Between the 1908 and 2019 seasons, Adrian Beltre and Fred McGriff were tied for the most homers in the 2nd inning, with 72 home runs.

most home runs by a player in the second inning from 1908 to 2019

NAME	HR	G	PA	AB	H	2B	3B	RBI	BB	IBB	HBP	SO	SH	SF	TB	XBH	AVG	OBP	SLG	OPS
Adrian Beltre	72	1,484	1,491	1,372	420	94	5	146	102	1	7	195	0	10	740	171	.306	.355	.539	.894
Fred McGriff	72	1,080	1,084	965	287	50	2	112	112	1	5	179	0	2	557	124	.297	.373	.577	.950
Jim Thome	69	1,126	1,128	965	279	57	7	155	155	4	3	248	0	5	557	133	.289	.387	.577	.965
Carlos Delgado	63	797	799	684	215	46	0	102	88	2	24	159	0	3	450	109	.314	.409	.658	1.067
Vinny Castilla	61	1,217	1,220	1,137	279	46	6	133	64	1	10	172	1	8	520	113	.245	.290	.457	.747
Barry Bonds	61	890	892	729	205	47	5	128	151	18	9	105	1	2	445	113	.281	.410	.610	1.020
Greg Vaughn	57	758	760	668	177	29	4	95	88	0	4	156	0	0	385	90	.265	.354	.576	.930
Adam Dunn	56	840	841	711	188	43	1	87	120	2	9	217	0	1	401	100	.264	.377	.564	.941
Mark McGwire	56	732	733	629	156	35	0	87	97	1	5	132	0	2	359	91	.248	.352	.571	.923
Paul Konerko	55	1,204	1,214	1,119	322	61	2	98	83	1	10	142	0	2	552	118	.288	.342	.493	.835
Chris Davis	52	806	807	711	174	33	0	85	81	0	12	266	1	2	363	85	.245	.331	.511	.842
Andruw Jones	51	1,057	1,058	942	230	49	3	118	98	5	15	239	0	3	438	103	.244	.324	.465	.789
Jim Edmonds	51	722	726	621	198	48	4	99	97	5	5	142	0	3	407	103	.319	.413	.655	1.069
Gary Carter	50	1,274	1,276	1,150	283	42	5	103	109	3	8	145	3	6	485	97	.246	.314	.422	.736
Ron Cey	50	1,179	1,183	1,043	278	53	0	94	127	1	11	202	0	2	481	103	.267	.352	.461	.813
Jason Giambi	49	753	757	652	174	35	2	119	89	3	15	138	0	1	360	86	.267	.367	.552	.919
Ryan Howard	48	660	661	608	153	30	1	74	49	0	3	193	0	1	329	79	.252	.310	.541	.851
Benito Santiago	48	1,290	1,291	1,217	326	69	8	107	60	3	3	217	1	10	555	125	.268	.302	.456	.758
Graig Nettles	48	1,147	1,151	1,019	252	41	1	119	118	0	5	133	0	9	439	90	.247	.326	.431	.757
Sammy Sosa	47	769	770	690	186	33	5	97	71	3	3	179	1	5	370	85	.270	.338	.536	.874
Andres Galarraga	47	1,033	1,036	950	288	55	2	104	65	3	18	205	0	3	488	104	.303	.358	.514	.872
Jorge Posada	46	1,162	1,170	1,028	273	52	1	109	130	2	11	264	0	1	465	99	.266	.354	.452	.806
Jermaine Dye	46	908	914	834	236	52	3	85	71	0	6	158	0	3	432	101	.283	.342	.518	.860
Mike Cameron	46	991	992	878	228	50	7	136	91	1	14	217	0	9	430	103	.260	.336	.490	.825
Alex Rodriguez	46	737	743	635	169	29	0	127	97	3	7	122	0	4	336	75	.266	.367	.529	.897

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StatMuse has event-level data for home runs going back to the 1974 season.

Some of the information used here was obtained free of charge from Retrosheet.

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	NL East	W	L	PCT	GB
1	Braves	104	58	.642
2	Phillies	90	72	.556	14.0
	AL East	W	L	PCT	GB
1	Orioles	101	61	.623
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