most losses in a career by an active pitcher

Justin Verlander has lost the most career games by an active pitcher, with 151 games.

Interpreted as:

most regular-season losses in a career by an active pitcher

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Justin Verlander J. Verlander	151	262	.366	537	.634	537	3.32	3,463	26	9	0	3472.1	2,950	1,280	1,385	364	974	116	0	27	14,192	97	8.98	2.52	3.56	0.94	24.4	6.9	1.13	.279	3.59	79	3.43	81	7.65	303.4
2	Patrick Corbin P. Corbin	137	107	.561	355	.439	337	4.49	1,782	7	2	2	1963.2	2,084	980	1,054	274	602	49	9	23	8,441	64	8.17	2.76	2.96	1.26	21.1	7.1	1.37	.316	4.83	107	4.14	99	9.55	5.9
3	Charlie Morton C. Morton	130	142	.478	400	.522	393	4.06	2,121	3	2	0	2192.2	2,066	990	1,089	213	819	191	1	25	9,409	70	8.71	3.36	2.59	0.87	22.5	8.7	1.32	.306	4.47	101	3.84	96	8.48	46.8
4	Max Scherzer M. Scherzer	112	215	.343	467	.657	458	3.16	3,408	12	5	0	2881.0	2,349	1,012	1,085	337	756	112	2	20	11,640	78	10.65	2.36	4.51	1.05	29.3	6.5	1.08	.286	3.39	76	3.18	77	7.34	307.9
5	Kevin Gausman K. Gausman	108	107	.502	344	.498	305	3.88	1,849	3	1	0	1804.0	1,753	777	832	224	509	37	11	10	7,559	63	9.22	2.54	3.63	1.12	24.5	6.7	1.25	.310	4.15	94	3.62	86	8.75	118.6
6	Jose Quintana J. Quintana	105	107	.495	369	.505	343	3.72	1,763	2	2	0	2024.0	1,974	837	906	207	616	54	7	23	8,488	75	7.84	2.74	2.86	0.92	20.8	7.3	1.28	.302	4.03	90	3.71	89	8.78	97.4
7	Wade Miley W. Miley	99	109	.476	320	.524	312	4.09	1,368	3	2	0	1757.1	1,783	798	855	198	611	46	3	10	7,519	58	7.01	3.13	2.24	1.01	18.2	8.1	1.36	.299	4.38	98	4.16	101	9.13	-6.3
8	Sonny Gray S. Gray	96	117	.451	322	.549	313	3.52	1,814	6	4	0	1822.0	1,574	712	780	177	600	57	2	5	7,546	105	8.96	2.96	3.02	0.87	24.0	8.0	1.19	.285	3.85	85	3.51	85	7.77	130
9	Clayton Kershaw C. Kershaw	94	215	.304	439	.696	436	2.51	2,992	25	15	0	2775.1	2,122	774	849	231	690	44	1	28	10,952	105	9.70	2.24	4.34	0.75	27.3	6.3	1.01	.270	2.75	64	2.84	70	6.88	366.2
10	Yu Darvish Y. Darvish	88	110	.444	282	.556	282	3.58	2,007	2	1	0	1706.0	1,394	678	712	217	544	77	0	8	7,009	79	10.59	2.87	3.69	1.14	28.6	7.8	1.14	.283	3.76	85	3.53	84	7.35	125.8
11	Martín Pérez M. Pérez	88	91	.492	318	.508	273	4.43	1,127	4	3	0	1595.2	1,724	785	867	186	579	51	14	11	6,925	43	6.36	3.27	1.95	1.05	16.3	8.4	1.44	.309	4.89	101	4.44	103	9.72	-23.6
12	Kyle Hendricks K. Hendricks	87	102	.460	291	.540	285	3.74	1,314	6	4	0	1662.1	1,586	691	743	198	387	68	4	19	6,869	12	7.11	2.10	3.40	1.07	19.1	5.6	1.19	.283	4.02	91	3.95	96	8.59	33.5
