Between the 2007 and 2010 seasons, the New York Yankees had the most wins by a team, with 381 wins.

Interpreted as:

most MLB team regular-season wins from 2007 to 2010

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Yankees	381	267	.588	648	22,516	3,531	6,257	1,215	105	826	3,391	2,497	285	4,156	455	137	25,610	10,160	2,146	136	176	139	555	.278	.355	.451	.806
2	Red Sox	375	273	.579	648	22,374	3,402	6,132	1,398	115	762	3,240	2,581	251	4,370	410	115	25,525	10,046	2,275	106	213	185	560	.274	.353	.449	.802
3	Phillies	371	277	.573	648	22,356	3,283	5,855	1,219	146	817	3,136	2,376	291	4,541	501	93	25,438	9,817	2,182	235	180	258	443	.262	.338	.439	.777
4	Angels	371	277	.573	648	22,204	3,151	6,031	1,167	100	610	2,994	2,001	185	3,994	520	218	24,743	9,228	1,877	149	204	167	539	.272	.334	.416	.750
5	Twins	348	302	.535	650	22,339	3,145	6,092	1,160	166	543	2,981	2,185	168	3,806	367	132	25,094	9,213	1,869	175	227	180	597	.273	.339	.412	.751
6	Rays	343	305	.529	648	22,035	3,161	5,720	1,167	146	726	3,019	2,485	227	5,069	639	206	25,074	9,357	2,039	121	206	130	426	.260	.338	.425	.763
7	Dodgers	341	307	.526	648	22,138	2,882	5,878	1,095	132	531	2,725	2,194	193	4,148	471	191	24,997	8,830	1,758	285	187	236	533	.266	.334	.399	.733
8	Cardinals	341	307	.526	648	22,172	2,970	5,990	1,141	86	625	2,817	2,152	207	3,962	283	137	24,985	9,178	1,852	273	181	261	555	.270	.338	.414	.752
9	Cubs	340	306	.526	646	22,229	2,999	5,894	1,260	105	645	2,858	2,207	199	4,661	284	132	25,035	9,299	2,010	238	162	172	519	.265	.335	.418	.753
10	Rockies	339	310	.522	649	22,176	3,181	5,913	1,193	168	694	3,038	2,437	209	4,912	446	164	25,316	9,524	2,055	305	189	180	473	.267	.342	.429	.772
11	Braves	333	315	.514	648	22,295	3,036	5,946	1,256	105	594	2,901	2,388	194	4,376	243	112	25,328	9,194	1,955	288	163	203	558	.267	.341	.412	.753
12	Rangers	331	317	.511	648	22,444	3,288	6,071	1,238	123	759	3,123	2,081	201	4,670	441	134	25,114	9,832	2,120	187	201	130	472	.270	.335	.438	.773
13	Brewers	330	318	.509	648	22,205	3,086	5,771	1,208	142	793	2,963	2,207	297	4,787	353	133	25,088	9,642	2,143	207	172	183	452	.260	.333	.434	.767
14	Tigers	329	320	.507	649	22,581	3,202	6,139	1,198	158	712	3,072	2,132	202	4,391	307	124	25,239	9,789	2,068	155	169	148	521	.272	.338	.434	.771
15	Blue Jays	329	319	.508	648	22,230	3,020	5,767	1,305	90	757	2,898	2,073	206	4,174	268	92	24,817	9,523	2,152	121	187	114	521	.259	.326	.428	.754
16	White Sox	328	321	.505	649	21,941	2,980	5,676	1,054	74	786	2,857	2,073	256	4,109	418	202	24,582	9,236	1,914	153	159	114	582	.259	.328	.421	.749
17	Mets	326	322	.503	648	22,129	2,930	5,867	1,129	154	572	2,768	2,196	175	4,028	590	170	25,031	9,020	1,855	312	219	237	488	.265	.333	.408	.741
18	Giants	323	325	.498	648	22,062	2,677	5,681	1,137	147	509	2,519	1,863	187	4,208	360	139	24,555	8,639	1,793	267	176	213	554	.258	.318	.392	.710
19	Marlins	322	325	.498	647	22,229	3,051	5,797	1,232	128	720	2,903	2,146	269	5,304	348	123	25,056	9,445	2,080	242	170	184	422	.261	.331	.425	.756
20	Padres	317	332	.488	649	22,039	2,681	5,451	1,087	113	598	2,554	2,199	209	4,853	297	120	24,895	8,558	1,798	276	172	199	479	.247	.319	.388	.708
21	Reds	315	333	.486	648	22,113	2,950	5,711	1,135	102	737	2,822	2,149	237	4,585	371	161	24,988	9,261	1,974	311	178	172	457	.258	.328	.419	.747
22	Indians	311	337	.480	648	22,202	3,035	5,789	1,248	97	638	2,887	2,277	328	4,810	324	134	25,148	9,145	1,983	150	191	154	495	.261	.336	.412	.748
23	Astros	309	338	.478	647	21,944	2,689	5,652	1,099	109	584	2,577	1,859	183	4,109	392	165	24,416	8,721	1,792	275	155	146	541	.258	.319	.397	.716
24	Athletics	307	340	.474	647	22,060	2,809	5,608	1,148	90	540	2,663	2,292	194	4,452	429	127	24,864	8,556	1,778	122	196	84	527	.254	.327	.388	.715
25	Diamondbacks	307	341	.474	648	21,845	2,865	5,479	1,212	166	683	2,747	2,279	182	5,225	355	128	24,707	9,072	2,061	218	183	179	432	.251	.324	.415	.740