. Jones	354	1,691	5,920	947	1,497	290	21	1,032	712	80	1,380	78	32	6,774	2,891	665	0	62	48	158	.253	.338	.488	.826	970	140.2	.353	112	105.8
20	Ryan Braun R. Braun	352	1,766	6,622	1,080	1,963	408	49	1,154	586	77	1,363	216	60	7,329	3,525	809	0	44	56	179	.296	.358	.532	.891	1210	352.7	.379	135	310.8
21	Giancarlo Stanton G. Stanton	347	1,324	4,839	762	1,299	265	11	893	647	49	1,559	42	15	5,568	2,627	623	0	33	81	117	.268	.358	.543	.901	932	289	.380	142	279.1
22	Jose Bautista J. Bautista	344	1,798	6,051	1,022	1,496	312	17	975	1,032	80	1,394	70	32	7,244	2,874	673	23	58	58	170	.247	.361	.475	.836	1085	241.2	.362	126	211.3
23	Curtis Granderson C. Granderson	344	2,057	7,236	1,217	1,800	346	95	937	924	67	1,916	153	50	8,306	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
24	Torii Hunter T. Hunter	344	2,230	8,456	1,244	2,350	480	37	1,354	633	91	1,663	185	92	9,251	3,936	861	5	66	51	252	.278	.332	.465	.798	1248	151.3	.344	112	129.1
25	Carlos Lee C. Lee	342	1,972	7,491	1,059	2,129	437	17	1,279	642	43	912	121	45	8,269	3,626	796	2	91	60	195	.284	.340	.484	.824	1178	177.1	.352	113	139.4