Between the 1906 and 1915 seasons, Walter Johnson struck out the most hitters, with 1,889 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Walter Johnson W. Johnson	1,889	371	206	128	.617	309	1.61	266	60	13	2778.2	2,131	497	749	26	547	104	57	10,679	101	6.12	1.77	3.45	0.08	17.7	5.1	0.96	.259	2.43	59	1.93	70	6.90	259.8
2	Ed Walsh E. Walsh	1,601	384	181	118	.605	290	1.75	234	55	34	2695.2	2,109	525	763	22	544	45	86	10,338	63	5.35	1.82	2.94	0.07	15.5	5.3	0.98	.257	2.55	66	1.98	77	7.04	163.4
3	Christy Mathewson C. Mathewson	1,403	406	241	113	.681	348	2.14	261	50	22	2987.0	2,695	711	963	63	404	17	50	11,721	39	4.23	1.22	3.47	0.19	12.0	3.4	1.04	.268	2.90	77	2.17	74	8.12	241.2
4	Eddie Plank E. Plank	1,348	369	195	100	.661	301	2.20	221	49	19	2528.1	2,162	619	824	20	612	91	57	9,886	45	4.80	2.18	2.20	0.07	13.6	6.2	1.10	.274	2.93	80	2.28	85	7.70	115.1
5	Chief Bender C. Bender	1,207	311	152	82	.650	235	2.25	178	26	29	2077.2	1,824	520	703	23	437	45	68	8,071	48	5.23	1.89	2.76	0.10	15.0	5.4	1.09	.283	3.05	81	2.10	77	7.90	138.8
6	Nap Rucker N. Rucker	1,203	327	132	133	.498	270	2.43	185	38	14	2338.0	2,055	632	809	41	694	72	54	9,292	43	4.63	2.67	1.73	0.16	12.9	7.5	1.18	.277	3.11	87	2.60	90	7.91	71.7
7	Red Ames R. Ames	1,146	340	117	106	.525	248	2.56	136	19	19	2076.2	1,857	591	848	30	689	44	64	8,476	97	4.97	2.99	1.66	0.13	13.5	8.1	1.23	.278	3.68	90	2.57	87	8.05	87.9
8	Mordecai Brown M. Brown	1,101	387	195	92	.679	257	1.98	205	46	48	2461.2	2,051	542	749	32	511	44	120	9,557	46	4.03	1.87	2.15	0.12	11.5	5.3	1.04	.257	2.74	68	2.33	81	7.50	147.9
9	Cy Falkenberg C. Falkenberg	1,070	293	120	110	.522	242	2.58	167	25	8	2063.0	1,868	592	826	21	601	61	38	8,277	81	4.67	2.62	1.78	0.09	12.9	7.3	1.20	.283	3.60	93	2.43	90	8.15	67.6
10	Grover Alexander G. Alexander	1,036	236	127	63	.668	188	2.32	147	37	12	1715.0	1,442	442	591	36	449	38	44	6,858	15	5.44	2.36	2.31	0.19	15.1	6.5	1.10	.265	3.10	72	2.51	76	7.57	145.9
11	Joe Wood J. Wood	986	218	117	56	.676	157	1.99	121	28	8	1416.0	1,117	313	485	10	412	49	51	5,564	43	6.27	2.62	2.39	0.06	17.7	7.4	1.08	.270	3.08	68	2.24	78	7.10	106.6
12	Bob Groom B. Groom	977	274	96	120	.444	229	3.10	138	17	6	1843.0	1,768	634	864	45	572	46	29	7,497	55	4.77	2.79	1.71	0.22	13.0	7.6	1.27	.294	4.22	105	2.78	97	8.63	21.9
13	Ed Reulbach E. Reulbach	929	339	157	85	.649	258	2.38	166	35	12	2209.0	1,789	585	765	31	763	84	66	8,844	40	3.78	3.11	1.22	0.13	10.5	8.6	1.16	.250	3.12	83	2.89	99	7.29	2
14	Jack Coombs J. Coombs	926	267	130	77	.628	215	2.59	152	30	8	1825.1	1,553	526	693	18	697	76	41	7,408	48	4.57	3.44	1.33	0.09	12.5	9.4	1.23	.270	3.42	92	2.84	104	7.66	-29.2
15	Rube Marquard R. Marquard	910	245	105	78	.574	192	2.90	99	16	13	1570.2	1,449	506	650	49	435	27	35	6,397	52	5.21	2.49	2.09	0.28	14.2	6.8	1.20	.281	3.72	99	2.69	88	8.30	64.8
16	George Mullin G. Mullin	905	322	158	121	.566	277	2.92	220	21	6	2376.0	2,304	771	1,050	29	768	97	38	9,750	52	3.43	2.91	1.18	0.11	9.3	7.9	1.29	.286	3.98	103	2.87	104	8.73	-23.6
17	Howie Camnitz H. Camnitz	894	316	132	102	.564	235	2.71	135	20	15	2036.1	1,804	614	818	41	636	62	66	8,218	35	3.95	2.81	1.41	0.18	10.9	7.7	1.20	.268	3.62	91	2.86	96	7.97	21.3
18	Jim Scott J. Scott	837	261	94	93	.503	188	2.29	109	23	5	1601.2	1,343	407	586	18	514	44	52	6,319	27	4.70	2.89	1.63	0.10	13.2	8.1	1.16	.270	3.29	85	2.61	95	7.55	20.5
19	Eddie Cicotte E. Cicotte	826	291	103	92	.528	206	2.48	126	16	10	1798.1	1,641	496	714	16	519	42	65	7,168	48	4.13	2.60	1.59	0.08	11.5	7.2	1.20	.282	3.57	88	2.60	93	8.21	39.8
20	Rube Waddell R. Waddell	817	171	67	59	.532	133	2.18	83	25	4	1096.1	913	266	394	5	323	41	27	4,319	24	6.71	2.65	2.53	0.04	18.9	7.5	1.13	.290	3.23	87	1.78	74	7.49	74.8
21	Earl Moore E. Moore	802	235	83	88	.485	181	3.00	96	19	5	1487.1	1,322	495	662	37	685	58	39	6,220	32	4.85	4.15	1.17	0.22	12.9	11.0	1.35	.277	4.01	96	3.22	104	8.00	-15.1
22	Frank Smith F. Smith	773	289	104	89	.539	201	2.73	135	19	6	1779.0	1,603	539	732	27	511	21	69	7,111	44	3.91	2.59	1.51	0.14	10.9	7.2	1.19	.273	3.70	102	2.54	100	8.11	-7.6
23	Orval Overall O. Overall	762	176	90	48	.652	143	2.10	101	28	12	1217.1	942	284	374	12	404	31	27	4,832	39	5.63	2.99	1.89	0.09	15.8	8.4	1.11	.257	2.77	79	2.20	81	6.96	69.2
24	Willie Mitchell W. Mitchell	751	207	61	71	.462	142	2.81	73	9	3	1257.2	1,103	393	565	8	477	56	47	5,147	41	5.37	3.41	1.57	0.06	14.6	9.3	1.26	.284	4.04	93	2.69	89	7.89	49.6
25	Hooks Wiltse H. Wiltse	740	301	111	81	.578	190	2.44	120	24	27	1750.2	1,584	474	650	41	376	31	89	6,937	27	3.80	1.93	1.97	0.21	10.7	5.4	1.12	.268	3.34	88	2.51	88	8.14	66