Walter Johnson has made the most career plate appearances by a starting pitcher, with 2,220 plate appearances.

	NAME	PA	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Walter Johnson W. Johnson	2,220	666	2,045	209	481	86	37	22		95	10		12		707	145	70				.235	.273	.346	.618
2	Warren Spahn W. Spahn	2,008	665	1,825	137	357	57	6	33	183	95	7	479	4	1	525	96	67	14	0	22	.196	.236	.288	.524
3	Grover Alexander G. Alexander	1,918	600	1,751	149	368	58	13	11		75	2	262	3		485	82	90				.210	.243	.277	.520
4	Steve Carlton S. Carlton	1,874	677	1,717	120	346	49	6	13	140	40	10	411	2	2	446	68	94	13	0	34	.202	.222	.260	.482
5	Greg Maddux G. Maddux	1,805	718	1,587	100	271	35	2	5	84	34	5	418	11	2	325	42	177	2	0	15	.171	.190	.205	.395
6	Christy Mathewson C. Mathewson	1,780	551	1,591	141	337	43	12	7		112	15		21		425	62	62				.212	.270	.267	.537
7	Early Wynn E. Wynn	1,748	611	1,572	127	339	53	4	15	150	120	2	298	1	0	445	72	50	4	0	32	.216	.271	.283	.555
8	Red Ruffing R. Ruffing	1,748	538	1,631	190	442	84	11	32	217	74	6	211	1		644	127	37			11	.271	.305	.395	.700
9	Robin Roberts R. Roberts	1,747	609	1,492	105	252	55	9	5	103	132	8	358	3	1	340	69	109	6	0	31	.169	.239	.228	.467
10	Phil Niekro P. Niekro	1,666	595	1,503	79	257	40	1	7	109	16	12	298	0	1	320	48	123	12	0	35	.171	.185	.213	.398
11	Eddie Plank E. Plank	1,665	529	1,507	122	312	35	6	3		63	24		12		368	44	71				.207	.250	.244	.495
12	Tom Glavine T. Glavine	1,629	661	1,310	90	244	25	2	1	90	99	2	326	1	0	276	28	215	3	0	13	.186	.244	.211	.455
13	Ted Lyons T. Lyons	1,605	484	1,452	134	340	46	9	5	137	65	6	183	0		419	60	82			9	.234	.270	.289	.558
14	Eppa Rixey E. Rixey	1,580	554	1,440	92	280	33	4	3		49	9	206	2		330	40	82				.194	.226	.229	.455
15	Burleigh Grimes B. Grimes	1,574	496	1,434	144	358	58	11	2	159	67	4	217	15		444	71	69				.250	.285	.310	.595
16	Don Sutton D. Sutton	1,554	583	1,349	58	193	15	1	0	63	60	6	364	1	0	210	16	136	3	0	29	.143	.183	.156	.338
17	Tom Seaver T. Seaver	1,548	554	1,312	95	202	28	5	12	86	108	4	484	4	0	276	45	120	4	0	22	.154	.220	.210	.430
18	Lefty Grove L. Grove	1,460	457	1,261	112	189	21	5	14	113	99	2	549	1		262	40	98			1	.150	.213	.208	.421
19	Bob Feller B. Feller	1,459	484	1,263	98	190	28	13	8	98	95	3	499	1	1	268	49	98	0	0	15	.150	.212	.212	.424
20	Bob Gibson B. Gibson	1,452	482	1,298	118	269	43	5	24	140	59	8	403	13	10	394	72	70	17	0	13	.207	.243	.304	.547
21	George Mullin G. Mullin	1,442	425	1,306	147	354	63	22	3		113	7		17		470	88	20				.271		.360
22	Red Faber R. Faber	1,423	483	1,166	98	159	20	2	3		155	6	438	7		192	25	96				.136	.241	.165	.406
23	Earl Whitehill E. Whitehill	1,412	473	1,260	102	256	23	7	4	97	97	1	207	3		305	34	54			1	.203	.261	.242	.503
24	Sad Sam Jones S. Sam Jones	1,391	488	1,156	129	227	43	5	4		135	23	321	5		292	52	77				.196	.293	.253	.546
25	Bobo Newsom B. Newsom	1,381	483	1,281	79	242	27	3	1	97	16	1	254	1	0	278	31	83			28	.189	.200	.217	.417