most home runs by a player in the second inning from 1908 to 2019

Between the 1908 and 2019 seasons, Adrian Beltre and Fred McGriff were tied for the most home runs in the 2nd inning, with 72 home runs.

	NAME	HR	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Adrian Beltre A. Beltre	72	1,484	1,372	420	94	5	146	102	7	195	1,491	740	171	0	10	1	.306	.355	.539	.894
2	Fred McGriff F. McGriff	72	1,080	965	287	50	2	112	112	5	179	1,084	557	124	0	2	1	.297	.373	.577	.950
3	Jim Thome J. Thome	69	1,126	965	279	57	7	155	155	3	248	1,128	557	133	0	5	4	.289	.387	.577	.965
4	Carlos Delgado C. Delgado	63	797	684	215	46	0	102	88	24	159	799	450	109	0	3	2	.314	.409	.658	1.067
5	Vinny Castilla V. Castilla	61	1,217	1,137	279	46	6	133	64	10	172	1,220	520	113	1	8	1	.245	.290	.457	.747
6	Barry Bonds B. Bonds	61	890	729	205	47	5	128	151	9	105	892	445	113	1	2	18	.281	.410	.610	1.020
7	Greg Vaughn G. Vaughn	57	758	668	177	29	4	95	88	4	156	760	385	90	0	0	0	.265	.354	.576	.930
8	Adam Dunn A. Dunn	56	840	711	188	43	1	87	120	9	217	841	401	100	0	1	2	.264	.377	.564	.941
9	Mark McGwire M. McGwire	56	732	629	156	35	0	87	97	5	132	733	359	91	0	2	1	.248	.352	.571	.923
10	Paul Konerko P. Konerko	55	1,204	1,119	322	61	2	98	83	10	142	1,214	552	118	0	2	1	.288	.342	.493	.835
11	Chris Davis C. Davis	52	806	711	174	33	0	85	81	12	266	807	363	85	1	2	0	.245	.331	.511	.842
12	Andruw Jones A. Jones	51	1,057	942	230	49	3	118	98	15	239	1,058	438	103	0	3	5	.244	.324	.465	.789
13	Jim Edmonds J. Edmonds	51	722	621	198	48	4	99	97	5	142	726	407	103	0	3	5	.319	.413	.655	1.069
14	Gary Carter G. Carter	50	1,274	1,150	283	42	5	103	109	8	145	1,276	485	97	3	6	3	.246	.314	.422	.736
15	Ron Cey R. Cey	50	1,179	1,043	278	53	0	94	127	11	202	1,183	481	103	0	2	1	.267	.352	.461	.813
16	Jason Giambi J. Giambi	49	753	652	174	35	2	119	89	15	138	757	360	86	0	1	3	.267	.367	.552	.919
17	Ryan Howard R. Howard	48	660	608	153	30	1	74	49	3	193	661	329	79	0	1	0	.252	.310	.541	.851
18	Benito Santiago B. Santiago	48	1,290	1,217	326	69	8	107	60	3	217	1,291	555	125	1	10	3	.268	.302	.456	.758
19	Graig Nettles G. Nettles	48	1,147	1,019	252	41	1	119	118	5	133	1,151	439	90	0	9	0	.247	.326	.431	.757
20	Sammy Sosa S. Sosa	47	769	690	186	33	5	97	71	3	179	770	370	85	1	5	3	.270	.338	.536	.874
21	Andres Galarraga A. Galarraga	47	1,033	950	288	55	2	104	65	18	205	1,036	488	104	0	3	3	.303	.358	.514	.872
22	Jorge Posada J. Posada	46	1,162	1,028	273	52	1	109	130	11	264	1,170	465	99	0	1	2	.266	.354	.452	.806
23	Jermaine Dye J. Dye	46	908	834	236	52	3	85	71	6	158	914	432	101	0	3	0	.283	.342	.518	.860
24	Mike Cameron M. Cameron	46	991	878	228	50	7	136	91	14	217	992	430	103	0	9	1	.260	.336	.490	.825
25	Alex Rodriguez A. Rodriguez	46	737	635	169	29	0	127	97	7	122	743	336	75	0	4	3	.266	.367	.529	.897