Between the 1903 and 1912 seasons, Christy Mathewson fanned the most hitters, with 1,858 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Christy Mathewson C. Mathewson	1,858	434	278	109	.718	379	1.90	298	55	24	3255.2	2,770	686	980	45	582	29	49	12,740	62	5.14	1.61	3.19	0.12	14.6	4.6	1.03	.266	2.71	67	2.05	69	7.66	321.6
2	Rube Waddell R. Waddell	1,755	302	140	104	.574	251	2.01	183	44	4	2132.0	1,725	477	698	18	589	73	39	8,363	51	7.41	2.49	2.98	0.08	21.0	7.0	1.09	.288	2.95	76	1.78	69	7.28	189.5
3	Ed Walsh E. Walsh	1,668	397	182	118	.607	289	1.77	236	54	34	2773.2	2,177	544	801	22	539	46	100	10,622	67	5.41	1.75	3.09	0.07	15.7	5.1	0.98	.258	2.60	67	1.94	77	7.06	171.6
4	Eddie Plank E. Plank	1,527	380	214	117	.647	342	2.16	273	46	9	2872.0	2,476	690	946	24	685	143	32	11,362	55	4.79	2.15	2.23	0.08	13.4	6.0	1.10	.273	2.96	79	2.36	88	7.76	98.5
5	Chief Bender C. Bender	1,294	309	155	89	.635	244	2.33	200	27	13	2186.1	1,858	567	781	24	500	74	59	8,547	59	5.33	2.06	2.59	0.10	15.1	5.9	1.08	.276	3.21	85	2.20	81	7.65	116.2
6	George Mullin G. Mullin	1,286	393	195	157	.554	358	2.69	307	34	6	3081.2	2,871	920	1,297	32	993	106	33	12,557	66	3.76	2.90	1.30	0.09	10.2	7.9	1.25	.280	3.79	97	2.80	103	8.38	-25.9
7	Cy Young C. Young	1,245	313	160	125	.561	285	2.18	252	36	9	2556.1	2,226	620	871	32	323	53	25	9,771	49	4.38	1.14	3.85	0.11	12.7	3.3	1.00	.270	3.07	81	2.02	77	7.84	172.7
8	Walter Johnson W. Johnson	1,218	225	115	90	.561	194	1.69	169	33	6	1724.1	1,354	324	522	13	379	65	30	6,722	78	6.36	1.98	3.21	0.07	18.1	5.6	1.01	.266	2.72	63	1.92	72	7.07	145.6
9	Red Ames R. Ames	1,139	274	106	76	.582	207	2.45	126	15	11	1761.0	1,507	480	715	17	612	38	46	7,119	104	5.82	3.13	1.86	0.09	16.0	8.6	1.20	.280	3.65	87	2.36	81	7.70	109.5
10	Mordecai Brown M. Brown	1,105	360	195	96	.670	261	1.82	223	49	39	2481.2	2,058	502	757	26	495	46	93	9,618	45	4.01	1.80	2.23	0.09	11.5	5.1	1.03	.256	2.75	64	2.30	80	7.46	153.5
11	Earl Moore E. Moore	1,088	266	117	103	.532	228	2.50	159	24	2	1956.2	1,668	543	779	36	749	80	27	8,008	48	5.00	3.45	1.45	0.17	13.6	9.4	1.24	.270	3.58	86	2.91	99	7.67	9.9
12	Bill Donovan B. Donovan	1,078	259	139	96	.591	241	2.49	213	29	3	2131.1	1,857	590	801	27	684	64	18	8,626	38	4.55	2.89	1.58	0.11	12.5	7.9	1.19	.270	3.38	91	2.62	98	7.84	15.5
13	Jack Powell J. Powell	1,033	336	126	158	.444	293	2.59	225	28	10	2494.2	2,317	719	1,017	50	542	56	38	9,943	39	3.73	1.96	1.91	0.18	10.4	5.5	1.15	.274	3.67	94	2.60	98	8.36	15.1
14	Doc White D. White	1,028	341	157	119	.569	293	2.25	204	42	4	2395.1	2,114	598	814	26	503	88	41	9,451	47	3.86	1.89	2.04	0.10	10.9	5.3	1.09	.267	3.06	87	2.46	97	7.94	0.6
15	Nap Rucker N. Rucker	1,019	251	102	108	.486	206	2.32	157	33	10	1851.2	1,572	477	611	33	572	61	43	7,276	36	4.95	2.78	1.78	0.16	14.0	7.9	1.16	.275	2.97	85	2.56	90	7.64	54.8
16	Tom Hughes T. Hughes	1,012	301	107	130	.451	242	2.93	172	23	9	2027.1	1,970	659	943	40	614	66	52	8,346	53	4.49	2.73	1.65	0.18	12.1	7.4	1.27	.292	4.19	108	2.73	102	8.75	-19.6
17	Vic Willis V. Willis	960	310	140	130	.519	285	2.57	224	32	6	2391.0	2,188	684	941	32	662	60	25	9,605	48	3.61	2.49	1.45	0.12	10.0	6.9	1.19	.273	3.54	94	2.64	94	8.24	39.6
18	Bob Ewing B. Ewing	954	276	119	112	.515	252	2.47	195	19	4	2183.1	1,971	598	873	30	567	52	24	8,647	42	3.93	2.34	1.68	0.12	11.0	6.6	1.16	.276	3.60	86	2.51	86	8.12	107.6
19	Jack Chesbro J. Chesbro	916	270	128	94	.577	228	2.59	168	18	2	1958.0	1,759	563	799	27	438	55	36	7,757	42	4.21	2.01	2.09	0.12	11.8	5.6	1.12	.274	3.67	92	2.40	87	8.09	89.9
20	Frank Smith F. Smith	907	283	120	97	.553	219	2.44	169	25	4	1947.2	1,618	529	721	12	580	41	56	7,689	61	4.19	2.68	1.56	0.06	11.8	7.5	1.13	.261	3.33	96	2.44	100	7.48	-11.2
21	Orval Overall O. Overall	905	207	104	66	.612	173	2.18	127	29	12	1467.1	1,159	356	487	15	525	44	30	5,849	57	5.55	3.22	1.72	0.09	15.5	9.0	1.15	.262	2.99	79	2.35	84	7.11	71.9
22	Hooks Wiltse H. Wiltse	904	302	135	84	.616	220	2.50	151	27	24	1957.1	1,749	543	720	50	471	37	70	7,791	38	4.16	2.17	1.92	0.23	11.6	6.0	1.13	.268	3.31	90	2.56	90	8.04	64
23	Jack Coombs J. Coombs	869	234	115	66	.635	187	2.56	135	28	8	1616.1	1,374	460	609	17	597	58	38	6,514	45	4.84	3.32	1.46	0.09	13.3	9.2	1.22	.273	3.39	91	2.74	102	7.65	-11.8
24	Addie Joss A. Joss	814	254	143	84	.630	231	1.77	206	40	5	2057.2	1,663	405	610	17	289	45	20	7,815	23	3.56	1.26	2.82	0.07	10.4	3.7	0.95	.248	2.67	68	2.16	86	7.27	77.2
25	Ed Reulbach E. Reulbach	789	271	135	62	.685	213	2.19	148	31	9	1826.0	1,418	445	579	20	629	84	50	7,231	28	3.89	3.10	1.25	0.10	10.9	8.7	1.12	.245	2.85	77	2.85	99	6.99	4.1