Walter Johnson has the most career wins versus the Red Sox, with 53 wins.

Interpreted as:

most pitching regular-season wins by a player against red sox

	NAME	W	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	53	43	.552	112	91	1.62	488	75	15	6	815.0	670		233	6	180	31	20			12	5.39	1.99	2.71	0.07		5.6	1.04	.262	2.57	7.40
2	Eddie Plank E. Plank	49	31	.613	94	82	1.25	339	65	8	2	691.0	596		230	10	154	30	11			15	4.42	2.01	2.20	0.13		5.8	1.09	.277	3.00	7.76
3	Mel Harder M. Harder	44	30	.595	96	79	3.62	234	35	6	3	594.2	659	239	289	31	178	6	13		2,575	3	3.54	2.69	1.31	0.47	9.1	6.9	1.41	.295	4.37	9.97
4	Early Wynn E. Wynn	39	33	.542	97	84	3.90	376	40	7	3	630.0	620	273	310	58	274	9	11	10	2,750	13	5.37	3.91	1.37	0.83	13.7	10.0	1.42	.276	4.43	8.86
5	Ted Lyons T. Lyons	39	28	.582	80	68	2.96	152	58	6	3	603.0	586	198	234	20	141	2	10		2,500	9	2.27	2.10	1.08	0.30	6.1	5.6	1.21	.259	3.49	8.75
6	Eddie Rommel E. Rommel	38	12	.760	77	44	2.80	102	29	4	3	424.2	440	132	168	21	78	6	24		1,762	4	2.16	1.65	1.31	0.45	5.8	4.4	1.22	.269	3.56	9.32
7	Stan Coveleski S. Coveleski	38	15	.717	59	54	2.32	103	35	10	1	442.2	407	114	134	2	118	6	4		1,818	6	2.09	2.40	0.87	0.04	5.7	6.5	1.19	.255	2.72	8.27
8	Red Faber R. Faber	36	30	.545	99	67	2.93	187	38	3	6	565.0	562		251	4	155	11	26			6	2.98	2.47	1.21	0.06		6.5	1.27	.274	4.00	8.95
9	Hooks Dauss H. Dauss	36	23	.610	83	61	2.80	184	40	8	8	534.0	506		220	10	183	23	17			3	3.10	3.08	1.01	0.17		8.1	1.29	.266	3.71	8.53
10	Lefty Grove L. Grove	35	8	.814	57	40	2.71	258	27	4	6	361.2	322	109	124	7	109	8	15		1,483	3	6.42	2.71	2.37	0.17	17.4	7.3	1.19	.286	3.09	8.01
11	Herb Pennock H. Pennock	35	9	.795	61	45	3.02	143	30	5	0	397.0	397		168	11	102	7	8		1,669	13	3.24	2.31	1.40	0.25	8.6	6.1	1.26	.275	3.81	9.00
12	Ed Walsh E. Walsh	35	14	.714	65	44	0.44	294	40	15	7	453.1	313		106	4	98	8	21			10	5.84	1.95	3.00	0.08		6.5	0.91	.278	2.10	6.21
13	Jim Perry J. Perry	34	21	.618	76	54	3.39	192	17	6	2	424.1	412	160	185	47	149	5	10	14	1,806	7	4.07	3.16	1.29	1.00	10.6	8.3	1.32	.258	3.92	8.74
14	Bob Feller B. Feller	33	27	.550	84	68	4.11	370	31	4	2	519.0	481	237	257	39	276	3	9	3	2,253	7	6.42	4.79	1.34	0.68	16.4	12.3	1.46	.282	4.46	8.34
15	Bob Shawkey B. Shawkey	32	23	.582	73	51	2.35	222	34	5	5	467.0	408	122	164	9	151	5	18		1,916	9	4.28	2.91	1.47	0.17	11.6	7.9	1.20	.261	3.16	7.86
16	Bob Lemon B. Lemon	31	17	.646	65	52	3.44	178	29	2	4	432.0	392	165	190	24	226	9	6		1,873	15	3.71	4.71	0.79	0.50	9.5	12.1	1.43	.256	3.96	8.17
17	Earl Whitehill E. Whitehill	30	11	.732	54	49	3.85	175	28	0	1	395.1	406	169	194	6	136	9	5		1,706	3	3.98	3.10	1.29	0.14	10.3	8.0	1.37	.290	4.42	9.24
18	Red Ruffing R. Ruffing	29	16	.644	55	53	3.39	221	37	7	1	422.1	390	159	184	37	138	5	2		1,756	4	4.71	2.94	1.60	0.79	12.6	7.9	1.25	.261	3.92	8.31
19	Firpo Marberry F. Marberry	29	9	.763	73	34	3.21	127	18	1	7	347.1	323	124	142	8	101	7	28		1,445	3	3.29	2.62	1.26	0.21	8.8	7.0	1.22	.262	3.68	8.37
20	George Uhle G. Uhle	29	18	.617	64	43	3.34	131	32	4	6	404.0	404		178	9	89	15	16		1,701	4	2.92	1.98	1.47	0.20	7.7	5.2	1.22	.271	3.97	9.00
21	Tommy Bridges T. Bridges	28	23	.549	61	52	3.99	219	26	3	1	397.0	405	176	211	27	195	3	8		1,760	8	4.96	4.42	1.12	0.61	12.4	11.1	1.51	.287	4.78	9.18
22	Willis Hudlin W. Hudlin	27	26	.509	73	52	3.88	105	29	1	3	435.2	485	188	223	15	117	8	11		1,882	4	2.17	2.42	0.90	0.31	5.6	6.2	1.38	.287	4.61	10.02
23	Tommy Thomas T. Thomas	27	16	.628	60	48	3.07	143	29	1	0	398.2	370	136	162	19	102	7	8		1,646	6	3.23	2.30	1.40	0.43	8.7	6.2	1.18	.255	3.66	8.35
24	Ed Killian E. Killian	27	11	.711	44	40	0.39	100	33	3	0	343.1	314		114	5	86	14	3			3	2.62	2.25	1.16	0.13		6.5	1.17	.275	2.99	8.23
25	Elam Vangilder E. Vangilder	26	15	.634	54	39	2.83	78	23	5	2	318.0	296	100	132	12	101	11	9		1,338	0	2.21	2.86	0.77	0.34	5.8	7.5	1.25	.250	3.74	8.38