Lou Gehrig has the most career games when collecting 4+ RBI, with 100 games.

Interpreted as:

most MLB regular-season games by a player getting at least 4 rbis

	NAME	G	RBI	AB	R	H	2B	3B	HR	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Lou Gehrig L. Gehrig	100	467	430	217	268	52	14	121	78	2	25	5		518	711	187	8				.623	.682	1.653	2.336
2	Babe Ruth B. Ruth	91	404	380	186	228	30	12	125	53	1	30	7		443	657	167	9				.600	.650	1.729	2.379
3	Jimmie Foxx J. Foxx	86	388	359	169	207	28	8	116	53	0	28	6		415	599	152	3			2	.577	.631	1.669	2.300
4	Albert Pujols A. Pujols	79	348	328	148	195	37	0	104	30	5	28	1	0	370	544	141	0	7	6	5	.595	.622	1.659	2.280
5	Alex Rodriguez A. Rodriguez	77	359	334	157	194	28	0	107	33	2	31	9	2	377	543	135	1	7	4	4	.581	.609	1.626	2.235
6	Sammy Sosa S. Sosa	75	339	331	147	198	19	2	110	26	0	42	6	3	362	551	131	0	5	5	2	.598	.619	1.665	2.283
7	Hank Aaron H. Aaron	75	328	335	133	182	21	5	100	18	1	22	2	1	357	513	126	0	3	1	4	.543	.563	1.531	2.094
8	Manny Ramirez M. Ramirez	72	331	283	133	178	29	1	102	33	2	39	0	1	324	515	132	0	6	4	4	.629	.657	1.820	2.477
9	Ted Williams T. Williams	71	325	294	144	173	23	6	95	62	1	15	1	0	357	493	124	0	0	3	4	.588	.661	1.677	2.338
10	Ken Griffey Jr. K. Griffey Jr.	67	291	288	124	157	25	2	88	26	3	36	3	1	325	450	115	0	8	8	0	.545	.572	1.563	2.135
11	David Ortiz D. Ortiz	66	283	292	110	158	29	2	81	26	1	43	0	0	323	434	112	0	4	6	1	.541	.573	1.486	2.059
12	Barry Bonds B. Bonds	65	291	250	129	167	24	1	91	46	0	17	11	1	297	466	116	0	1	13	3	.668	.717	1.864	2.581
13	Hank Greenberg H. Greenberg	65	282	288	129	161	24	5	80	32	0	22	4		320	435	109	0			1	.559	.603	1.510	2.114
14	Al Simmons A. Simmons	65	292	315	112	187	30	11	61	13	2	13	3		333	422	102	3				.594	.612	1.340	1.952
15	Miguel Cabrera M. Cabrera	64	281	285	113	183	39	0	79	20	0	30	1	2	309	459	118	0	4	5	6	.642	.657	1.611	2.267
16	Joe DiMaggio J. DiMaggio	64	301	290	140	175	23	12	83	30	1	5	1	0	322	471	118	1			3	.603	.642	1.624	2.266
17	Juan Gonzalez J. Gonzalez	63	289	281	118	158	22	2	90	16	2	37	1	0	306	454	114	0	7	3	5	.562	.575	1.616	2.191
18	Jeff Kent J. Kent	62	278	262	101	151	43	2	62	28	2	33	2	3	297	384	107	0	5	2	3	.576	.609	1.466	2.075
19	Carlos Delgado C. Delgado	61	273	249	111	145	24	2	88	25	7	30	0	0	289	437	114	0	8	4	0	.582	.612	1.755	2.367
20	Eddie Murray E. Murray	61	270	259	91	142	21	1	64	26	0	19	4	0	293	357	86	0	8	3	5	.548	.573	1.378	1.952
21	Ernie Banks E. Banks	60	263	256	101	143	22	2	78	15	1	11	1	0	281	403	102	0	9	1	3	.559	.566	1.574	2.140
22	Mel Ott M. Ott	60	271	262	125	148	24	4	75	34	2	14	2		301	405	103	3			0	.565	.617	1.546	2.163
23	Willie McCovey W. McCovey	59	253	220	99	123	17	1	76	33	4	21	1	2	262	370	94	0	5	11	2	.559	.611	1.682	2.293
24	Mark Teixeira M. Teixeira	58	260	244	106	134	20	4	84	27	2	35	1	0	276	414	108	0	3	2	2	.549	.591	1.697	2.287
25	Chipper Jones C. Jones	58	250	237	106	147	20	5	68	32	0	16	8	1	276	381	93	0	7	6	5	.620	.649	1.608	2.256