Between the 1973 and 2021 seasons, Greg Maddux won the most games, with 355 wins.

Interpreted as:

most pitcher regular-season wins from 1973 to 2021

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Greg Maddux G. Maddux	355	227	.610	744	740	3.16	3,371	109	35	0	5008.1	4,726	1,756	1,981	353	999	137	3	177	20,421	70	6.06	1.80	3.37	0.63	16.5	4.9	1.14	.281	3.56	76	3.25	78	8.49	519.5
2	Roger Clemens R. Clemens	354	184	.658	709	707	3.12	4,672	118	46	0	4916.2	4,185	1,707	1,885	363	1,580	159	0	63	20,240	143	8.55	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	70	3.08	71	7.66	680.4
3	Tom Glavine T. Glavine	305	203	.600	682	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	1,900	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	86	3.94	94	8.76	120.1
4	Randy Johnson R. Johnson	303	166	.646	618	603	3.29	4,875	100	37	2	4135.1	3,346	1,513	1,703	411	1,497	190	7	37	17,067	109	10.61	3.26	3.26	0.89	28.6	8.8	1.17	.291	3.71	75	3.18	73	7.28	554.3
5	Nolan Ryan N. Ryan	276	238	.537	663	660	3.21	4,892	189	50	1	4592.0	3,388	1,636	1,868	273	2,294	124	3	60	19,195	236	9.59	4.50	2.13	0.54	25.5	12.0	1.24	.268	3.66	89	2.92	81	6.64	369.5
6	Mike Mussina M. Mussina	270	153	.638	537	536	3.68	2,813	57	23	0	3562.2	3,460	1,458	1,559	376	785	60	0	29	14,593	71	7.11	1.98	3.58	0.95	19.3	5.4	1.19	.292	3.94	82	3.57	79	8.74	372.8
7	Jamie Moyer J. Moyer	269	209	.563	696	638	4.25	2,441	33	10	0	4074.0	4,231	1,926	2,076	522	1,155	146	15	69	17,356	57	5.39	2.55	2.11	1.15	14.1	6.7	1.32	.283	4.59	97	4.46	102	9.35	-33.5
8	Andy Pettitte A. Pettitte	256	153	.626	531	521	3.85	2,448	26	4	0	3316.0	3,448	1,418	1,572	288	1,031	55	3	42	14,074	69	6.64	2.80	2.37	0.78	17.4	7.3	1.35	.308	4.27	86	3.73	83	9.36	282.1
9	Jack Morris J. Morris	254	186	.577	549	527	3.90	2,478	175	28	0	3824.0	3,567	1,657	1,815	389	1,390	58	10	99	16,120	206	5.83	3.27	1.78	0.92	15.4	8.6	1.30	.269	4.27	96	3.93	95	8.40	93
10	CC Sabathia	251	161	.609	561	560	3.74	3,093	38	12	0	3577.1	3,404	1,485	1,623	382	1,099	123	0	44	14,989	74	7.78	2.76	2.81	0.96	20.6	7.3	1.26	.294	4.08	87	3.77	87	8.56	223.7
11	Bartolo Colon B. Colon	247	188	.568	565	552	4.12	2,535	38	13	0	3461.2	3,593	1,584	1,719	439	948	64	2	47	14,655	45	6.59	2.46	2.67	1.14	17.3	6.5	1.31	.296	4.47	95	4.14	96	9.34	71.6
12	Dennis Martinez D. Martinez	245	193	.559	692	562	3.70	2,149	122	30	8	3999.2	3,897	1,643	1,835	372	1,165	122	51	71	16,754	83	4.84	2.62	1.84	0.84	12.8	7.0	1.27	.272	4.13	94	3.91	99	8.77	17
