Between the 1905 and 1914 seasons, Walter Johnson struck out the most hitters, with 1,686 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Walter Johnson W. Johnson	1,686	324	179	115	.609	270	1.62	231	53	9	2442.0	1,873	439	666	25	491	85	49	9,399	94	6.21	1.81	3.43	0.09	17.9	5.2	0.97	.260	2.45	60	1.93	71	6.90	221.4
2	Ed Walsh E. Walsh	1,660	403	186	121	.606	300	1.78	240	55	34	2805.1	2,211	554	812	22	566	48	93	10,775	70	5.33	1.82	2.93	0.07	15.4	5.3	0.99	.258	2.61	67	1.99	78	7.09	166.9
3	Christy Mathewson C. Mathewson	1,552	422	264	108	.710	361	1.96	282	57	25	3139.2	2,748	685	951	58	448	17	55	12,247	44	4.45	1.28	3.46	0.17	12.7	3.7	1.02	.264	2.73	70	2.12	72	7.88	278.6
4	Eddie Plank E. Plank	1,411	368	198	101	.662	311	2.22	233	47	16	2606.2	2,237	644	862	22	633	112	47	10,220	50	4.87	2.19	2.23	0.08	13.8	6.2	1.10	.275	2.98	82	2.31	86	7.72	102.2
5	Red Ames R. Ames	1,270	342	128	107	.545	258	2.53	145	18	17	2158.0	1,902	606	887	29	738	47	60	8,790	122	5.30	3.08	1.72	0.12	14.4	8.4	1.22	.279	3.70	88	2.53	85	7.93	104.4
6	Chief Bender C. Bender	1,260	320	166	77	.683	235	2.17	181	30	28	2128.1	1,819	513	703	23	490	49	77	8,302	57	5.33	2.07	2.57	0.10	15.2	5.9	1.08	.277	2.97	80	2.15	79	7.69	124.8
7	Nap Rucker N. Rucker	1,165	308	123	129	.488	255	2.43	178	37	13	2215.1	1,921	599	767	38	666	70	50	8,771	40	4.73	2.71	1.75	0.15	13.3	7.6	1.17	.276	3.12	87	2.59	89	7.80	71.3
8	Rube Waddell R. Waddell	1,104	217	94	69	.577	167	2.02	110	32	4	1425.0	1,144	320	480	10	413	51	38	5,576	34	6.97	2.61	2.67	0.06	19.8	7.4	1.09	.284	3.03	80	1.81	73	7.23	106
9	Mordecai Brown M. Brown	1,095	382	196	96	.671	256	1.99	212	47	44	2474.1	2,081	547	763	33	491	38	117	9,601	42	3.98	1.79	2.23	0.12	11.4	5.1	1.04	.258	2.78	68	2.32	80	7.57	155.8
10	George Mullin G. Mullin	1,059	361	177	140	.558	314	2.83	252	22	6	2691.1	2,566	847	1,177	33	890	105	41	11,033	57	3.54	2.98	1.19	0.11	9.6	8.1	1.28	.283	3.94	101	2.88	105	8.58	-32.5
11	Cy Falkenberg C. Falkenberg	1,009	273	115	98	.540	224	2.60	154	26	7	1918.1	1,733	554	774	15	573	56	37	7,711	82	4.73	2.69	1.76	0.07	13.1	7.4	1.20	.284	3.63	95	2.41	90	8.13	64.4
12	Ed Reulbach E. Reulbach	964	340	154	89	.634	257	2.28	171	36	12	2230.2	1,764	564	748	29	767	99	68	8,907	37	3.89	3.09	1.26	0.12	10.8	8.6	1.13	.246	3.02	80	2.88	99	7.12	6.6
13	Orval Overall O. Overall	935	218	108	71	.603	182	2.26	133	30	12	1535.1	1,232	385	520	16	551	45	30	6,145	57	5.48	3.23	1.70	0.09	15.2	9.0	1.16	.264	3.05	81	2.39	85	7.22	72.4
14	Earl Moore E. Moore	933	266	98	103	.488	211	2.94	124	22	5	1756.1	1,554	574	773	43	777	76	40	7,320	37	4.78	3.98	1.20	0.22	12.7	10.6	1.33	.275	3.96	97	3.19	106	7.96	-28.2
15	Joe Wood J. Wood	923	193	102	51	.667	141	2.05	111	25	6	1258.2	997	287	453	9	368	48	43	4,964	40	6.60	2.63	2.51	0.06	18.6	7.4	1.08	.273	3.24	70	2.20	76	7.13	100.6
16	Howie Camnitz H. Camnitz	888	312	132	102	.564	233	2.70	135	20	15	2016.1	1,785	604	807	40	625	62	65	8,133	33	3.96	2.79	1.42	0.18	10.9	7.7	1.20	.268	3.60	90	2.84	96	7.97	24
17	Frank Smith F. Smith	883	296	114	96	.543	218	2.53	156	22	6	1919.0	1,641	540	745	20	569	29	63	7,629	54	4.14	2.67	1.55	0.09	11.6	7.5	1.15	.265	3.49	97	2.49	99	7.70	-5.7
18	Jack Coombs J. Coombs	870	238	115	67	.632	191	2.60	135	28	8	1629.2	1,387	470	622	17	606	60	38	6,571	45	4.80	3.35	1.44	0.09	13.2	9.2	1.22	.273	3.44	92	2.75	102	7.66	-14.9
19	Cy Young C. Young	869	230	106	100	.515	209	2.25	178	19	6	1834.2	1,605	458	652	20	257	40	18	7,022	40	4.26	1.26	3.38	0.10	12.4	3.7	1.01	.272	3.20	84	2.00	77	7.87	119.4
20	Bob Groom B. Groom	866	237	85	109	.438	203	3.07	127	13	4	1634.0	1,568	558	771	39	499	44	23	6,656	51	4.77	2.75	1.74	0.21	13.0	7.5	1.26	.294	4.25	105	2.78	98	8.64	15.9
21	Hooks Wiltse H. Wiltse	843	315	123	82	.600	206	2.45	137	25	25	1888.1	1,693	513	699	45	430	33	92	7,497	36	4.02	2.05	1.96	0.21	11.2	5.7	1.12	.268	3.33	88	2.52	88	8.07	70.4
22	Doc White D. White	838	293	126	95	.570	235	2.38	154	32	4	1970.1	1,761	522	669	18	405	70	47	7,752	38	3.83	1.85	2.07	0.08	10.8	5.2	1.10	.271	3.06	92	2.39	94	8.04	17.7
23	Tom Hughes T. Hughes	836	269	81	112	.420	191	2.98	125	17	15	1651.2	1,593	547	790	34	533	61	65	6,804	49	4.56	2.90	1.57	0.19	12.3	7.8	1.29	.292	4.30	110	2.78	103	8.68	-25.9
24	Rube Marquard R. Marquard	818	212	94	68	.580	168	2.74	89	14	10	1377.0	1,242	419	548	41	397	26	27	5,584	46	5.35	2.59	2.06	0.27	14.6	7.1	1.19	.279	3.58	91	2.70	87	8.12	63.3
25	Grover Alexander G. Alexander	795	187	96	53	.644	146	2.63	111	25	9	1338.2	1,189	391	505	33	385	28	37	5,423	13	5.34	2.59	2.06	0.22	14.7	7.1	1.18	.276	3.40	80	2.71	80	7.99	101.8