Since 2000, the San Diego Padres and the Colorado Rockies are tied for pitching the most innings in a game, with 22 innings on April 17, 2008.

Interpreted as:

most ip by a team in a regular-season game since 2000

	TEAM	IP	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	H	ER	R	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Padres	22.0	4/17/2008	SDP	vs	COL	L 1-2	0.41	20	0	0	14	1	2	0	8	0	1	84	0	8.18	3.27	2.50	0.00	23.8	9.5	1.00	.250	0.82	5.73
2	Rockies	22.0	4/17/2008	COL	@	SDP	W 2-1	0.41	17	0	0	11	1	1	0	5	1	1	81	0	6.95	2.05	3.40	0.00	21.0	6.2	0.73	.190	0.41	4.50
3	Mets	20.0	6/8/2013	NYM	vs	MIA	L 1-2	0.90	16	0	0	15	2	2	0	2	0	0	72	0	7.20	0.90	8.00	0.00	22.2	2.8	0.85	.278	0.90	6.75
4	Marlins	20.0	6/8/2013	MIA	@	NYM	W 2-1	0.45	19	0	1	13	1	1	0	9	2	1	83	0	8.55	4.05	2.11	0.00	22.9	10.8	1.10	.245	0.45	5.85
5	Cardinals	20.0	4/17/2010	STL	vs	NYM	L 1-2	0.90	16	0	0	9	2	2	0	8	1	2	75	0	7.20	3.60	2.00	0.00	21.3	10.7	0.85	.180	0.90	4.05
6	Mets	20.0	4/17/2010	NYM	@	STL	W 2-1	0.45	19	0	1	15	1	1	0	11	0	2	83	0	8.55	4.95	1.73	0.00	22.9	13.3	1.30	.283	0.45	6.75
7	Cardinals	20.0	4/27/2003	STL	@	FLA	W 7-6	2.70	15	0	0	13	6	6	3	16	2	4	87	2	6.75	7.20	0.94	1.35	17.2	18.4	1.45	.196	2.70	5.85
8	Marlins	20.0	4/27/2003	FLA	vs	STL	L 6-7	2.70	8	0	0	22	6	7	0	5	0	1	83	0	3.60	2.25	1.60	0.00	9.6	6.0	1.35	.314	3.15	9.90
9	Diamondbacks	19.0	9/24/2019	ARI	vs	STL	W 3-2	0.95	25	0	0	13	2	2	2	4	0	0	73	0	11.84	1.89	6.25	0.95	34.2	5.5	0.89	.262	0.95	6.16
10	Red Sox	19.0	9/5/2017	BOS	vs	TOR	W 3-2	0.95	23	0	0	12	2	2	1	4	0	0	71	0	10.89	1.89	5.75	0.47	32.4	5.6	0.84	.256	0.95	5.68
11	Indians	19.0	7/1/2016	CLE	@	TOR	W 2-1	0.47	18	0	0	11	1	1	1	8	1	1	75	1	8.53	3.79	2.25	0.47	24.0	10.7	1.00	.213	0.47	5.21
12	Blue Jays	19.0	7/1/2016	TOR	vs	CLE	L 1-2	0.95	15	0	0	15	2	2	1	3	1	1	76	0	7.11	1.42	5.00	0.47	19.7	3.9	0.95	.250	0.95	7.11
13	Red Sox	19.0	4/10/2015	BOS	@	NYY	W 6-5	2.37	13	0	0	14	5	5	2	6	1	1	75	0	6.16	2.84	2.17	0.95	17.3	8.0	1.05	.226	2.37	6.63
14	Yankees	19.0	4/10/2015	NYY	vs	BOS	L 5-6	2.37	15	0	0	18	5	6	1	8	2	0	83	2	7.11	3.79	1.88	0.47	18.1	9.6	1.37	.298	2.84	8.53
15	Blue Jays	19.0	8/10/2014	TOR	vs	DET	W 6-5	0.95	17	0	0	22	2	5	0	5	0	2	81	0	8.05	2.37	3.40	0.00	21.0	6.2	1.42	.373	2.37	10.42
16	Angels	19.0	8/9/2014	LAA	vs	BOS	W 5-4	0.95	18	0	0	6	2	4	0	4	0	0	66	1	8.53	1.89	4.50	0.00	27.3	6.1	0.53	.136	1.89	2.84
17	Athletics	19.0	4/29/2013	OAK	vs	LAA	W 10-8	3.79	18	0	0	15	8	8	3	6	1	2	79	0	8.53	2.84	3.00	1.42	22.8	7.6	1.11	.235	3.79	7.11
18	Pirates	19.0	8/19/2012	PIT	@	STL	W 6-3	1.42	15	0	0	11	3	3	0	4	0	0	73	1	7.11	1.89	3.75	0.00	20.5	5.5	0.79	.204	1.42	5.21
19	Cardinals	19.0	8/19/2012	STL	vs	PIT	L 3-6	1.89	19	0	0	16	4	6	1	6	1	2	76	1	9.00	2.84	3.17	0.47	25.0	7.9	1.16	.306	2.84	7.58
20	Braves	19.0	7/26/2011	ATL	vs	PIT	W 4-3	1.42	20	0	0	13	3	3	1	7	0	3	76	0	9.47	3.32	2.86	0.47	26.3	9.2	1.05	.250	1.42	6.16
21	Phillies	19.0	5/25/2011	PHI	vs	CIN	W 5-4	1.89	16	0	0	15	4	4	1	5	2	1	78	0	7.58	2.37	3.20	0.47	20.5	6.4	1.05	.259	1.89	7.11
22	White Sox	19.0	7/9/2006	CWS	vs	BOS	W 6-5	2.37	18	0	0	11	5	5	1	11	2	2	79	3	8.53	5.21	1.64	0.47	22.8	13.9	1.16	.213	2.37	5.21
23	Mariners	19.0	8/1/2000	SEA	vs	BOS	W 5-4	1.89	5	0	0	12	4	4	1	9	0	1	75	0	2.37	4.26	0.56	0.47	6.7	12.0	1.11	.183	1.89	5.68
24	Cardinals	18.2	9/24/2019	STL	@	ARI	L 2-3	1.45	23	0	0	13	3	3	1	9	0	3	74	1	11.09	4.34	2.56	0.48	31.1	12.2	1.18	.293	1.45	6.27
25	Angels	18.2	4/29/2013	LAA	@	OAK	L 8-10	3.86	17	0	0	15	8	10	2	6	0	0	77	0	8.20	2.89	2.83	0.96	22.1	7.8	1.13	.250	4.82	7.23