Between October 28, 2020 and October 28, 2025, the Colorado Rockies have lost the most games by a team, with 504 losses.

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Rockies	504	305	.623	809	.377	27,272	3,437	6,714	1,390	161	833	3,299	2,239	277	7,377	369	138	30,094	10,925	2,384	109	197	67	605	.246	.308	.401	.708
2	Nationals	482	328	.595	810	.405	27,137	3,374	6,760	1,328	112	765	3,209	2,337	352	6,244	613	207	30,134	10,607	2,205	122	186	83	629	.249	.315	.391	.706
3	White Sox	474	336	.585	810	.415	27,229	3,277	6,553	1,280	63	808	3,139	2,244	295	6,849	376	106	30,030	10,383	2,151	96	166	54	612	.241	.304	.381	.685
4	Athletics	469	341	.579	810	.421	26,999	3,272	6,288	1,281	90	922	3,126	2,471	339	7,142	493	128	30,103	10,515	2,293	104	190	61	555	.233	.303	.389	.693
5	Pirates	464	346	.573	810	.427	26,925	3,140	6,267	1,229	133	718	2,991	2,576	275	7,217	487	158	30,071	9,916	2,080	104	191	80	513	.233	.304	.368	.673
6	Angels	452	358	.558	810	.442	27,080	3,393	6,378	1,171	112	1,002	3,244	2,397	365	7,500	449	161	30,096	10,779	2,285	88	166	116	534	.236	.305	.398	.703
7	Marlins	449	361	.554	810	.446	27,305	3,221	6,643	1,247	118	772	3,069	2,201	294	6,926	577	166	30,088	10,442	2,137	99	189	83	587	.243	.305	.382	.687
8	Royals	447	363	.552	810	.448	27,144	3,388	6,686	1,312	167	793	3,260	2,156	295	6,198	636	187	29,961	10,711	2,272	117	249	68	488	.246	.306	.395	.701
9	Rangers	433	377	.535	810	.465	27,393	3,580	6,609	1,240	92	949	3,423	2,464	276	6,854	544	147	30,372	10,880	2,281	53	186	78	486	.241	.308	.397	.706
10	Diamondbacks	431	379	.532	810	.468	27,278	3,804	6,717	1,392	174	908	3,621	2,722	337	6,634	552	140	30,765	11,181	2,474	170	258	87	538	.246	.320	.410	.729
11	Reds	423	387	.522	810	.478	27,075	3,632	6,550	1,305	120	917	3,461	2,584	427	7,229	596	180	30,376	10,846	2,342	96	194	58	549	.242	.316	.401	.716
12	Twins	420	390	.519	810	.481	27,318	3,623	6,650	1,362	102	1,013	3,448	2,605	413	7,090	357	107	30,585	11,255	2,477	48	201	66	594	.243	.317	.412	.729
13	Tigers	416	394	.514	810	.486	27,130	3,355	6,450	1,204	176	814	3,220	2,365	268	7,315	357	112	30,028	10,448	2,194	49	216	50	508	.238	.303	.385	.688
14	Orioles	408	402	.504	810	.496	27,327	3,603	6,640	1,363	120	975	3,453	2,412	332	7,030	482	140	30,335	11,168	2,458	57	207	65	487	.243	.310	.409	.719
15	Cubs	407	403	.502	810	.498	27,171	3,710	6,636	1,279	145	958	3,545	2,679	369	7,074	641	173	30,534	11,079	2,382	101	214	79	519	.244	.318	.408	.726
16	Cardinals	395	415	.488	810	.512	27,297	3,558	6,759	1,336	85	917	3,406	2,541	380	6,532	466	132	30,531	11,016	2,338	100	213	87	539	.248	.318	.404	.722
17	Red Sox	392	418	.484	810	.516	27,735	3,873	7,116	1,656	108	936	3,693	2,487	340	7,120	487	149	30,823	11,796	2,700	53	208	114	558	.257	.323	.425	.748
18	Mets	385	425	.475	810	.525	27,029	3,659	6,657	1,262	100	993	3,512	2,607	492	6,647	487	103	30,420	11,098	2,355	98	194	100	574	.246	.322	.411	.732
19	Giants	382	428	.472	810	.528	27,101	3,592	6,456	1,287	114	948	3,435	2,765	358	7,247	323	92	30,536	10,815	2,349	91	221	107	560	.238	.315	.399	.714
20	Guardians	381	428	.471	809	.529	27,023	3,428	6,520	1,303	118	807	3,261	2,334	347	6,191	656	160	30,029	10,480	2,228	100	225	154	517	.241	.307	.388	.695
21	Padres	377	433	.465	810	.535	27,203	3,648	6,764	1,334	89	880	3,485	2,781	297	6,200	522	151	30,644	10,916	2,303	151	212	118	586	.249	.323	.401	.724
22	Blue Jays	370	440	.457	810	.543	27,510	3,836	7,109	1,458	83	997	3,688	2,576	318	6,095	396	130	30,665	11,724	2,538	71	190	84	636	.258	.327	.426	.753
23	Rays	368	442	.454	810	.546	27,289	3,701	6,677	1,353	116	920	3,515	2,560	348	7,239	715	221	30,427	11,022	2,389	45	185	72	473	.245	.315	.404	.719
24	Mariners	367	443	.453	810	.547	27,062	3,587	6,318	1,206	64	1,029	3,440	2,794	477	7,563	566	146	30,583	10,739	2,299	60	190	81	515	.233	.314	.397	.711
25	Phillies	360	450	.444	810	.556	27,454	3,839	6,947	1,361	130	1,033	3,693	2,624	310	6,953	595	133	30,694	11,667	2,524	95	211	114	531	.253	.323	.425	.748