13	Bert Blyleven B. Blyleven	244	209	.539	588	584	3.39	3,114	209	51	0	4240.1	3,975	1,598	1,775	370	1,147	138	1	57	17,532	100	6.61	2.43	2.71	0.79	17.8	6.5	1.21	.282	3.77	86	3.26	83	8.44	299.8
14	Frank Tanana F. Tanana	240	236	.504	638	616	3.66	2,773	143	34	1	4188.1	4,063	1,704	1,910	448	1,255	129	10	116	17,641	119	5.96	2.70	2.21	0.96	15.7	7.1	1.27	.277	4.10	94	3.78	96	8.73	66.4
15	David Wells D. Wells	239	157	.604	660	489	4.13	2,201	54	12	13	3439.0	3,635	1,578	1,702	407	719	83	65	65	14,413	101	5.76	1.88	3.06	1.07	15.3	5.0	1.27	.293	4.45	93	3.99	90	9.51	172.9
16	Justin Verlander J. Verlander	226	129	.637	454	454	3.33	3,013	26	9	0	2988.0	2,538	1,105	1,192	310	851	98	0	27	12,214	87	9.08	2.56	3.54	0.93	24.7	7.0	1.13	.281	3.59	78	3.40	80	7.64	280.4
17	Steve Carlton S. Carlton	225	172	.567	510	496	3.37	2,875	158	31	1	3606.0	3,246	1,352	1,550	308	1,297	35	6	102	15,024	123	7.18	3.24	2.22	0.77	19.1	8.6	1.26	.280	3.87	89	3.30	88	8.10	168.7
18	Tim Hudson T. Hudson	222	133	.625	482	479	3.49	2,080	26	13	0	3126.2	2,957	1,213	1,319	248	917	124	0	84	13,005	84	5.99	2.64	2.27	0.71	16.0	7.1	1.24	.281	3.80	83	3.78	90	8.51	152.3
19	Don Sutton D. Sutton	222	162	.578	515	511	3.34	2,215	103	30	2	3524.2	3,161	1,308	1,439	343	888	49	3	54	14,451	68	5.66	2.27	2.49	0.88	15.3	6.1	1.15	.257	3.67	91	3.48	93	8.07	101.3
20	Phil Niekro P. Niekro	221	190	.538	548	522	3.53	2,301	154	27	7	3735.1	3,557	1,465	1,675	337	1,405	86	17	54	15,843	139	5.54	3.39	1.64	0.81	14.5	8.9	1.33	.275	4.04	89	3.81	96	8.57	59.1
21	Zack Greinke Z. Greinke	219	132	.624	530	488	3.41	2,809	17	5	1	3110.0	2,892	1,179	1,263	328	712	72	8	25	12,699	92	8.13	2.06	3.95	0.95	22.1	5.6	1.16	.292	3.65	81	3.43	83	8.37	244.3
22	Pedro Martinez P. Martinez	219	100	.687	476	409	2.93	3,154	46	17	3	2827.1	2,221	919	1,006	239	760	141	23	30	11,394	62	10.04	2.42	4.15	0.76	27.7	6.7	1.05	.279	3.20	66	2.91	68	7.07	454.6
23	Kenny Rogers K. Rogers	219	156	.584	762	474	4.27	1,968	36	9	28	3302.2	3,457	1,568	1,739	339	1,175	127	133	53	14,280	79	5.36	3.20	1.67	0.92	13.8	8.2	1.40	.292	4.74	93	4.38	97	9.42	43.3
24	Curt Schilling C. Schilling	216	146	.597	569	436	3.46	3,116	83	20	22	3261.0	2,998	1,253	1,318	347	711	52	81	43	13,284	72	8.60	1.96	4.38	0.96	23.5	5.4	1.14	.293	3.64	80	3.22	76	8.27	373.6
25	Charlie Hough C. Hough	216	216	.500	844	440	3.74	2,346	107	13	59	3777.1	3,260	1,569	1,792	375	1,649	173	230	44	16,059	179	5.59	3.93	1.42	0.89	14.6	10.3	1.30	.251	4.27	95	4.26	108	7.77	-130.2