Between the 1956 and 1960 seasons, the Kansas City Athletics lost the most games by a team, with 461 losses.

Interpreted as:

most regular-season losses by a team from 1956 to 1960

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Athletics	461	308	.599	773	.401	26,177	3,120	6,570	1,038	208	643	2,928	2,288	114	3,757	147	128	29,102	9,953	1,889	337	186	149	673	.251	.312	.380	.692
2	Senators	459	311	.596	773	.404	25,929	3,099	6,304	952	213	654	2,916	2,795	196	4,123	175	190	29,439	9,644	1,819	332	187	166	671	.243	.319	.372	.691
3	Cubs	442	328	.574	778	.426	26,525	3,241	6,609	1,054	222	753	3,054	2,423	146	4,426	205	139	29,600	10,366	2,029	313	193	276	546	.249	.313	.391	.704
4	Phillies	430	340	.558	773	.442	26,086	3,100	6,520	1,050	231	574	2,878	2,638	177	4,214	237	176	29,395	9,754	1,855	299	195	256	623	.250	.321	.374	.695
5	Giants	392	378	.509	772	.491	26,459	3,286	6,750	1,072	238	769	3,073	2,320	138	3,866	362	180	29,410	10,605	2,079	292	201	259	551	.255	.316	.401	.717
6	Tigers	386	384	.501	771	.499	26,319	3,408	6,843	1,046	192	685	3,196	2,825	154	3,400	227	154	29,890	10,328	1,923	387	205	183	605	.260	.333	.392	.725
7	Pirates	385	385	.500	776	.500	26,645	3,221	7,080	1,125	283	568	3,028	2,081	113	3,700	166	133	29,459	10,475	1,976	406	214	269	603	.266	.319	.393	.712
8	Red Sox	385	385	.500	772	.500	26,274	3,582	6,882	1,203	167	696	3,415	3,183	125	3,854	188	115	30,096	10,507	2,066	304	210	198	729	.262	.342	.400	.742
9	Orioles	385	382	.502	771	.498	25,843	2,922	6,348	972	148	518	2,718	2,680	140	3,642	202	160	29,268	9,170	1,638	416	189	173	646	.246	.318	.355	.673
10	Reds	382	388	.496	771	.504	26,530	3,621	6,989	1,182	179	832	3,421	2,657	175	3,898	295	161	29,949	11,025	2,193	363	224	246	560	.263	.332	.416	.748
11	Cardinals	378	392	.491	773	.509	26,609	3,314	7,060	1,142	228	623	3,080	2,515	121	3,470	256	210	29,672	10,527	1,993	242	185	309	638	.265	.329	.396	.725
12	Indians	362	406	.471	769	.529	26,104	3,500	6,705	1,042	125	748	3,293	2,641	177	3,658	221	189	29,526	10,241	1,915	385	219	164	563	.257	.327	.392	.719
13	Dodgers	354	418	.459	772	.541	26,022	3,445	6,630	978	208	772	3,228	2,814	130	4,164	377	222	29,600	10,340	1,958	434	200	266	632	.255	.328	.397	.726
14	White Sox	332	438	.431	774	.569	26,288	3,527	6,856	1,079	210	544	3,294	2,916	295	3,353	515	218	30,159	9,987	1,833	412	248	174	610	.261	.338	.380	.718
15	Braves	319	453	.413	775	.587	26,541	3,604	7,026	1,068	221	890	3,394	2,376	136	3,647	200	95	29,684	11,206	2,179	408	223	327	569	.265	.326	.422	.748
16	Yankees	307	463	.399	773	.601	26,546	3,772	7,037	1,044	228	845	3,535	2,707	138	3,926	230	152	29,999	11,072	2,117	404	204	223	550	.265	.334	.417	.751