Between the 2000 and 2021 seasons, the St. Louis Cardinals had the most wins by an NL team, with 1,932 wins.

Interpreted as:

most nl regular-season wins from 2000 to 2021

	TEAM	W	L	W%	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cardinals	1,932	1,527	.559	3,459	117,581	16,360	31,042	6,093	539	3,771	15,558	11,512	1,393	24,101	1,603	730	132,816	49,526	10,403	1,352	978	1,060	2,753	.264	.334	.421	.755
2	Dodgers	1,930	1,532	.557	3,462	117,515	15,670	30,270	5,865	606	3,703	14,918	11,700	1,278	24,628	1,972	782	132,619	48,456	10,174	1,248	878	977	2,662	.258	.329	.412	.742
3	Braves	1,858	1,600	.537	3,459	118,045	15,919	30,686	6,137	552	3,709	15,191	11,676	1,102	25,413	1,669	699	133,035	49,054	10,398	1,335	877	1,007	2,702	.260	.330	.416	.746
4	Giants	1,812	1,647	.524	3,460	118,027	15,200	30,487	6,133	780	3,301	14,457	11,079	1,047	23,811	1,578	694	132,400	48,083	10,214	1,271	976	1,186	2,749	.258	.325	.407	.732
5	Phillies	1,747	1,714	.505	3,461	118,292	15,793	30,087	6,076	705	3,776	15,042	11,834	1,297	26,003	2,136	596	133,435	48,901	10,557	1,162	850	1,066	2,404	.254	.327	.413	.740
6	Cubs	1,729	1,731	.500	3,461	117,791	15,525	30,023	6,082	615	3,903	14,781	11,282	1,324	26,627	1,567	724	132,494	49,044	10,600	1,268	829	898	2,616	.255	.325	.416	.741
7	Mets	1,711	1,749	.495	3,460	117,408	15,045	29,716	5,907	582	3,556	14,345	11,346	1,265	25,055	2,061	745	132,121	47,455	10,045	1,234	868	992	2,598	.253	.323	.404	.728
8	Brewers	1,689	1,773	.488	3,463	117,166	15,350	29,573	6,006	601	3,998	14,664	11,243	1,453	27,668	2,183	791	131,883	48,775	10,605	1,186	835	857	2,628	.252	.323	.416	.740
9	Nationals	1,681	1,779	.486	3,460	117,034	15,196	29,966	6,124	589	3,518	14,452	11,337	1,206	25,453	1,997	810	131,861	47,822	10,231	1,389	895	999	2,656	.256	.326	.409	.734
10	Diamondbacks	1,675	1,787	.484	3,462	118,313	15,598	30,182	6,286	860	3,620	14,885	11,462	1,087	26,118	1,866	729	132,904	49,048	10,766	1,110	932	958	2,500	.255	.324	.415	.739
11	Reds	1,640	1,822	.474	3,464	117,680	15,464	29,823	5,918	512	3,999	14,770	11,479	1,409	26,748	2,031	816	132,763	48,762	10,429	1,339	856	906	2,492	.253	.325	.414	.739
12	Padres	1,624	1,839	.469	3,463	116,893	14,435	28,882	5,593	667	3,247	13,710	11,396	1,049	26,823	2,138	790	131,351	45,550	9,507	1,108	905	793	2,496	.247	.317	.390	.707
13	Rockies	1,621	1,842	.468	3,463	118,921	17,078	32,068	6,403	912	3,862	16,248	11,181	1,044	26,134	1,990	858	133,524	51,881	11,177	1,450	928	911	2,574	.270	.335	.436	.772
14	Marlins	1,616	1,842	.467	3,458	117,583	14,695	30,054	5,862	688	3,244	13,940	10,532	1,286	26,587	2,145	843	131,521	47,024	9,794	1,263	857	887	2,559	.256	.321	.400	.721
15	Pirates	1,553	1,904	.449	3,458	117,424	14,526	29,753	5,965	677	3,149	13,850	10,399	1,449	25,573	1,721	836	131,352	46,519	9,791	1,222	858	824	2,552	.253	.320	.396	.716
16	Astros	1,019	1,086	.484	2,106	71,584	9,457	18,589	3,697	387	2,162	9,006	6,779	805	14,139	1,213	512	80,650	29,546	6,246	928	554	560	1,683	.260	.328	.413	.741