Between the 1899 and 1908 seasons, Rube Waddell fanned the most hitters, with 2,154 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rube Waddell R. Waddell	2,154	364	179	127	.585	309	2.12	244	45	4	2694.0	2,208	635	960	35	729	106	44	10,684	71	7.20	2.44	2.95	0.12	20.2	6.8	1.09	.284	3.21	73	2.03	70	7.38	251.3
2	Christy Mathewson C. Mathewson	1,650	352	211	106	.666	312	2.06	256	53	14	2699.1	2,243	619	895	35	608	50	35	10,689	86	5.50	2.03	2.71	0.12	15.4	5.7	1.06	.265	2.98	73	2.17	74	7.48	217.2
3	Cy Young C. Young	1,567	412	237	147	.617	374	2.16	347	46	10	3419.0	3,052	819	1,189	51	379	66	35	13,193	48	4.12	1.00	4.13	0.13	11.9	2.9	1.00	.270	3.13	70	2.25	73	8.03	304.5
4	Vic Willis V. Willis	1,329	400	193	169	.533	375	2.60	323	44	7	3183.1	2,890	918	1,280	52	920	122	25	12,913	78	3.76	2.60	1.44	0.15	10.3	7.1	1.20	.271	3.62	86	2.93	94	8.17	72.5
5	Jack Chesbro J. Chesbro	1,245	382	198	127	.609	327	2.62	258	35	5	2841.0	2,570	826	1,155	36	673	110	48	11,388	62	3.94	2.13	1.85	0.11	10.9	5.9	1.14	.272	3.66	87	2.66	89	8.14	103.7
6	Bill Donovan B. Donovan	1,228	279	147	107	.579	258	2.61	235	27	6	2310.2	2,032	670	910	21	791	65	20	9,445	48	4.78	3.08	1.55	0.08	13.0	8.4	1.22	.274	3.54	92	2.70	97	7.91	29.4
7	Jack Powell J. Powell	1,214	391	171	166	.507	350	3.02	299	30	11	3010.2	2,932	1,011	1,355	87	681	80	39	12,196	48	3.63	2.04	1.78	0.26	10.0	5.6	1.20	.281	4.05	98	2.92	97	8.76	25.6
8	Eddie Plank E. Plank	1,210	300	167	111	.601	281	2.49	239	33	1	2400.2	2,145	664	881	25	537	132	16	9,617	53	4.54	2.01	2.25	0.09	12.6	5.6	1.12	.275	3.30	85	2.46	86	8.04	113.2
9	Joe McGinnity J. McGinnity	1,068	465	246	142	.634	381	2.66	314	32	24	3441.1	3,276	1,016	1,436	52	812	179	73	14,132	30	2.79	2.12	1.32	0.14	7.6	5.7	1.19	.268	3.76	85	3.04	95	8.57	68.9
10	Tom Hughes T. Hughes	1,038	276	100	128	.439	235	3.01	188	20	8	1975.0	1,916	661	928	30	604	72	38	8,167	62	4.73	2.75	1.72	0.14	12.7	7.4	1.28	.294	4.23	108	2.68	99	8.73	6.7
11	Doc White D. White	1,028	285	143	106	.574	257	2.24	201	35	2	2137.1	1,873	531	750	25	468	79	24	8,461	44	4.33	1.97	2.20	0.11	12.1	5.5	1.10	.269	3.16	86	2.45	95	7.89	19.8
12	Bill Dinneen B. Dinneen	1,018	345	155	154	.502	312	2.92	276	21	7	2744.1	2,607	889	1,218	69	712	59	30	11,131	55	3.34	2.33	1.43	0.23	9.1	6.4	1.21	.274	3.99	94	3.05	100	8.55	19.2
13	George Mullin G. Mullin	967	290	128	126	.504	263	2.71	229	22	5	2288.2	2,176	690	1,020	18	755	70	25	9,447	62	3.80	2.97	1.28	0.07	10.2	8.0	1.28	.283	4.01	98	2.76	103	8.56	-13.8
14	Harry Howell H. Howell	967	327	128	145	.469	277	2.70	242	20	6	2509.0	2,371	754	1,119	27	656	93	46	10,192	46	3.47	2.35	1.47	0.10	9.5	6.4	1.21	.277	4.01	90	2.78	97	8.50	29.7
15	Noodles Hahn N. Hahn	917	243	130	94	.580	231	2.55	212	25	0	2029.1	1,916	574	821	27	381	52	11	8,126	28	4.07	1.69	2.41	0.12	11.3	4.7	1.13	.280	3.64	75	2.65	77	8.50	181.2
16	Chick Fraser C. Fraser	859	322	139	146	.488	284	3.30	248	21	5	2472.1	2,451	906	1,300	43	917	139	36	10,484	89	3.13	3.34	0.94	0.16	8.2	8.7	1.36	.282	4.73	107	3.42	109	8.92	-70.8
17	Deacon Phillippe D. Phillippe	858	316	167	104	.616	268	2.60	230	25	8	2347.2	2,281	679	979	35	338	52	44	9,384	43	3.29	1.30	2.54	0.13	9.1	3.6	1.12	.277	3.75	84	2.62	82	8.74	145.9
18	Togie Pittinger T. Pittinger	832	262	115	113	.504	227	3.10	187	23	3	2040.2	2,017	702	985	39	734	96	30	8,579	43	3.67	3.24	1.13	0.17	9.7	8.6	1.35	.288	4.34	103	3.27	107	8.90	-43.6
19	Addie Joss A. Joss	804	240	141	79	.641	220	1.89	201	40	5	1977.0	1,594	415	624	17	315	52	17	7,567	25	3.66	1.43	2.55	0.08	10.6	4.2	0.97	.247	2.84	69	2.27	86	7.26	76.2
20	Bob Ewing B. Ewing	798	221	97	91	.516	199	2.36	170	13	4	1802.0	1,636	472	711	23	450	42	22	7,124	39	3.99	2.25	1.77	0.11	11.2	6.3	1.16	.278	3.55	82	2.49	84	8.17	103.2
21	Jesse Tannehill J. Tannehill	795	286	161	93	.634	263	2.62	216	27	3	2236.1	2,222	650	910	35	367	108	23	9,037	18	3.20	1.48	2.17	0.14	8.8	4.1	1.16	.283	3.66	87	2.77	92	8.94	69.5
22	Al Orth A. Orth	783	335	152	146	.510	298	3.16	242	28	5	2535.1	2,572	889	1,197	51	457	64	35	10,268	35	2.78	1.62	1.71	0.18	7.6	4.5	1.19	.283	4.25	102	2.84	93	9.13	68.4
23	Sam Leever S. Leever	776	338	179	94	.656	284	2.45	233	39	9	2446.2	2,245	666	938	27	543	77	47	9,817	46	2.85	2.00	1.43	0.10	7.9	5.5	1.14	.264	3.45	80	2.86	92	8.26	66.7
24	Ed Walsh E. Walsh	774	203	95	52	.646	147	1.73	118	28	13	1412.0	1,110	271	412	7	262	30	51	5,411	47	4.93	1.67	2.95	0.04	14.3	4.8	0.97	.254	2.63	72	1.83	80	7.08	64.1
25	Chief Bender C. Bender	774	187	84	63	.571	144	2.58	123	16	7	1299.0	1,113	373	521	19	317	54	40	5,150	33	5.36	2.20	2.44	0.13	15.0	6.2	1.10	.274	3.61	95	2.28	85	7.71	56