Since 1970, the San Diego Padres have lost the most games by a team, with 4,618 losses.

Interpreted as:

most regular-season loses by a team since 1970

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Padres	4,618	4,096	.530	8,716	.470	294,755	35,507	73,637	13,063	1,715	7,147	33,400	28,147	2,087	58,221	5,952	2,559	330,865	111,571	21,925	3,653	2,223	2,645	6,370	.250	.317	.379	.696
2	Royals	4,546	4,157	.522	8,704	.478	297,822	38,196	78,328	14,709	2,252	6,892	36,062	25,446	2,412	51,128	6,947	2,823	330,615	118,217	23,853	2,307	2,628	1,825	6,646	.263	.323	.397	.720
3	Tigers	4,514	4,192	.518	8,707	.482	297,597	39,261	77,192	13,791	1,972	8,947	37,252	28,218	2,286	56,789	4,377	2,336	332,650	121,768	24,710	2,104	2,445	1,808	6,701	.259	.326	.409	.735
4	Pirates	4,497	4,201	.517	8,704	.483	296,661	37,099	76,186	14,412	2,073	7,238	35,068	26,557	2,666	57,043	5,707	2,619	331,764	116,458	23,723	3,424	2,456	2,732	6,241	.257	.321	.393	.714
5	Nationals	4,478	4,228	.514	8,710	.486	294,654	36,585	74,844	14,481	1,755	7,465	34,389	27,689	2,579	56,113	6,484	2,719	330,994	115,230	23,701	3,820	2,252	2,829	6,358	.254	.321	.391	.712
6	Rangers	4,476	4,227	.514	8,708	.486	298,175	40,426	78,055	14,276	1,570	9,015	38,246	28,234	2,436	56,177	5,419	2,534	333,739	122,516	24,861	2,389	2,505	1,909	6,659	.262	.328	.411	.739
7	Cubs	4,451	4,249	.512	8,708	.488	296,928	38,258	76,103	14,007	1,793	8,488	36,103	28,069	2,419	57,884	4,876	2,380	333,145	119,160	24,288	3,456	2,273	2,667	6,413	.256	.323	.401	.725
8	White Sox	4,451	4,246	.512	8,706	.488	296,387	39,008	77,119	13,661	1,658	8,620	36,974	27,037	2,580	53,885	5,332	2,586	331,104	119,956	23,939	2,595	2,505	1,829	6,780	.260	.325	.405	.730
9	Brewers	4,450	4,260	.511	8,713	.489	295,864	38,827	75,888	14,203	1,728	8,568	36,806	28,370	2,672	57,781	5,795	2,668	332,379	119,251	24,499	3,088	2,385	2,114	6,494	.256	.325	.403	.728
10	Twins	4,445	4,261	.511	8,709	.489	298,873	39,579	79,047	14,811	1,903	7,721	37,326	27,662	2,571	53,492	4,744	2,388	333,821	120,827	24,435	2,193	2,522	1,988	7,186	.264	.330	.404	.734
11	Angels	4,364	4,349	.501	8,714	.499	296,633	38,673	76,701	13,549	1,497	8,171	36,471	27,682	2,513	53,702	5,524	2,737	332,053	117,757	23,217	2,812	2,413	2,079	6,864	.259	.325	.397	.722
12	Mets	4,360	4,344	.501	8,707	.499	294,963	36,913	74,393	13,665	1,552	7,748	34,826	28,821	2,529	56,442	5,455	2,383	332,127	114,406	22,965	3,466	2,348	2,781	6,498	.252	.322	.388	.710
13	Guardians	4,356	4,335	.501	8,693	.499	297,092	39,876	77,991	14,425	1,516	8,421	37,695	28,861	2,527	52,885	5,684	2,671	333,599	120,711	24,362	2,465	2,654	1,919	6,911	.263	.330	.406	.737
14	Phillies	4,346	4,365	.499	8,715	.501	297,178	38,465	76,007	14,334	1,992	8,114	36,319	29,452	2,512	58,647	5,863	2,204	334,647	118,667	24,440	3,126	2,379	2,890	6,150	.256	.326	.399	.725
15	Orioles	4,334	4,356	.499	8,694	.501	296,946	39,337	76,734	14,045	1,260	9,394	37,361	28,919	2,476	54,305	4,598	2,113	332,890	121,481	24,699	2,120	2,429	1,899	6,996	.258	.327	.409	.736
16	Reds	4,289	4,422	.492	8,717	.508	295,868	38,889	75,742	14,346	1,647	8,664	36,669	29,644	2,571	59,500	6,900	2,644	333,902	119,374	24,657	3,458	2,361	2,735	6,215	.256	.327	.403	.730
17	Giants	4,285	4,430	.492	8,716	.508	296,061	37,829	75,348	13,861	1,906	7,857	35,604	29,255	2,303	57,039	5,117	2,487	333,646	116,592	23,624	3,676	2,351	3,142	6,429	.255	.324	.394	.718
18	Athletics	4,249	4,462	.488	8,711	.512	295,012	39,317	74,308	13,668	1,365	8,902	37,099	30,772	2,558	56,782	6,089	2,560	333,145	117,412	23,935	2,289	2,514	1,739	6,664	.252	.325	.398	.723
19	Astros	4,241	4,471	.487	8,714	.513	296,319	38,150	76,242	14,317	1,853	7,700	35,993	28,268	2,580	55,543	6,612	2,791	332,985	117,365	23,870	3,395	2,423	2,678	6,431	.257	.325	.396	.721
20	Braves	4,167	4,528	.479	8,701	.521	295,893	38,679	76,128	13,774	1,447	8,802	36,602	29,021	2,173	56,053	4,846	2,430	332,882	119,202	24,023	3,559	2,236	2,696	6,684	.257	.326	.403	.729
21	Cardinals	4,126	4,576	.474	8,710	.526	296,518	38,781	77,647	14,310	1,927	7,257	36,537	28,725	2,457	54,263	6,685	2,790	333,707	117,582	23,494	3,516	2,491	2,906	6,623	.262	.330	.397	.726
22	Red Sox	4,016	4,693	.461	8,710	.539	301,022	42,997	81,534	16,704	1,630	9,200	40,793	30,554	2,644	54,041	4,069	1,954	338,886	129,098	27,534	1,975	2,691	2,322	7,382	.271	.341	.429	.769
23	Mariners	3,962	3,619	.523	7,583	.477	258,672	33,685	66,486	12,400	1,258	7,714	31,998	24,526	2,346	49,587	5,013	2,167	289,561	104,544	21,372	1,945	2,072	1,664	5,670	.257	.325	.404	.729
24	Dodgers	3,918	4,794	.450	8,715	.550	296,186	38,268	76,373	13,266	1,574	8,263	36,187	28,924	2,308	55,415	6,075	2,564	333,663	117,576	23,103	3,863	2,382	2,871	6,314	.258	.326	.397	.723
25	Blue Jays	3,805	3,777	.502	7,585	.498	259,870	35,055	67,575	13,505	1,491	8,239	33,249	24,095	2,421	48,864	4,567	1,962	290,003	108,779	23,235	1,496	2,121	1,397	5,916	.260	.326	.419	.745