Shohei Ohtani has smashed the most homers when leading off a game this season, with 5 home runs.

Interpreted as:

most leadoff home runs for a player this regular season

	NAME	HR	SEASON	TM	G	AB	H	2B	3B	RBI	BB	HBP	SO	PA	TB	XBH	SH	SF	IBB	AVG	OBP	SLG	OPS
1	Shohei Ohtani S. Ohtani	5	2025	LAD	53	48	16	2	0	5	5	0	15	53	33	7	0	0	0	.333	.396	.688	1.084
2	Zach Neto Z. Neto	4	2025	LAA	26	25	8	0	0	4	1	0	9	26	20	4	0	0	0	.320	.346	.800	1.146
3	Oneil Cruz O. Cruz	4	2025	PIT	32	27	9	2	0	4	5	0	8	32	23	6	0	0	0	.333	.438	.852	1.289
4	Corbin Carroll C. Carroll	4	2025	AZ	38	33	10	0	2	4	4	1	7	38	26	6	0	0	0	.303	.395	.788	1.183
5	Francisco Lindor F. Lindor	4	2025	NYM	54	52	18	5	0	4	2	0	11	54	35	9	0	0	0	.346	.370	.673	1.043
6	Fernando Tatis Jr. F. Tatis Jr.	4	2025	SDP	52	47	12	2	0	4	5	0	15	52	26	6	0	0	0	.255	.327	.553	.880
7	CJ Abrams	4	2025	WSH	41	39	10	2	0	4	2	0	10	41	24	6	0	0	0	.256	.293	.615	.908
8	Trent Grisham T. Grisham	3	2025	NYY	17	14	3	0	0	3	3	0	4	17	12	3	0	0	0	.214	.353	.857	1.210
9	Kerry Carpenter K. Carpenter	3	2025	DET	27	26	8	1	0	3	1	0	3	27	18	4	0	0	0	.308	.333	.692	1.026
10	J.P. Crawford	2	2025	SEA	22	20	7	1	0	2	2	0	6	22	14	3	0	0	0	.350	.409	.700	1.109
11	Dylan Moore D. Moore	2	2025	SEA	6	6	3	0	0	2	0	0	0	6	9	2	0	0	0	.500	.500	1.500	2.000
12	James Wood J. Wood	2	2025	WSH	7	5	3	1	0	2	2	0	0	7	10	3	0	0	0	.600	.714	2.000	2.714
13	Cedric Mullins C. Mullins	2	2025	BAL	18	17	5	0	0	2	1	0	4	18	11	2	0	0	0	.294	.333	.647	.980
14	Yandy Díaz Y. Díaz	2	2025	TBR	35	32	9	1	0	2	3	0	5	35	16	3	0	0	0	.281	.343	.500	.843
15	Heliot Ramos H. Ramos	2	2025	SFG	16	15	3	0	0	2	1	0	7	16	9	2	0	0	0	.200	.250	.600	.850
16	Brenton Doyle B. Doyle	2	2025	COL	32	27	4	0	0	2	5	0	4	32	10	2	0	0	0	.148	.281	.370	.652
17	Taylor Ward T. Ward	2	2025	LAA	22	22	6	2	0	2	0	0	6	22	14	4	0	0	0	.273	.273	.636	.909
18	Jarren Duran J. Duran	2	2025	BOS	56	50	11	2	1	2	4	2	17	56	21	5	0	0	0	.220	.304	.420	.724
19	Lars Nootbaar L. Nootbaar	2	2025	STL	52	40	12	3	0	2	12	0	6	52	21	5	0	0	0	.300	.462	.525	.987
20	Ronald Acuña Jr. R. Acuña Jr.	1	2025	ATL	4	3	1	0	0	1	1	0	2	4	4	1	0	0	0	.333	.500	1.333	1.833
21	Jesús Sánchez J. Sánchez	1	2025	MIA	10	10	6	0	0	1	0	0	2	10	9	1	0	0	0	.600	.600	.900	1.500
22	Jeremy Peña J. Peña	1	2025	HOU	27	25	8	0	0	1	0	2	6	27	11	1	0	0	0	.320	.370	.440	.810
23	Jordan Beck J. Beck	1	2025	COL	13	13	4	1	0	1	0	0	7	13	8	2	0	0	0	.308	.308	.615	.923
24	Joshua Palacios J. Palacios	1	2025	CWS	7	6	1	0	0	1	1	0	3	7	4	1	0	0	0	.167	.286	.667	.952
25	Josh Smith J. Smith	1	2025	TEX	18	17	4	0	0	1	1	0	3	18	7	1	0	0	0	.235	.278	.412	.690