Between the 2000 and 2020 seasons, the St. Louis Cardinals had the most wins by an NL team, with 1,842 wins.

Interpreted as:

most nl regular-season wins from 2000 to 2020

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	1,842	1,455	.559	3,297	112,230	15,654	29,739	5,832	517	3,573	14,880	11,034	1,307	22,760	1,514	708	126,817	47,324	9,922	1,312	934	1,028	2,654	.265	.335	.422	.757
2	Dodgers	1,824	1,476	.553	3,300	112,070	14,840	28,940	5,618	582	3,466	14,119	11,087	1,174	23,220	1,907	765	126,380	46,120	9,666	1,216	833	941	2,566	.258	.329	.412	.741
3	Braves	1,770	1,527	.537	3,298	112,682	15,129	29,379	5,868	532	3,470	14,429	11,127	1,035	23,960	1,610	680	126,981	46,721	9,870	1,303	834	971	2,621	.261	.331	.415	.745
4	Giants	1,705	1,592	.517	3,298	112,565	14,396	29,127	5,862	755	3,060	13,689	10,477	983	22,350	1,512	680	126,206	45,679	9,677	1,235	946	1,141	2,632	.259	.325	.406	.731
5	Phillies	1,665	1,634	.505	3,299	112,926	15,059	28,799	5,814	681	3,578	14,342	11,270	1,230	24,601	2,059	577	127,348	46,709	10,073	1,115	807	1,029	2,301	.255	.327	.414	.741
6	Cubs	1,658	1,640	.503	3,299	112,485	14,820	28,768	5,857	589	3,693	14,109	10,780	1,232	25,031	1,481	687	126,524	46,882	10,139	1,228	799	881	2,483	.256	.325	.417	.742
7	Mets	1,634	1,664	.495	3,298	112,198	14,409	28,473	5,679	564	3,380	13,741	10,851	1,171	23,663	2,007	719	126,265	45,420	9,623	1,200	845	967	2,475	.254	.324	.405	.729
8	Diamondbacks	1,623	1,677	.492	3,300	112,824	14,919	28,885	5,978	829	3,476	14,241	10,925	1,033	24,653	1,823	713	126,764	46,949	10,283	1,078	904	934	2,401	.256	.325	.416	.741
9	Nationals	1,616	1,682	.490	3,298	111,649	14,472	28,578	5,852	569	3,336	13,766	10,764	1,122	24,150	1,941	784	125,750	45,576	9,757	1,351	864	956	2,498	.256	.325	.408	.733
10	Brewers	1,594	1,706	.483	3,301	111,804	14,612	28,322	5,751	583	3,804	13,964	10,657	1,365	26,203	2,101	770	125,787	46,651	10,138	1,161	800	831	2,526	.253	.324	.417	.741
11	Reds	1,557	1,743	.472	3,302	112,257	14,678	28,471	5,623	499	3,777	14,014	10,926	1,304	25,323	1,995	792	126,602	46,423	9,899	1,304	811	884	2,363	.254	.325	.414	.738
12	Marlins	1,549	1,747	.470	3,296	112,235	14,072	28,810	5,636	665	3,086	13,346	10,082	1,221	25,034	2,039	814	125,598	45,034	9,387	1,233	827	862	2,464	.257	.323	.401	.724
13	Rockies	1,547	1,755	.469	3,302	113,547	16,339	30,730	6,128	878	3,680	15,539	10,690	986	24,778	1,914	835	127,517	49,654	10,686	1,402	892	887	2,476	.271	.336	.437	.774
14	Padres	1,545	1,756	.468	3,301	111,509	13,706	27,577	5,320	646	3,067	13,015	10,810	988	25,499	2,028	751	125,238	43,390	9,033	1,072	859	751	2,375	.247	.317	.389	.706
15	Pirates	1,492	1,803	.453	3,296	112,088	13,917	28,492	5,725	642	3,025	13,280	9,870	1,400	24,245	1,661	806	125,370	44,576	9,392	1,191	821	800	2,450	.254	.320	.398	.718
16	Astros	1,019	1,086	.484	2,106	71,584	9,457	18,589	3,697	387	2,162	9,006	6,779	805	14,139	1,213	512	80,650	29,546	6,246	928	554	560	1,683	.260	.328	.413	.741