Between the 1907 and 1916 seasons, Walter Johnson fanned the most hitters, with 2,117 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Walter Johnson W. Johnson	2,117	419	231	148	.609	347	1.64	302	63	14	3148.1	2,421	575	854	26	629	113	67	12,089	110	6.05	1.80	3.37	0.07	17.5	5.2	0.97	.260	2.44	60	1.91	69	6.92	299.5
2	Ed Walsh E. Walsh	1,433	345	164	106	.607	260	1.74	210	45	32	2420.2	1,898	468	683	21	489	38	79	9,297	52	5.33	1.82	2.93	0.08	15.4	5.3	0.99	.257	2.54	65	1.99	77	7.06	146.5
3	Eddie Plank E. Plank	1,328	380	192	109	.638	302	2.21	217	47	22	2552.1	2,192	627	832	21	628	82	65	9,985	46	4.68	2.21	2.11	0.07	13.3	6.3	1.10	.274	2.93	80	2.31	85	7.73	111.5
4	Christy Mathewson C. Mathewson	1,294	381	223	105	.680	320	2.09	244	45	23	2795.0	2,507	648	898	64	335	14	51	10,928	36	4.17	1.08	3.86	0.21	11.8	3.1	1.02	.265	2.89	75	2.16	74	8.07	228.8
5	Nap Rucker N. Rucker	1,217	336	134	134	.500	274	2.42	186	38	14	2375.1	2,089	639	823	41	701	73	58	9,441	43	4.61	2.66	1.74	0.16	12.9	7.4	1.17	.276	3.12	86	2.60	90	7.92	73.7
6	Grover Alexander G. Alexander	1,203	284	160	75	.681	233	2.18	185	53	15	2104.0	1,765	509	681	42	499	48	47	8,358	18	5.15	2.13	2.41	0.18	14.4	6.0	1.08	.262	2.91	69	2.44	77	7.55	171.3
7	Chief Bender C. Bender	1,091	302	144	79	.646	221	2.31	158	26	29	1962.0	1,753	504	676	21	423	47	71	7,679	50	5.00	1.94	2.58	0.10	14.2	5.5	1.11	.284	3.10	83	2.16	79	8.04	118.4
8	Red Ames R. Ames	1,088	354	116	112	.509	248	2.56	131	20	26	2101.1	1,916	598	869	32	653	46	76	8,584	99	4.66	2.80	1.67	0.14	12.7	7.6	1.22	.278	3.72	90	2.58	88	8.21	82.2
9	Bob Groom B. Groom	1,069	315	109	129	.458	255	3.04	146	18	10	2060.1	1,942	696	946	46	670	49	37	8,369	57	4.67	2.93	1.60	0.20	12.8	8.0	1.27	.290	4.13	104	2.80	98	8.48	17.4
10	Rube Marquard R. Marquard	1,017	281	118	84	.584	213	2.75	114	18	18	1775.2	1,618	542	704	51	473	27	46	7,190	55	5.15	2.40	2.15	0.26	14.1	6.6	1.18	.279	3.57	94	2.61	86	8.20	81.3
11	Joe Wood J. Wood	986	218	117	56	.676	157	1.99	121	28	8	1416.0	1,117	313	485	10	412	49	51	5,564	43	6.27	2.62	2.39	0.06	17.7	7.4	1.08	.270	3.08	68	2.24	78	7.10	106.6
12	Mordecai Brown M. Brown	978	363	171	89	.658	229	2.14	180	37	45	2232.2	1,905	531	720	31	459	44	123	8,716	46	3.94	1.85	2.13	0.12	11.2	5.3	1.06	.260	2.90	73	2.35	81	7.68	129.2
13	Eddie Cicotte E. Cicotte	917	335	118	99	.544	225	2.42	137	18	15	1985.1	1,779	533	770	17	589	43	80	7,873	50	4.16	2.67	1.56	0.08	11.6	7.5	1.19	.279	3.49	86	2.59	93	8.06	44.5
14	Jim Scott J. Scott	908	293	101	107	.486	209	2.33	117	24	8	1767.0	1,498	457	649	21	567	47	59	6,976	32	4.62	2.89	1.60	0.11	13.0	8.1	1.17	.272	3.31	86	2.62	95	7.63	21.7
15	Cy Falkenberg C. Falkenberg	892	253	106	90	.541	206	2.54	137	23	7	1764.1	1,591	497	690	20	493	48	35	7,044	67	4.55	2.51	1.81	0.10	12.7	7.0	1.18	.281	3.52	90	2.43	89	8.12	65.1
16	Howie Camnitz H. Camnitz	889	314	131	102	.562	234	2.72	134	19	15	2027.1	1,798	612	816	41	631	62	65	8,181	35	3.95	2.80	1.41	0.18	10.9	7.7	1.20	.268	3.62	91	2.85	96	7.98	21.4
17	Jack Coombs J. Coombs	883	271	133	75	.639	216	2.61	149	32	8	1811.1	1,545	525	682	21	673	71	45	7,340	45	4.39	3.34	1.31	0.10	12.0	9.2	1.22	.268	3.39	93	2.86	105	7.68	-32.2
18	Ed Reulbach E. Reulbach	882	327	145	87	.625	245	2.46	152	29	9	2100.1	1,759	575	752	30	712	75	64	8,452	41	3.78	3.05	1.24	0.13	10.4	8.4	1.18	.256	3.22	86	2.87	99	7.54	5.1
19	Willie Mitchell W. Mitchell	835	242	70	81	.464	165	2.93	81	11	4	1429.0	1,277	465	653	10	544	61	58	5,867	46	5.26	3.43	1.53	0.06	14.2	9.3	1.27	.287	4.11	98	2.70	90	8.04	53.1
20	Earl Moore E. Moore	794	230	82	87	.485	177	2.98	94	19	5	1457.2	1,295	482	647	36	667	56	38	6,090	31	4.90	4.12	1.19	0.22	13.0	11.0	1.35	.277	3.99	95	3.20	102	8.00	-9.3
21	Claude Hendrix C. Hendrix	784	228	95	71	.572	161	2.52	123	21	16	1513.1	1,268	423	549	27	475	28	57	6,062	46	4.66	2.82	1.65	0.16	12.9	7.8	1.15	.261	3.26	84	2.73	92	7.54	36.8
22	George Mullin G. Mullin	782	282	137	103	.571	237	2.94	185	19	6	2046.0	1,989	669	911	26	660	82	38	8,389	41	3.44	2.90	1.18	0.11	9.3	7.9	1.29	.287	4.01	103	2.87	103	8.75	-14.8
23	Hippo Vaughn H. Vaughn	771	219	90	73	.552	172	2.60	104	20	4	1427.0	1,272	413	581	13	476	50	36	5,884	48	4.86	3.00	1.62	0.08	13.1	8.1	1.22	.275	3.66	89	2.61	89	8.02	51.3
24	Jeff Tesreau J. Tesreau	764	202	102	60	.630	178	2.35	109	25	7	1421.2	1,121	371	493	30	493	35	18	5,750	32	4.84	3.12	1.55	0.19	13.3	8.6	1.14	.246	3.12	85	2.82	97	7.10	7.8
25	Lefty Tyler L. Tyler	729	215	78	80	.494	171	3.15	112	18	5	1448.2	1,297	507	681	41	592	53	35	6,048	44	4.53	3.68	1.23	0.25	12.1	9.8	1.30	.271	4.23	100	3.24	102	8.06	-4.3