Since 2020, Patrick Corbin has lost the most games, with 81 games.

Interpreted as:

most regular-season losses by a player in MLB since 2020

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Patrick Corbin P. Corbin	81	40	.669	168	.331	167	5.41	725	2	0	0	900.0	1,066	541	574	153	289	20	1	6	3,976	18	7.25	2.89	2.51	1.53	18.2	7.3	1.51	.327	5.74	130	4.79	113	10.66	-54.1
2	Kyle Freeland K. Freeland	61	33	.649	148	.351	148	4.77	585	0	0	0	797.2	917	423	463	121	220	31	0	3	3,461	10	6.60	2.48	2.66	1.37	16.9	6.4	1.43	.318	5.22	100	4.61	105	10.35	-16.7
3	Mitch Keller M. Keller	60	41	.594	154	.406	152	4.36	772	2	1	0	830.0	842	402	431	97	283	57	0	2	3,591	17	8.37	3.07	2.73	1.05	21.5	7.9	1.36	.313	4.67	102	4.05	97	9.13	10.6
4	Luis Castillo L. Castillo	57	55	.509	165	.491	165	3.49	1,004	1	0	0	961.0	847	373	411	113	293	33	0	6	3,976	8	9.40	2.74	3.43	1.06	25.3	7.4	1.19	.290	3.85	86	3.62	88	7.93	54.7
5	Brady Singer B. Singer	56	50	.528	159	.472	156	4.23	808	1	0	0	855.0	845	402	427	101	274	56	2	1	3,650	19	8.51	2.88	2.95	1.06	22.1	7.5	1.31	.309	4.49	97	3.97	95	8.89	21.4
6	Aaron Nola A. Nola	54	56	.491	158	.509	158	4.11	1,050	6	4	0	944.1	853	431	455	134	214	28	0	4	3,862	8	10.01	2.04	4.91	1.28	27.2	5.5	1.13	.295	4.34	97	3.56	83	8.13	73.5
7	Miles Mikolas M. Mikolas	51	41	.554	140	.446	139	4.50	543	1	0	0	776.1	802	388	408	112	151	24	0	1	3,240	7	6.29	1.75	3.60	1.30	16.8	4.7	1.23	.286	4.73	110	4.32	106	9.30	-22.9
8	Dylan Cease D. Cease	51	61	.455	174	.545	174	3.73	1,150	3	3	0	942.1	776	391	431	106	395	33	0	8	3,978	51	10.98	3.77	2.91	1.01	28.9	9.9	1.24	.292	4.12	90	3.55	83	7.41	71.3
9	Sandy Alcantara S. Alcantara	50	44	.532	131	.468	131	3.60	740	10	2	0	835.2	721	334	372	85	220	34	0	3	3,402	22	7.97	2.37	3.36	0.92	21.8	6.5	1.13	.274	4.01	84	3.62	87	7.77	48.5
10	Kevin Gausman K. Gausman	50	65	.435	170	.565	168	3.36	1,099	3	2	0	985.1	871	368	401	103	255	13	1	3	4,039	20	10.04	2.33	4.31	0.94	27.2	6.3	1.14	.299	3.66	83	3.11	75	7.96	112.9
11	Tyler Anderson T. Anderson	48	44	.522	158	.478	152	4.11	678	1	0	0	862.0	812	394	422	118	291	31	0	9	3,663	22	7.08	3.04	2.33	1.23	18.5	7.9	1.28	.273	4.41	98	4.49	106	8.48	-24.3
12	José Berríos J. Berríos	48	65	.425	171	.575	170	4.01	896	2	0	0	975.0	916	434	461	141	278	58	0	6	4,071	17	8.27	2.57	3.22	1.30	22.0	6.8	1.22	.287	4.26	98	4.24	102	8.46	-6.6
13	Erick Fedde E. Fedde	48	28	.632	130	.368	117	4.84	487	1	1	0	629.0	641	338	355	93	247	15	3	9	2,734	14	6.97	3.53	1.97	1.33	17.8	9.0	1.41	.290	5.08	117	4.77	115	9.17	-42.4
14	Kyle Hendricks K. Hendricks	48	42	.533	144	.467	139	4.59	555	2	1	0	779.0	810	397	420	115	189	29	4	7	3,296	3	6.41	2.18	2.94	1.33	16.8	5.7	1.28	.289	4.85	111	4.50	108	9.36	-27
15	Germán Márquez G. Márquez	48	30	.615	107	.385	107	5.00	502	3	1	0	593.2	620	330	362	85	207	14	0	6	2,570	33	7.61	3.14	2.43	1.29	19.5	8.1	1.39	.304	5.49	105	4.43	102	9.40	-1.7
16	Logan Webb L. Webb	48	67	.417	172	.583	169	3.31	957	3	2	0	1022.2	976	376	415	69	236	35	0	4	4,176	18	8.42	2.08	4.06	0.61	22.9	5.7	1.19	.315	3.65	81	2.96	74	8.59	121.5
17	Yusei Kikuchi Y. Kikuchi	47	42	.528	167	.472	155	4.27	895	0	0	1	826.1	791	392	426	129	306	23	4	3	3,522	31	9.75	3.33	2.92	1.41	25.4	8.7	1.33	.305	4.64	104	4.22	101	8.62	-3.4
18	Jordan Lyles J. Lyles	47	29	.618	112	.382	102	5.41	449	4	0	0	599.1	635	360	377	115	178	23	4	0	2,576	27	6.74	2.67	2.52	1.73	17.4	6.9	1.36	.287	5.66	126	5.18	122	9.54	-63
19	Charlie Morton C. Morton	47	56	.456	166	.544	160	4.23	962	0	0	0	866.1	784	407	432	108	351	83	1	6	3,725	19	9.99	3.65	2.74	1.12	25.8	9.4	1.31	.304	4.49	101	4.07	99	8.14	3.7
20	Chris Bassitt C. Bassitt	46	69	.400	164	.600	163	3.57	901	3	2	0	943.1	872	374	403	108	286	67	0	5	3,963	22	8.60	2.73	3.15	1.03	22.7	7.2	1.23	.294	3.84	88	3.87	93	8.32	29.2
21	Andrew Heaney A. Heaney	46	36	.561	151	.439	131	4.65	726	0	0	0	698.2	684	361	389	123	220	48	4	2	3,017	13	9.35	2.83	3.30	1.58	24.1	7.3	1.29	.295	5.01	110	4.53	107	8.81	-20.6
22	Nick Pivetta N. Pivetta	46	50	.479	165	.521	138	4.06	912	1	0	2	820.1	697	370	385	128	280	21	4	5	3,408	30	10.01	3.07	3.26	1.40	26.8	8.2	1.19	.275	4.22	94	4.06	98	7.65	9.5
23	Austin Gomber A. Gomber	45	29	.608	139	.392	113	5.15	472	0	0	0	630.2	682	361	378	113	188	12	4	4	2,707	18	6.74	2.68	2.51	1.61	17.4	6.9	1.38	.296	5.39	108	4.95	113	9.73	-37.9
24	Zac Gallen Z. Gallen	45	63	.417	161	.583	161	3.65	964	2	2	0	927.1	781	376	399	109	288	32	0	2	3,808	30	9.36	2.80	3.35	1.06	25.3	7.6	1.15	.278	3.87	86	3.65	90	7.58	42.6
25	Framber Valdez F. Valdez	44	73	.376	154	.624	153	3.23	951	9	3	0	973.0	816	349	383	75	321	50	0	1	4,000	52	8.80	2.97	2.96	0.69	23.8	8.0	1.17	.285	3.54	79	3.35	81	7.55	83.5