Between the 2000 and 2009 seasons, Andy Pettitte won the most games, with 148 wins.

Interpreted as:

most MLB game regular-season wins by a player from 2000 to 2009

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Andy Pettitte A. Pettitte	148	0	1.000	148	148	2.35	765	8	3	0	1012.0	894	264	296	65	240	16	0	7	4,086	10	6.80	2.13	3.19	0.58	18.7	5.9	1.12	.276	2.63	7.95
2	Randy Johnson R. Johnson	143	0	1.000	143	142	1.92	1,197	23	12	0	1019.1	707	217	244	71	214	44	1	4	3,937	13	10.57	1.89	5.59	0.63	30.4	5.4	0.90	.264	2.15	6.24
3	Jamie Moyer J. Moyer	140	0	1.000	140	138	2.46	571	6	3	0	927.0	762	253	261	88	187	34	1	6	3,688	2	5.54	1.82	3.05	0.85	15.5	5.1	1.02	.240	2.53	7.40
4	Roy Halladay R. Halladay	139	0	1.000	139	139	2.06	780	37	14	0	1063.2	849	243	269	58	140	33	0	2	4,104	15	6.60	1.18	5.57	0.49	19.0	3.4	0.93	.256	2.28	7.18
5	Roy Oswalt R. Oswalt	137	0	1.000	137	134	1.94	824	14	6	0	963.2	763	208	226	62	171	42	0	9	3,775	6	7.70	1.60	4.82	0.58	21.8	4.5	0.97	.262	2.11	7.13
6	Tim Hudson T. Hudson	137	0	1.000	137	137	1.75	670	19	11	0	997.2	749	194	217	53	223	37	0	15	3,875	16	6.04	2.01	3.00	0.48	17.3	5.8	0.97	.241	1.96	6.76
7	CC Sabathia	136	0	1.000	136	136	1.93	845	22	11	0	977.2	722	210	229	54	244	23	0	6	3,796	13	7.78	2.25	3.46	0.50	22.3	6.4	0.99	.254	2.11	6.65
8	Mark Buehrle M. Buehrle	135	0	1.000	135	132	1.88	543	18	8	0	973.1	814	203	234	62	159	17	0	1	3,762	4	5.02	1.47	3.42	0.57	14.4	4.2	1.00	.252	2.16	7.53
9	Mike Mussina M. Mussina	134	0	1.000	134	134	2.12	780	11	9	0	916.1	766	216	231	59	141	15	0	2	3,569	17	7.66	1.38	5.53	0.58	21.9	4.0	0.99	.275	2.27	7.52
10	Greg Maddux G. Maddux	134	0	1.000	134	134	2.08	575	12	7	0	893.2	735	207	223	58	108	18	0	10	3,446	10	5.79	1.09	5.32	0.58	16.7	3.1	0.94	.252	2.25	7.40
11	Barry Zito B. Zito	133	0	1.000	133	133	2.09	711	5	4	0	901.0	647	209	225	57	314	31	0	10	3,595	18	7.10	3.14	2.26	0.57	19.8	8.7	1.07	.238	2.25	6.46
12	Derek Lowe D. Lowe	130	0	1.000	130	121	2.30	502	5	3	0	828.0	641	212	242	50	195	28	9	3	3,262	10	5.46	2.12	2.57	0.54	15.4	6.0	1.01	.238	2.63	6.97
13	Livan Hernandez L. Hernandez	129	0	1.000	129	129	2.45	567	24	7	0	959.0	851	261	278	61	261	26	0	9	3,877	9	5.32	2.45	2.17	0.57	14.6	6.7	1.16	.267	2.61	7.99
14	Javier Vazquez J. Vazquez	128	0	1.000	128	128	2.06	856	15	6	0	919.1	697	210	225	68	195	22	0	7	3,584	15	8.38	1.91	4.39	0.67	23.9	5.4	0.97	.257	2.20	6.82
15	Johan Santana J. Santana	122	0	1.000	122	118	1.71	896	8	6	0	836.2	584	159	173	65	178	16	1	2	3,234	27	9.64	1.91	5.03	0.70	27.7	5.5	0.91	.250	1.86	6.28
16	Tom Glavine T. Glavine	118	0	1.000	118	118	2.08	456	10	7	0	802.1	653	185	199	51	195	13	0	13	3,162	4	5.12	2.19	2.34	0.57	14.4	6.2	1.06	.246	2.23	7.32
17	Jon Garland J. Garland	117	0	1.000	117	115	2.60	400	8	6	0	802.1	695	232	244	66	201	21	0	2	3,199	12	4.49	2.25	1.99	0.74	12.5	6.3	1.12	.250	2.74	7.80
18	Curt Schilling C. Schilling	117	0	1.000	117	113	1.98	878	22	7	0	858.2	656	189	192	77	104	10	4	2	3,277	14	9.20	1.09	8.44	0.81	26.8	3.2	0.89	.262	2.01	6.88
19	Bartolo Colon B. Colon	117	0	1.000	117	117	2.19	665	15	5	0	828.1	658	202	217	63	206	16	0	2	3,281	14	7.23	2.24	3.23	0.68	20.3	6.3	1.04	.255	2.36	7.15
20	Kevin Millwood K. Millwood	115	0	1.000	115	114	2.33	595	10	4	0	789.1	627	204	229	57	185	19	0	12	3,132	16	6.78	2.11	3.22	0.65	19.0	5.9	1.03	.250	2.61	7.15
21	Jeff Suppan J. Suppan	115	0	1.000	115	115	2.67	421	10	4	0	785.2	704	233	246	76	208	33	0	8	3,208	17	4.82	2.38	2.02	0.87	13.1	6.5	1.16	.254	2.82	8.06
22	Pedro Martinez P. Martinez	112	0	1.000	112	112	1.54	895	12	6	0	792.1	501	136	151	43	170	38	0	4	3,021	11	10.17	1.93	5.26	0.49	29.6	5.6	0.85	.244	1.72	5.69
23	Tim Wakefield T. Wakefield	110	0	1.000	110	102	2.62	481	3	0	0	704.0	546	205	227	61	193	35	1	4	2,832	24	6.15	2.47	2.49	0.78	17.0	6.8	1.05	.235	2.90	6.98
24	Roger Clemens R. Clemens	107	0	1.000	107	107	2.18	661	1	1	0	728.0	566	176	186	39	210	24	0	8	2,909	22	8.17	2.60	3.15	0.48	22.7	7.2	1.07	.267	2.30	7.00
25	Josh Beckett J. Beckett	106	0	1.000	106	106	2.17	668	6	4	0	717.2	541	173	185	49	188	27	0	2	2,834	15	8.38	2.36	3.55	0.61	23.6	6.6	1.02	.259	2.32	6.78