6 players are tied for the most strikeouts in a game this season, with 5 strikeouts. The first three are Austin Slater on June 12, Tyler Stephenson on May 6 and Nick Castellanos on April 10.

Interpreted as:

most ks by a player in one MLB regular-season game this season

	NAME	SO	DATE	TM		OPP	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP
1	Austin Slater A. Slater	5	6/12/2025	CWS	@	HOU	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
2	Tyler Stephenson T. Stephenson	5	5/6/2025	CIN	@	ATL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
3	Nick Castellanos N. Castellanos	5	4/10/2025	PHI	@	ATL	5	1	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
4	Jose Altuve J. Altuve	5	4/3/2025	HOU	@	MIN	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
5	Dylan Crews D. Crews	5	3/29/2025	WSH	vs	PHI	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
6	Jackson Chourio J. Chourio	5	3/27/2025	MIL	@	NYY	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
7	Austin Hays A. Hays	4	7/11/2025	CIN	vs	COL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	1
8	Max Muncy M. Muncy	4	7/10/2025	ATH	vs	ATL	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
9	Cooper Hummel C. Hummel	4	7/9/2025	HOU	vs	CLE	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
10	Corbin Carroll C. Carroll	4	7/9/2025	AZ	@	SDP	5	1	1	0	0	1	1	0	0	0	0	5	4	1	0	0	0	0
11	Zack Short Z. Short	4	7/8/2025	HOU	vs	CLE	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
12	Corbin Carroll C. Carroll	4	7/6/2025	AZ	vs	KCR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
13	Randy Arozarena R. Arozarena	4	7/5/2025	SEA	vs	PIT	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
14	Bryce Harper B. Harper	4	7/5/2025	PHI	vs	CIN	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
15	Patrick Bailey P. Bailey	4	7/4/2025	SFG	@	ATH	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
16	Julio Rodríguez J. Rodríguez	4	7/3/2025	SEA	vs	KCR	4	0	0	0	0	0	0	1	0	1	0	5	0	0	0	0	0	0
17	Nick Kurtz N. Kurtz	4	7/2/2025	ATH	@	TBR	4	0	0	0	0	0	0	1	0	0	0	5	0	0	0	0	0	0
18	Eugenio Suárez E. Suárez	4	7/2/2025	AZ	vs	SFG	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
19	Cal Raleigh C. Raleigh	4	7/1/2025	SEA	vs	KCR	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
20	Ronald Acuña Jr. R. Acuña Jr.	4	7/1/2025	ATL	vs	LAA	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
21	Rafael Devers R. Devers	4	6/30/2025	SFG	@	AZ	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
22	Marcell Ozuna M. Ozuna	4	6/29/2025	ATL	vs	PHI	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
23	Adolis García A. García	4	6/28/2025	TEX	vs	SEA	4	0	0	0	0	0	0	0	0	0	0	4	0	0	0	0	0	0
24	Joey Bart J. Bart	4	6/23/2025	PIT	@	MIL	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0
25	Willson Contreras W. Contreras	4	6/21/2025	STL	vs	CIN	5	0	0	0	0	0	0	0	0	0	0	5	0	0	0	0	0	0