Between the 1909 and 1918 seasons, Walter Johnson struck out the most hitters, with 2,236 strikeouts.

	NAME	SO	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Walter Johnson W. Johnson	2,236	455	258	154	.626	368	1.65	327	71	19	3433.2	2,616	631	920	30	694	122	81	13,188	108	5.86	1.82	3.22	0.08	17.0	5.3	0.96	.256	2.41	60	1.97	70	6.86	328.8
2	Grover Alexander G. Alexander	1,418	332	192	89	.683	280	2.12	222	61	15	2518.0	2,120	593	795	46	558	55	47	9,985	19	5.07	1.99	2.54	0.16	14.2	5.6	1.06	.262	2.84	69	2.34	75	7.58	211.3
3	Rube Marquard R. Marquard	1,221	351	146	113	.564	270	2.71	147	24	18	2242.1	2,043	676	880	63	590	27	53	9,090	61	4.90	2.37	2.07	0.25	13.4	6.5	1.17	.275	3.53	94	2.57	88	8.20	92.5
4	Bob Groom B. Groom	1,159	367	119	150	.442	288	3.10	157	22	13	2336.1	2,205	806	1,068	49	783	55	47	9,501	59	4.46	3.02	1.48	0.19	12.2	8.2	1.28	.289	4.11	107	2.83	100	8.49	7.4
5	Hippo Vaughn H. Vaughn	1,112	293	135	96	.584	243	2.39	158	33	4	2010.2	1,742	534	752	20	639	66	39	8,236	54	4.98	2.86	1.74	0.09	13.5	7.8	1.18	.269	3.37	82	2.48	86	7.80	88.4
6	Eddie Cicotte E. Cicotte	1,076	383	147	118	.555	266	2.33	173	24	19	2390.2	2,102	618	871	21	640	37	85	9,405	39	4.05	2.41	1.68	0.08	11.4	6.8	1.15	.273	3.28	82	2.49	88	7.91	91.7
7	Eddie Plank E. Plank	1,036	323	159	83	.657	248	2.19	171	36	22	2095.0	1,813	510	685	17	535	58	61	8,186	35	4.45	2.30	1.94	0.07	12.7	6.5	1.12	.275	2.94	78	2.44	87	7.79	82
8	Red Ames R. Ames	991	367	123	120	.506	251	2.63	136	20	28	2169.1	2,017	635	891	31	627	43	85	8,875	87	4.11	2.60	1.58	0.13	11.2	7.1	1.22	.276	3.70	92	2.63	90	8.37	70.7
9	Joe Wood J. Wood	977	217	116	56	.674	156	2.00	120	27	9	1409.0	1,120	313	480	10	403	48	51	5,522	43	6.24	2.57	2.42	0.06	17.7	7.3	1.08	.272	3.07	69	2.23	77	7.15	108.6
10	Ed Walsh E. Walsh	962	227	100	74	.575	168	1.90	132	29	22	1552.1	1,236	327	461	16	355	22	54	6,002	29	5.58	2.06	2.71	0.09	16.0	5.9	1.02	.263	2.67	66	2.19	78	7.17	100.2
11	Claude Hendrix C. Hendrix	951	300	125	90	.581	209	2.56	157	25	17	1961.1	1,699	557	730	32	601	37	76	7,920	62	4.36	2.76	1.58	0.15	12.0	7.6	1.17	.265	3.35	86	2.69	92	7.80	46.3
12	Jim Scott J. Scott	945	317	107	114	.484	226	2.30	123	26	9	1892.0	1,624	483	686	21	609	53	63	7,487	32	4.50	2.90	1.55	0.10	12.6	8.1	1.18	.274	3.26	85	2.63	96	7.73	21.2
13	Chief Bender C. Bender	937	271	128	64	.667	190	2.35	132	24	27	1717.0	1,531	448	585	20	394	48	71	6,740	46	4.91	2.07	2.38	0.10	13.9	5.8	1.12	.283	3.07	83	2.30	82	8.03	91.6
14	Lefty Tyler L. Tyler	929	280	111	100	.526	229	2.92	156	28	7	1957.0	1,718	634	834	43	745	64	41	8,084	52	4.27	3.43	1.25	0.20	11.5	9.2	1.26	.266	3.84	95	3.04	100	7.90	3.9
15	Willie Mitchell W. Mitchell	917	273	82	90	.477	188	2.86	93	16	4	1618.1	1,452	514	723	12	595	74	65	6,634	46	5.10	3.31	1.54	0.07	13.8	9.0	1.26	.286	4.02	96	2.68	90	8.07	58.8
16	Nap Rucker N. Rucker	887	257	102	102	.500	207	2.54	130	28	13	1766.2	1,582	499	622	37	496	46	47	7,059	28	4.52	2.53	1.79	0.19	12.6	7.0	1.18	.276	3.17	85	2.71	89	8.06	65.9
17	Jeff Tesreau J. Tesreau	880	247	119	72	.623	207	2.43	123	27	9	1679.0	1,350	453	591	37	572	38	25	6,805	42	4.72	3.07	1.54	0.20	12.9	8.4	1.14	.249	3.17	89	2.79	99	7.24	2.5
18	Larry Cheney L. Cheney	874	287	113	90	.557	213	2.59	125	20	19	1752.0	1,456	504	709	33	676	56	55	7,295	111	4.49	3.47	1.29	0.17	12.0	9.3	1.22	.252	3.64	89	2.97	101	7.48	-1.5
19	Christy Mathewson C. Mathewson	857	284	162	82	.664	240	2.22	179	26	16	2089.1	1,976	516	725	54	240	9	38	8,224	29	3.69	1.03	3.57	0.23	10.4	2.9	1.06	.272	3.12	76	2.38	79	8.51	145.7
20	Jack Coombs J. Coombs	808	280	135	86	.611	215	2.85	154	28	6	1855.2	1,644	587	734	35	643	69	54	7,554	37	3.92	3.12	1.26	0.17	10.7	8.5	1.23	.268	3.56	100	2.99	108	7.97	-49.5
21	Ray Caldwell R. Caldwell	803	248	96	99	.492	196	3.00	150	17	4	1718.1	1,519	572	684	41	576	52	42	6,870	22	4.21	3.02	1.39	0.21	11.7	8.4	1.22	.274	3.58	99	2.95	98	7.96	16.2
22	Dutch Leonard D. Leonard	771	211	90	64	.584	161	2.13	96	25	11	1361.1	1,134	322	425	16	412	41	40	5,375	32	5.10	2.72	1.87	0.11	14.3	7.7	1.14	.270	2.81	79	2.39	86	7.50	54.5
23	Cy Falkenberg C. Falkenberg	768	211	94	73	.563	175	2.60	117	21	6	1482.1	1,360	428	584	18	411	36	29	5,913	53	4.66	2.50	1.87	0.11	13.0	7.0	1.19	.287	3.55	89	2.45	85	8.26	74.5
24	Mordecai Brown M. Brown	748	285	122	74	.622	171	2.37	133	22	37	1687.1	1,511	444	605	28	370	33	104	6,702	36	3.99	1.97	2.02	0.15	11.2	5.5	1.11	.269	3.23	77	2.50	83	8.06	90.5
25	Earl Moore E. Moore	743	212	77	79	.494	163	2.96	87	18	4	1348.1	1,185	444	580	35	621	49	34	5,621	25	4.96	4.15	1.20	0.23	13.2	11.0	1.34	.276	3.87	93	3.23	102	7.91	-5.9