13	Chris Sale C. Sale	87	143	.378	387	.622	307	3.02	2,528	16	3	12	2047.2	1,668	686	739	209	481	126	25	15	8,249	47	11.11	2.11	5.26	0.92	30.6	5.8	1.05	.297	3.25	71	2.88	69	7.33	296.9
14	Aaron Nola A. Nola	86	105	.450	277	.550	277	3.78	1,831	6	4	0	1671.0	1,482	701	739	210	437	55	0	16	6,855	18	9.86	2.35	4.19	1.13	26.7	6.4	1.15	.294	3.98	90	3.49	81	7.98	145.9
15	Marcus Stroman M. Stroman	86	87	.497	264	.503	255	3.77	1,211	4	2	2	1467.2	1,436	615	684	141	443	39	3	5	6,145	47	7.43	2.72	2.73	0.86	19.7	7.2	1.28	.300	4.19	91	3.74	89	8.81	79.5
16	Nathan Eovaldi N. Eovaldi	84	95	.469	306	.531	287	3.96	1,431	5	3	0	1641.2	1,617	723	766	182	455	52	5	16	6,894	52	7.85	2.49	3.15	1.00	20.8	6.6	1.26	.301	4.20	97	3.76	92	8.86	59.3
17	Luis Castillo L. Castillo	81	76	.516	226	.484	226	3.54	1,403	1	0	0	1315.1	1,118	518	566	162	435	43	0	8	5,438	17	9.60	2.98	3.23	1.11	25.8	8.0	1.18	.282	3.87	85	3.73	88	7.65	73.4
18	Kyle Freeland K. Freeland	81	60	.574	219	.426	214	4.52	877	0	0	0	1171.1	1,299	588	639	166	369	43	0	11	5,085	16	6.74	2.84	2.38	1.28	17.2	7.3	1.42	.312	4.91	94	4.56	103	9.98	-15.8
19	José Berríos J. Berríos	80	102	.440	260	.560	259	4.04	1,424	5	1	0	1500.2	1,396	673	717	205	453	95	0	7	6,300	35	8.54	2.72	3.14	1.23	22.6	7.2	1.23	.289	4.30	96	4.14	98	8.37	20.8
20	Gerrit Cole G. Cole	80	153	.343	317	.657	317	3.18	2,251	8	5	0	1954.0	1,627	690	740	217	500	61	0	8	7,861	58	10.37	2.30	4.50	1.00	28.6	6.4	1.09	.292	3.41	79	3.16	77	7.49	213.5
21	Alex Cobb A. Cobb	76	78	.494	233	.506	233	3.84	1,108	6	2	0	1327.2	1,307	566	620	140	383	47	0	15	5,577	51	7.51	2.60	2.89	0.95	19.9	6.9	1.27	.299	4.20	94	3.81	92	8.86	43.8
22	Robbie Ray R. Ray	75	85	.469	249	.531	245	3.90	1,652	1	1	0	1351.0	1,173	586	625	203	571	47	1	19	5,719	57	11.01	3.80	2.89	1.35	28.9	10.0	1.29	.299	4.16	93	4.02	98	7.81	10.9
23	Nick Pivetta N. Pivetta	73	63	.537	238	.463	193	4.67	1,230	2	0	3	1113.1	1,045	578	604	186	401	32	13	6	4,725	52	9.94	3.24	3.07	1.50	26.0	8.5	1.30	.299	4.88	109	4.29	101	8.45	-6.6
24	Matthew Boyd M. Boyd	72	52	.581	197	.419	183	4.67	970	2	1	0	994.0	976	516	552	167	315	49	2	7	4,242	31	8.78	2.85	3.08	1.51	22.9	7.4	1.30	.295	5.00	108	4.49	104	8.84	-20.1
25	Zack Wheeler Z. Wheeler	72	110	.396	274	.604	274	3.29	1,743	4	3	0	1671.2	1,431	612	663	157	479	70	0	14	6,860	40	9.38	2.58	3.64	0.85	25.4	7.0	1.14	.289	3.57	83	3.28	80	7.70	159