Between the 1898 and 1907 seasons, Rube Waddell fanned the most batters, with 1,922 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rube Waddell R. Waddell	1,922	321	160	113	.586	273	2.15	219	40	1	2408.1	1,985	575	867	35	639	98	38	9,541	64	7.18	2.39	3.01	0.13	20.1	6.7	1.09	.285	3.24	71	2.09	70	7.42	230.6
2	Cy Young C. Young	1,518	422	241	149	.618	382	2.27	357	44	8	3497.2	3,209	883	1,288	56	383	74	37	13,597	53	3.91	0.99	3.96	0.14	11.2	2.8	1.03	.273	3.31	72	2.38	75	8.26	311.3
3	Vic Willis V. Willis	1,392	400	195	171	.533	375	2.67	327	38	7	3189.2	2,915	946	1,328	55	999	145	24	13,049	83	3.93	2.82	1.39	0.16	10.7	7.7	1.23	.273	3.75	85	3.06	94	8.22	73.9
4	Christy Mathewson C. Mathewson	1,391	296	174	95	.647	268	2.17	222	42	9	2308.2	1,962	557	810	30	566	47	26	9,220	84	5.42	2.21	2.46	0.12	15.1	6.1	1.10	.269	3.16	75	2.32	78	7.65	164.8
5	Jack Powell J. Powell	1,222	400	178	168	.514	359	3.10	312	31	10	3096.2	3,052	1,065	1,436	94	746	90	39	12,679	54	3.55	2.17	1.64	0.27	9.6	5.9	1.23	.281	4.17	97	3.07	98	8.87	22.9
6	Bill Donovan B. Donovan	1,123	267	130	106	.551	237	2.74	216	21	6	2156.0	1,910	656	906	19	807	66	29	8,894	57	4.69	3.37	1.39	0.08	12.6	9.1	1.26	.275	3.78	94	2.88	100	7.97	5.4
7	Jack Chesbro J. Chesbro	1,121	337	184	107	.632	296	2.58	238	32	4	2552.1	2,294	732	1,021	30	606	96	35	10,227	51	3.95	2.14	1.85	0.11	11.0	5.9	1.14	.270	3.60	84	2.70	88	8.09	100.3
8	Eddie Plank E. Plank	1,075	266	153	95	.617	253	2.53	218	29	0	2156.0	1,943	605	810	24	491	123	11	8,661	46	4.49	2.05	2.19	0.10	12.4	5.7	1.13	.276	3.38	84	2.54	87	8.11	97.8
9	Bill Dinneen B. Dinneen	1,062	347	150	163	.479	323	3.05	287	19	7	2795.2	2,712	947	1,306	73	747	71	22	11,466	65	3.42	2.40	1.42	0.24	9.3	6.5	1.24	.277	4.20	95	3.12	98	8.73	28.7
10	Joe McGinnity J. McGinnity	1,013	428	235	135	.635	361	2.68	307	27	19	3255.1	3,084	969	1,363	44	775	172	59	13,370	27	2.80	2.14	1.31	0.12	7.6	5.8	1.19	.267	3.77	84	3.06	94	8.53	74.8
11	Noodles Hahn N. Hahn	917	243	130	94	.580	231	2.55	212	25	0	2029.1	1,916	574	821	27	381	52	11	8,126	28	4.07	1.69	2.41	0.12	11.3	4.7	1.13	.280	3.64	75	2.65	77	8.50	181.2
12	Doc White D. White	902	244	125	93	.573	220	2.18	177	30	2	1841.1	1,611	447	656	22	399	70	22	7,292	38	4.41	1.95	2.26	0.11	12.4	5.5	1.09	.269	3.21	81	2.49	94	7.87	24.3
13	Tom Hughes T. Hughes	873	233	82	113	.421	204	3.14	164	17	4	1698.2	1,692	593	837	27	527	66	27	7,096	49	4.63	2.79	1.66	0.14	12.3	7.4	1.31	.297	4.43	110	2.79	100	8.96	1.6
14	Jesse Tannehill J. Tannehill	872	318	184	102	.643	291	2.62	245	32	5	2486.1	2,479	725	1,019	37	404	114	26	10,058	22	3.16	1.46	2.16	0.13	8.7	4.0	1.16	.283	3.69	84	2.79	90	8.97	94.8
15	Chick Fraser C. Fraser	870	328	137	157	.466	299	3.56	263	20	3	2554.2	2,589	1,011	1,420	45	968	162	29	10,962	90	3.06	3.41	0.90	0.16	7.9	8.8	1.39	.285	5.00	111	3.53	109	9.12	-81.5
16	Deacon Phillippe D. Phillippe	857	311	167	104	.616	268	2.56	230	25	8	2335.2	2,261	664	964	35	335	52	42	9,325	41	3.30	1.29	2.56	0.13	9.2	3.6	1.11	.277	3.71	82	2.62	82	8.71	146.2
17	Harry Howell H. Howell	852	288	112	127	.469	247	2.84	217	18	5	2202.2	2,107	696	1,027	26	597	77	39	9,020	42	3.48	2.44	1.43	0.11	9.4	6.6	1.23	.279	4.20	91	2.88	96	8.61	31.1
18	George Mullin G. Mullin	846	251	111	113	.496	233	2.66	203	21	5	1998.0	1,875	590	878	17	684	63	17	8,260	50	3.81	3.08	1.24	0.08	10.2	8.3	1.28	.279	3.95	94	2.86	104	8.45	-21.6
19	Togie Pittinger T. Pittinger	832	262	115	113	.504	227	3.10	187	23	3	2040.2	2,017	702	985	39	734	96	30	8,579	43	3.67	3.24	1.13	0.17	9.7	8.6	1.35	.288	4.34	103	3.27	107	8.90	-43.6
20	Al Orth A. Orth	813	346	165	146	.531	309	3.13	259	28	5	2646.0	2,728	920	1,266	49	480	68	36	10,776	34	2.77	1.63	1.69	0.17	7.5	4.5	1.21	.286	4.31	99	2.87	92	9.28	83.4
21	Sam Leever S. Leever	763	305	165	87	.655	267	2.48	221	35	7	2287.0	2,092	630	888	26	507	72	35	9,177	43	3.00	2.00	1.50	0.10	8.3	5.5	1.14	.265	3.49	79	2.88	91	8.23	73.1
22	Casey Patten C. Patten	751	265	106	125	.459	234	3.34	205	17	4	2041.1	2,121	758	1,060	40	550	74	27	8,525	27	3.31	2.42	1.37	0.18	8.8	6.5	1.31	.293	4.67	115	2.98	105	9.35	-26.3
23	Frank Kitson F. Kitson	731	304	129	118	.522	250	3.18	211	19	7	2221.2	2,331	784	1,087	52	491	81	50	9,212	38	2.96	1.99	1.49	0.21	7.9	5.3	1.27	.290	4.40	103	3.11	100	9.44	9.6
24	Dummy Taylor D. Taylor	717	247	108	101	.517	222	2.78	154	20	1	1788.2	1,750	552	814	33	517	68	21	7,413	43	3.61	2.60	1.39	0.17	9.7	7.0	1.27	.282	4.10	93	3.01	100	8.81	-2.6
25	Bob Ewing B. Ewing	703	184	80	76	.513	167	2.39	147	9	1	1508.1	1,389	400	606	18	393	37	17	6,036	32	4.19	2.34	1.79	0.11	11.6	6.5	1.18	.281	3.62	80	2.53	83	8.29	95.1