Between the 2002 and 2006 seasons, the Tampa Bay Devil Rays lost the most games by a team, with 492 losses.

Interpreted as:

most regular-season losses by a team from 2002 to 2006

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Devil Rays	492	316	.609	808	.391	27,767	3,541	7,249	1,429	192	762	3,370	2,198	285	5,185	661	230	30,666	11,348	2,383	180	236	156	555	.261	.319	.409	.728
2	Royals	489	321	.604	810	.396	27,733	3,751	7,333	1,458	181	702	3,522	2,359	330	4,952	445	222	30,911	11,259	2,341	245	244	142	633	.264	.327	.406	.733
3	Tigers	473	336	.585	809	.415	27,739	3,538	7,252	1,327	215	849	3,362	2,138	259	5,449	375	225	30,607	11,556	2,391	234	237	129	606	.261	.318	.417	.734
4	Brewers	462	347	.571	809	.429	27,327	3,431	6,963	1,458	124	825	3,267	2,620	349	6,053	481	200	30,822	11,144	2,407	321	205	230	692	.255	.326	.408	.733
5	Pirates	455	353	.563	808	.437	27,525	3,445	7,127	1,383	159	727	3,281	2,411	416	5,516	376	179	30,915	11,009	2,269	344	219	206	609	.259	.326	.400	.726
6	Rockies	452	358	.558	810	.442	27,711	4,017	7,492	1,549	194	859	3,800	2,754	286	5,569	360	205	31,363	12,006	2,602	408	204	237	649	.270	.340	.433	.773
7	Orioles	450	360	.556	811	.444	28,053	3,749	7,531	1,491	116	839	3,561	2,332	302	4,624	504	194	31,138	11,771	2,446	217	234	157	667	.268	.329	.420	.748
8	Reds	434	376	.536	811	.464	27,577	3,722	6,987	1,449	97	984	3,562	2,931	347	6,344	469	167	31,354	11,582	2,530	325	174	232	584	.253	.331	.420	.751
9	Nationals	425	385	.525	810	.475	27,311	3,466	7,001	1,503	142	738	3,292	2,678	284	5,265	495	248	30,929	11,002	2,383	447	209	315	629	.256	.327	.403	.730
10	Diamondbacks	424	386	.523	810	.477	27,817	3,620	7,264	1,503	191	803	3,474	2,725	252	5,103	364	172	31,347	11,558	2,497	313	240	257	661	.261	.330	.416	.745
11	Padres	423	387	.522	810	.478	27,697	3,523	7,237	1,371	170	694	3,343	2,842	232	5,126	421	183	31,293	11,030	2,235	278	244	199	651	.261	.332	.398	.731
12	Cubs	421	389	.520	810	.480	27,814	3,638	7,292	1,463	151	967	3,473	2,380	225	5,355	388	168	31,015	11,958	2,581	389	207	211	638	.262	.323	.430	.753
13	Rangers	419	391	.517	810	.483	28,272	4,229	7,607	1,569	149	1,139	4,063	2,542	286	5,379	316	134	31,453	12,891	2,857	122	231	172	606	.269	.333	.456	.789
14	Indians	417	393	.515	810	.485	27,899	3,956	7,425	1,584	138	937	3,785	2,673	304	5,368	349	212	31,292	12,096	2,659	201	215	176	675	.266	.335	.434	.768
15	Mets	416	392	.515	808	.485	27,432	3,572	6,992	1,391	139	844	3,398	2,520	288	5,384	563	171	30,802	11,193	2,374	368	194	254	624	.255	.322	.408	.730
16	Mariners	414	396	.511	810	.489	28,029	3,762	7,532	1,406	160	729	3,548	2,577	269	5,010	563	221	31,313	11,445	2,295	197	241	244	616	.269	.334	.408	.742
17	Blue Jays	411	398	.508	809	.492	27,950	4,010	7,546	1,607	171	857	3,817	2,581	366	5,167	303	142	31,245	12,066	2,635	85	263	144	707	.270	.337	.432	.768
18	Marlins	396	414	.489	810	.511	27,476	3,643	7,292	1,462	182	761	3,430	2,618	317	5,243	629	286	31,009	11,401	2,405	376	222	266	638	.265	.334	.415	.749
19	Phillies	384	425	.475	809	.525	27,938	4,013	7,393	1,529	167	929	3,818	3,201	317	5,669	484	151	31,965	12,043	2,625	296	213	329	594	.265	.345	.431	.776
20	Dodgers	381	429	.470	810	.530	27,615	3,553	7,168	1,363	163	784	3,408	2,513	305	5,070	464	198	30,951	11,209	2,310	330	188	229	661	.260	.326	.406	.732
21	Astros	376	434	.464	811	.536	27,537	3,785	7,172	1,449	157	880	3,600	2,802	346	5,253	420	167	31,305	11,575	2,486	405	215	252	635	.260	.334	.420	.754
22	White Sox	371	439	.458	810	.542	27,709	4,121	7,437	1,420	110	1,115	3,960	2,510	307	4,956	460	226	31,014	12,422	2,645	246	242	129	602	.268	.333	.448	.782
23	Giants	370	437	.458	808	.542	27,433	3,783	7,250	1,491	175	852	3,597	2,839	279	4,607	299	141	31,181	11,647	2,518	407	223	437	691	.264	.337	.425	.761
24	Angels	358	452	.442	810	.558	28,073	3,950	7,738	1,468	161	770	3,744	2,321	274	4,347	698	272	31,144	11,838	2,399	229	247	227	604	.276	.334	.422	.756
25	Twins	354	455	.438	809	.562	28,026	3,838	7,628	1,520	171	790	3,619	2,472	292	4,948	492	238	31,226	11,860	2,481	195	241	203	708	.272	.335	.423	.758