Between the 2007 and 2011 seasons, the Pittsburgh Pirates lost the most games by a team, with 483 losses.

Interpreted as:

most regular-season losses by a team from 2007 to 2011

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Pirates	483	326	.597	809	.403	27,421	3,292	6,909	1,478	148	659	3,161	2,388	243	5,831	410	169	30,586	10,660	2,285	319	215	174	607	.252	.315	.389	.704
2	Orioles	473	336	.585	809	.415	27,947	3,600	7,397	1,472	113	798	3,437	2,426	234	5,118	458	175	30,969	11,489	2,383	133	229	149	689	.265	.326	.411	.737
3	Nationals	468	340	.579	808	.421	27,363	3,303	6,881	1,356	148	699	3,167	2,648	301	5,974	439	185	30,854	10,630	2,203	344	198	174	657	.251	.322	.388	.711
4	Royals	463	347	.572	810	.428	27,950	3,489	7,480	1,483	197	616	3,312	2,190	255	5,076	513	219	30,831	11,205	2,296	211	225	147	703	.268	.324	.401	.725
5	Mariners	448	362	.553	810	.447	27,700	3,174	7,094	1,329	99	647	3,017	2,121	225	5,308	527	174	30,458	10,562	2,075	205	207	181	607	.256	.312	.381	.693
6	Astros	444	365	.549	809	.451	27,542	3,304	7,094	1,408	137	679	3,156	2,260	229	5,273	510	198	30,564	10,813	2,224	341	192	180	652	.258	.317	.393	.710
7	Athletics	428	381	.529	809	.471	27,512	3,454	6,938	1,428	119	654	3,275	2,801	244	5,546	546	170	30,966	10,566	2,201	156	253	104	646	.252	.324	.384	.708
8	Padres	423	388	.522	811	.478	27,456	3,274	6,735	1,334	155	689	3,117	2,700	257	6,173	467	164	30,963	10,446	2,178	331	219	241	584	.245	.316	.380	.697
9	Indians	419	391	.517	810	.483	27,711	3,739	7,169	1,538	123	792	3,558	2,771	393	6,079	413	176	31,290	11,329	2,453	181	234	184	606	.259	.332	.409	.741
10	Reds	416	394	.514	810	.486	27,725	3,685	7,149	1,399	121	920	3,519	2,684	300	5,835	468	211	31,316	11,550	2,440	389	218	224	555	.258	.328	.417	.744
11	Marlins	415	394	.513	809	.487	27,737	3,676	7,155	1,506	158	869	3,499	2,688	320	6,548	443	164	31,288	11,584	2,533	331	212	222	533	.258	.328	.418	.746
12	Diamondbacks	409	401	.505	810	.495	27,266	3,596	6,836	1,505	203	855	3,449	2,810	243	6,474	488	183	30,803	11,312	2,563	268	216	234	514	.251	.324	.415	.739
13	Mets	407	403	.502	810	.498	27,729	3,648	7,344	1,438	193	680	3,444	2,767	226	5,113	720	205	31,366	11,208	2,311	377	267	293	600	.265	.334	.404	.738
14	White Sox	404	407	.498	811	.502	27,443	3,634	7,063	1,306	90	940	3,482	2,548	340	5,098	499	255	30,741	11,369	2,336	205	205	145	707	.257	.326	.414	.740
15	Giants	401	409	.495	810	.505	27,548	3,247	7,008	1,419	171	630	3,053	2,311	239	5,330	445	190	30,646	10,659	2,220	329	219	260	671	.254	.315	.387	.702
16	Twins	401	411	.494	812	.506	27,826	3,764	7,449	1,419	191	646	3,553	2,625	205	4,854	459	171	31,114	11,188	2,256	206	252	204	712	.268	.333	.402	.735
17	Blue Jays	400	410	.494	810	.506	27,789	3,763	7,151	1,590	124	943	3,602	2,598	254	5,358	399	144	31,027	11,818	2,657	152	234	155	629	.257	.324	.425	.749
18	Rockies	399	412	.492	811	.508	27,720	3,916	7,342	1,467	208	857	3,735	2,992	266	6,113	564	206	31,591	11,796	2,532	380	233	234	585	.265	.340	.426	.765
19	Cubs	397	411	.491	808	.509	27,778	3,653	7,317	1,545	141	793	3,468	2,632	258	5,863	353	155	31,163	11,523	2,479	298	197	207	642	.263	.331	.415	.746
20	Braves	388	422	.479	810	.521	27,823	3,677	7,291	1,500	121	767	3,507	2,892	222	5,636	320	156	31,493	11,334	2,388	363	193	248	671	.262	.334	.407	.742
21	Tigers	387	424	.477	811	.523	28,144	3,989	7,679	1,495	192	881	3,822	2,653	241	5,534	356	144	31,470	12,201	2,568	205	227	195	663	.273	.338	.434	.772
22	Dodgers	386	423	.477	809	.523	27,574	3,526	7,273	1,332	160	648	3,338	2,692	238	5,235	597	231	31,090	10,869	2,140	356	230	297	634	.264	.332	.394	.726
23	Brewers	384	426	.474	810	.526	27,652	3,807	7,193	1,484	173	978	3,656	2,688	353	5,870	447	164	31,201	11,957	2,635	292	216	236	566	.260	.331	.432	.764
24	Rangers	383	427	.473	810	.527	28,103	4,143	7,670	1,548	155	969	3,930	2,556	240	5,600	584	179	31,375	12,435	2,672	226	250	165	607	.273	.336	.442	.778
25	Cardinals	379	431	.468	810	.532	27,704	3,732	7,503	1,449	108	787	3,543	2,694	251	4,940	340	176	31,227	11,529	2,344	357	221	325	724	.271	.338	.416	.755