Between the 1908 and 1917 seasons, Walter Johnson struck out the most hitters, with 2,234 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Walter Johnson W. Johnson	2,234	452	249	155	.616	369	1.69	321	69	17	3364.0	2,569	632	924	28	677	125	77	12,912	113	5.98	1.81	3.30	0.07	17.3	5.2	0.96	.258	2.47	62	1.93	70	6.87	317.9
2	Grover Alexander G. Alexander	1,403	329	190	88	.683	277	2.12	219	61	15	2492.0	2,101	588	788	46	555	54	47	9,887	19	5.07	2.00	2.53	0.17	14.2	5.6	1.07	.262	2.85	69	2.35	75	7.59	207.7
3	Ed Walsh E. Walsh	1,231	293	140	89	.611	217	1.79	174	40	28	2016.1	1,579	400	572	18	411	31	70	7,757	39	5.49	1.83	3.00	0.08	15.9	5.3	0.99	.257	2.55	66	2.01	76	7.05	134.4
4	Eddie Plank E. Plank	1,171	357	173	99	.636	276	2.19	192	40	23	2339.2	2,015	569	756	18	581	67	66	9,142	42	4.50	2.23	2.02	0.07	12.8	6.4	1.11	.273	2.91	79	2.36	86	7.75	97.5
5	Bob Groom B. Groom	1,151	353	117	148	.442	283	3.03	157	22	13	2293.0	2,135	772	1,026	49	765	54	43	9,298	59	4.52	3.00	1.50	0.19	12.4	8.2	1.26	.287	4.03	105	2.82	100	8.38	8.3
6	Rube Marquard R. Marquard	1,134	318	137	96	.588	242	2.72	128	20	18	2008.1	1,818	608	788	56	533	27	50	8,132	59	5.08	2.39	2.13	0.25	13.9	6.6	1.17	.276	3.53	94	2.57	87	8.15	88.3
7	Christy Mathewson C. Mathewson	1,116	340	199	93	.682	284	2.10	213	37	21	2480.0	2,257	578	810	59	282	12	47	9,693	31	4.05	1.02	3.96	0.21	11.5	2.9	1.02	.267	2.94	74	2.21	75	8.19	198.1
8	Nap Rucker N. Rucker	1,086	299	119	121	.496	244	2.47	160	34	14	2100.0	1,847	576	729	38	621	65	51	8,351	33	4.65	2.66	1.75	0.16	13.0	7.4	1.18	.277	3.12	86	2.63	90	7.92	68.9
9	Eddie Cicotte E. Cicotte	1,067	384	146	111	.568	260	2.28	166	25	19	2332.0	2,025	592	846	19	659	46	91	9,160	51	4.12	2.54	1.62	0.07	11.6	7.2	1.15	.272	3.27	82	2.52	90	7.82	70.7
10	Chief Bender C. Bender	1,022	289	136	73	.651	207	2.30	146	26	28	1855.2	1,652	475	633	21	415	51	72	7,277	48	4.96	2.01	2.46	0.10	14.0	5.7	1.11	.283	3.07	82	2.24	81	8.01	103.9
11	Red Ames R. Ames	1,004	358	121	110	.524	241	2.62	124	20	28	2077.0	1,921	605	851	30	602	39	85	8,472	84	4.35	2.61	1.67	0.13	11.9	7.1	1.21	.278	3.69	92	2.58	88	8.32	79.8
12	Joe Wood J. Wood	988	223	117	57	.672	158	2.01	121	28	9	1431.2	1,134	319	492	10	419	49	54	5,626	43	6.21	2.63	2.36	0.06	17.6	7.4	1.08	.270	3.09	69	2.25	78	7.13	106
13	Hippo Vaughn H. Vaughn	966	260	113	86	.568	210	2.50	131	25	4	1722.2	1,527	479	678	16	567	59	38	7,100	50	5.05	2.96	1.70	0.08	13.6	8.0	1.22	.275	3.54	86	2.52	87	7.98	70.4
14	Jim Scott J. Scott	945	317	107	114	.484	226	2.30	123	26	9	1892.0	1,624	483	686	21	609	53	63	7,487	32	4.50	2.90	1.55	0.10	12.6	8.1	1.18	.274	3.26	85	2.63	96	7.73	21.2
15	Willie Mitchell W. Mitchell	915	272	82	89	.480	187	2.84	93	16	4	1614.1	1,449	510	719	12	590	74	65	6,614	46	5.10	3.29	1.55	0.07	13.8	8.9	1.26	.286	4.01	96	2.67	90	8.08	59.8
16	Mordecai Brown M. Brown	871	329	151	83	.645	202	2.23	160	31	42	1999.2	1,725	495	669	29	419	38	116	7,855	42	3.92	1.89	2.08	0.13	11.1	5.3	1.07	.261	3.01	75	2.40	82	7.76	112
17	Claude Hendrix C. Hendrix	865	268	105	83	.559	182	2.53	136	22	17	1728.1	1,470	485	643	30	547	32	72	6,954	54	4.50	2.85	1.58	0.16	12.4	7.9	1.17	.263	3.35	85	2.73	93	7.65	35.3
18	Jeff Tesreau J. Tesreau	849	235	115	68	.628	198	2.43	120	26	9	1605.1	1,289	434	564	36	551	38	24	6,507	40	4.76	3.09	1.54	0.20	13.0	8.5	1.15	.249	3.16	89	2.81	99	7.23	1.1
19	Jack Coombs J. Coombs	844	279	134	77	.635	213	2.68	148	30	6	1819.2	1,583	541	700	26	658	70	56	7,386	38	4.17	3.25	1.28	0.13	11.4	8.9	1.23	.269	3.46	95	2.91	107	7.83	-41.8
20	Lefty Tyler L. Tyler	827	247	92	92	.500	199	3.06	134	22	6	1687.2	1,500	574	762	42	678	59	38	7,018	51	4.41	3.62	1.22	0.22	11.8	9.7	1.29	.269	4.06	99	3.16	102	8.00	-10
21	Cy Falkenberg C. Falkenberg	819	236	102	79	.564	190	2.60	124	22	6	1611.1	1,482	466	638	21	442	40	35	6,428	61	4.57	2.47	1.85	0.12	12.7	6.9	1.19	.286	3.56	91	2.45	87	8.28	70.3
22	Howie Camnitz H. Camnitz	804	283	118	94	.557	215	2.77	119	15	14	1847.1	1,663	569	751	41	572	59	55	7,480	30	3.92	2.79	1.41	0.20	10.7	7.6	1.21	.270	3.66	91	2.91	97	8.10	14.2
23	Ed Reulbach E. Reulbach	795	305	128	84	.604	225	2.55	136	25	9	1930.2	1,633	546	717	29	663	67	61	7,806	39	3.71	3.09	1.20	0.14	10.2	8.5	1.19	.257	3.34	88	2.92	100	7.61	-3.1
24	Larry Cheney L. Cheney	791	255	102	77	.570	192	2.54	110	20	18	1551.1	1,279	437	625	31	602	46	45	6,445	98	4.59	3.49	1.31	0.18	12.3	9.3	1.21	.251	3.63	86	2.99	101	7.42	-1
25	Earl Moore E. Moore	759	215	79	80	.497	166	2.91	90	19	4	1374.1	1,205	444	584	35	629	51	34	5,723	26	4.97	4.12	1.21	0.23	13.3	11.0	1.33	.275	3.82	92	3.21	101	7.89	-4.7