Since 2010, the Colorado Rockies have lost the most games by a team, with 1,362 losses.

Interpreted as:

most regular-season losses by a team since 2010

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	1,362	1,062	.562	2,424	.438	82,916	11,196	21,621	4,300	607	2,689	10,708	7,067	696	20,416	1,278	515	91,967	35,202	7,596	687	601	476	1,776	.261	.322	.425	.746
2	Marlins	1,357	1,064	.561	2,421	.439	82,026	9,544	20,302	3,771	437	2,136	9,079	6,822	825	19,971	1,410	486	90,887	31,355	6,344	660	554	449	1,843	.248	.310	.382	.692
3	White Sox	1,338	1,086	.552	2,424	.448	82,311	10,058	20,575	3,848	342	2,514	9,620	6,537	943	19,625	1,289	537	90,760	32,649	6,704	416	553	274	1,828	.250	.311	.397	.707
4	Royals	1,313	1,112	.541	2,425	.459	82,617	10,124	21,197	4,114	508	2,159	9,645	6,277	786	17,353	1,901	589	90,811	32,804	6,781	449	682	322	1,798	.257	.313	.397	.710
5	Pirates	1,298	1,125	.536	2,424	.464	81,663	9,810	20,004	3,951	467	2,210	9,366	7,341	926	19,915	1,343	580	91,143	31,519	6,628	641	572	460	1,695	.245	.312	.386	.698
6	Orioles	1,273	1,150	.525	2,423	.475	82,790	10,627	20,741	4,007	276	3,036	10,183	6,691	856	19,733	1,045	379	91,222	34,408	7,319	308	577	291	1,788	.251	.311	.416	.727
7	Reds	1,265	1,160	.522	2,425	.478	81,803	10,593	20,296	3,937	382	2,721	10,108	7,715	1,067	20,101	1,608	588	91,874	33,160	7,040	703	586	460	1,675	.248	.319	.405	.724
8	Diamondbacks	1,261	1,164	.520	2,425	.480	82,597	11,043	20,712	4,286	583	2,618	10,514	7,914	825	19,911	1,520	494	92,606	34,018	7,487	609	661	511	1,695	.251	.320	.412	.732
9	Twins	1,256	1,168	.518	2,424	.482	82,680	10,956	20,806	4,278	387	2,715	10,444	7,754	892	19,575	1,082	417	92,250	34,003	7,380	311	613	343	1,733	.252	.320	.411	.732
10	Padres	1,253	1,171	.517	2,424	.483	81,123	9,955	19,611	3,762	407	2,400	9,461	7,609	774	19,968	1,655	539	90,755	31,387	6,569	656	593	447	1,652	.242	.311	.387	.698
11	Tigers	1,249	1,171	.516	2,420	.484	82,617	10,531	21,181	4,098	516	2,450	10,095	7,140	739	19,697	1,006	409	91,445	33,661	7,064	308	641	401	1,844	.256	.319	.407	.726
12	Athletics	1,245	1,181	.513	2,426	.487	81,893	10,491	19,834	4,077	370	2,684	9,983	7,878	872	19,399	1,315	394	91,548	32,703	7,131	292	613	278	1,809	.242	.313	.399	.713
13	Angels	1,243	1,181	.513	2,424	.487	82,000	10,631	20,380	3,889	357	2,768	10,135	7,332	931	18,961	1,377	526	91,271	33,287	7,014	392	616	441	1,850	.249	.315	.406	.721
14	Mariners	1,235	1,189	.509	2,424	.491	81,822	10,081	19,671	3,719	295	2,706	9,632	7,561	982	20,510	1,464	521	91,265	32,098	6,720	346	554	329	1,633	.240	.310	.392	.703
15	Nationals	1,218	1,205	.503	2,423	.497	81,868	10,678	20,773	4,095	367	2,591	10,160	7,631	907	18,958	1,626	521	91,722	33,375	7,053	691	625	513	1,764	.254	.322	.408	.730
16	Rangers	1,217	1,209	.502	2,426	.498	82,525	11,192	20,928	3,971	359	2,839	10,631	7,349	922	19,130	1,680	582	91,843	34,134	7,169	401	646	359	1,662	.254	.319	.414	.733
17	Mets	1,209	1,216	.499	2,425	.501	81,962	10,433	20,255	4,023	369	2,640	10,013	7,795	1,106	19,338	1,266	423	92,000	32,936	7,032	562	575	521	1,752	.247	.319	.402	.721
18	Cubs	1,205	1,220	.497	2,426	.503	81,998	10,760	20,281	4,072	441	2,731	10,245	7,923	1,085	20,601	1,293	502	92,117	33,428	7,244	553	558	481	1,690	.247	.320	.408	.728
19	Phillies	1,200	1,224	.495	2,424	.505	82,405	10,580	20,539	4,002	452	2,613	10,104	7,518	884	19,591	1,482	398	91,937	33,284	7,067	580	550	524	1,658	.249	.317	.404	.721
20	Blue Jays	1,197	1,227	.494	2,424	.506	82,354	11,207	20,722	4,280	280	3,137	10,716	7,814	802	18,767	1,198	422	91,879	34,973	7,697	316	593	289	1,877	.252	.320	.425	.745
21	Giants	1,176	1,249	.485	2,425	.515	82,337	10,195	20,504	4,103	482	2,264	9,711	7,479	798	19,202	1,072	436	91,864	32,363	6,849	585	665	507	1,826	.249	.315	.393	.708
22	Astros	1,170	1,253	.483	2,423	.517	82,368	10,978	20,969	4,194	324	2,845	10,467	7,526	872	18,835	1,420	525	91,809	34,346	7,363	413	630	341	1,891	.255	.321	.417	.738
23	Brewers	1,150	1,275	.474	2,425	.526	81,673	10,790	20,282	3,957	388	2,830	10,290	7,948	982	20,495	1,844	538	91,768	33,505	7,175	618	547	458	1,780	.248	.320	.410	.731
24	Red Sox	1,149	1,278	.473	2,427	.527	84,197	11,973	22,232	4,984	364	2,823	11,396	7,954	861	19,388	1,370	419	93,927	36,413	8,171	254	661	508	1,873	.264	.331	.432	.764
25	Guardians	1,144	1,276	.473	2,420	.527	81,790	10,668	20,466	4,238	354	2,504	10,144	7,821	891	18,234	1,687	494	91,619	32,924	7,096	428	689	422	1,739	.250	.320	.403	.723