Since 2017, the Chicago White Sox lost the most games by a team, with 783 losses.

	TEAM	L	W	L%	G	W%	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	White Sox	783	572	.578	1,355	.422	45,841	5,653	11,274	2,149	166	1,454	5,418	3,627	527	11,960	628	214	50,463	18,117	3,769	192	276	103	993	.246	.307	.395	.702
2	Rockies	776	580	.572	1,356	.428	46,064	6,151	11,672	2,370	298	1,522	5,907	3,915	425	12,228	636	245	51,012	19,204	4,190	271	337	188	1,014	.253	.316	.417	.732
3	Royals	770	586	.568	1,356	.432	45,669	5,667	11,313	2,233	267	1,371	5,418	3,601	484	10,606	1,010	315	50,322	18,193	3,871	190	378	120	912	.248	.307	.398	.706
4	Marlins	766	589	.565	1,355	.435	45,842	5,466	11,241	2,087	196	1,300	5,206	3,728	532	11,598	819	271	50,623	17,620	3,583	218	303	179	1,001	.245	.308	.384	.692
5	Pirates	764	591	.564	1,355	.436	45,419	5,477	10,901	2,159	251	1,248	5,223	4,161	496	11,393	704	272	50,627	17,306	3,658	231	320	204	907	.240	.309	.381	.690
6	Tigers	761	592	.562	1,353	.438	45,622	5,551	11,007	2,147	299	1,347	5,314	3,834	439	12,131	568	202	50,319	17,793	3,793	85	339	104	896	.241	.304	.390	.694
7	Orioles	753	603	.555	1,356	.445	46,106	5,971	11,328	2,228	179	1,685	5,721	3,852	537	11,803	698	219	50,938	18,969	4,092	117	326	109	900	.246	.309	.411	.721
8	Angels	740	616	.546	1,356	.454	45,529	5,887	10,884	2,036	178	1,707	5,631	4,259	600	11,764	760	255	50,821	18,397	3,921	122	311	221	978	.239	.311	.404	.715
9	Rangers	734	622	.541	1,356	.459	45,752	6,150	11,037	2,137	170	1,665	5,844	4,264	536	11,957	911	278	51,005	18,509	3,972	132	321	133	831	.241	.311	.405	.716
10	Nationals	730	626	.538	1,356	.462	45,687	6,130	11,618	2,333	207	1,468	5,845	4,286	555	10,619	989	311	51,121	18,769	4,008	259	334	244	1,008	.254	.324	.411	.734
11	Reds	728	628	.537	1,356	.463	45,383	6,025	11,062	2,116	213	1,625	5,757	4,439	686	11,904	902	299	51,044	18,479	3,954	225	311	163	948	.244	.319	.407	.726
12	Athletics	710	646	.524	1,356	.476	45,511	5,943	10,853	2,291	159	1,711	5,676	4,402	584	11,876	660	195	50,953	18,595	4,161	132	324	116	1,004	.238	.312	.409	.720
13	Diamondbacks	692	664	.510	1,356	.490	45,893	6,391	11,306	2,354	315	1,582	6,088	4,581	549	11,371	845	216	51,695	19,036	4,251	279	393	208	911	.246	.320	.415	.734
14	Giants	685	671	.505	1,356	.495	45,791	5,811	11,026	2,239	212	1,457	5,565	4,350	520	11,852	542	196	51,214	18,060	3,908	183	370	218	971	.241	.311	.394	.706
15	Padres	679	677	.501	1,356	.499	45,408	5,876	11,091	2,138	186	1,545	5,608	4,420	464	11,282	831	270	50,905	18,236	3,869	287	326	191	964	.244	.316	.402	.717
16	Mets	672	684	.496	1,356	.504	45,654	6,147	11,314	2,199	186	1,715	5,919	4,415	762	11,224	692	202	51,335	19,030	4,100	191	313	209	990	.248	.322	.417	.739
17	Blue Jays	668	688	.493	1,356	.507	46,002	6,266	11,580	2,421	129	1,771	6,014	4,329	484	10,831	580	210	51,242	19,572	4,321	123	304	125	1,053	.252	.321	.425	.746
18	Twins	666	690	.491	1,356	.509	46,070	6,384	11,488	2,364	181	1,783	6,097	4,443	606	11,622	541	190	51,557	19,563	4,328	105	333	147	927	.249	.321	.425	.746
19	Phillies	651	705	.480	1,356	.520	45,933	6,286	11,468	2,290	232	1,690	6,031	4,491	506	11,823	836	210	51,443	19,292	4,212	190	323	235	898	.250	.321	.420	.741
20	Mariners	651	705	.480	1,356	.520	45,555	6,026	10,896	2,085	146	1,704	5,772	4,506	713	12,177	899	281	51,209	18,385	3,935	120	315	141	892	.239	.315	.404	.719
21	Cubs	649	708	.478	1,357	.522	45,670	6,372	11,291	2,191	242	1,678	6,083	4,687	664	11,891	838	276	51,585	19,000	4,111	220	344	242	929	.247	.324	.416	.740
22	Cardinals	647	707	.478	1,354	.522	45,466	6,082	11,276	2,187	153	1,579	5,804	4,425	634	11,157	744	234	51,122	18,506	3,919	237	360	181	918	.248	.321	.407	.728
23	Red Sox	629	727	.464	1,356	.536	46,880	6,727	12,192	2,776	192	1,638	6,392	4,404	518	11,524	817	250	52,240	20,266	4,606	93	345	244	1,007	.260	.328	.432	.760
24	Rays	608	748	.448	1,356	.552	45,845	6,169	11,329	2,249	232	1,595	5,854	4,430	605	12,266	1,073	352	51,308	18,827	4,076	97	331	151	862	.247	.320	.411	.730
25	Guardians	606	749	.447	1,355	.553	45,513	6,081	11,216	2,315	189	1,517	5,792	4,294	551	10,382	1,007	264	50,929	18,460	4,021	195	376	250	890	.246	.317	.406	.722