Since 2000, the Chicago White Sox have won their most games in a season in 2005, with 99 wins.

Interpreted as:

most pitching wins in a regular season since 2000 white sox

	TEAM	W	SEASON	L	W%	G	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	White Sox	99	2005	63	.611	162	162	3.61	1,040	9	4	54	1475.2	1,392	592	645	167	459	52	42	6,176	65	6.34	2.80	2.27	1.02	16.8	7.4	1.25	.275	3.93	8.49
2	White Sox	95	2000	67	.586	162	162	4.66	1,037	5	2	43	1450.1	1,509	751	839	195	614	54	27	6,337	43	6.44	3.81	1.69	1.21	16.4	9.7	1.46	.296	5.21	9.36
3	White Sox	93	2021	69	.574	162	162	3.73	1,588	4	3	43	1403.1	1,205	581	636	182	485	51	16	5,861	84	10.18	3.11	3.27	1.17	27.1	8.3	1.20	.288	4.08	7.73
4	White Sox	90	2006	72	.556	162	162	4.61	1,012	5	2	46	1449.0	1,534	743	794	200	433	58	59	6,232	51	6.29	2.69	2.34	1.24	16.2	6.9	1.36	.295	4.93	9.53
5	White Sox	89	2008	74	.546	163	163	4.06	1,147	4	0	34	1457.2	1,471	658	729	156	460	48	42	6,218	54	7.08	2.84	2.49	0.96	18.4	7.4	1.32	.298	4.50	9.08
6	White Sox	88	2010	74	.543	162	162	4.09	1,149	6	2	43	1446.1	1,471	658	704	136	490	34	41	6,180	59	7.15	3.05	2.34	0.85	18.6	7.9	1.36	.305	4.38	9.15
7	White Sox	86	2003	76	.531	162	162	4.17	1,056	12	0	36	1431.0	1,364	663	715	162	518	53	30	6,067	39	6.64	3.26	2.04	1.02	17.4	8.5	1.32	.281	4.50	8.58
8	White Sox	85	2012	77	.525	162	162	4.02	1,246	6	2	37	1445.2	1,365	646	676	186	503	68	29	6,098	66	7.76	3.13	2.48	1.16	20.4	8.2	1.29	.288	4.21	8.50
9	White Sox	83	2004	79	.512	162	162	4.91	1,013	8	2	34	1432.1	1,505	782	831	224	527	48	36	6,189	43	6.37	3.31	1.92	1.41	16.4	8.5	1.42	.293	5.22	9.46
10	White Sox	83	2001	79	.512	162	162	4.55	921	8	3	51	1433.1	1,465	725	795	181	500	88	38	6,200	57	5.78	3.14	1.84	1.14	14.9	8.1	1.37	.285	4.99	9.20
11	White Sox	81	2022	81	.500	162	162	3.92	1,450	2	1	48	1447.2	1,330	631	717	166	533	51	15	6,145	64	9.01	3.31	2.72	1.03	23.6	8.7	1.29	.295	4.46	8.27
12	White Sox	81	2002	81	.500	162	162	4.53	945	7	4	35	1423.0	1,422	716	798	190	528	60	31	6,131	54	5.98	3.34	1.79	1.20	15.4	8.6	1.37	.279	5.05	8.99
13	White Sox	79	2011	83	.488	162	162	4.10	1,220	6	4	42	1460.0	1,463	665	706	147	439	44	50	6,188	55	7.52	2.71	2.78	0.91	19.7	7.1	1.30	.303	4.35	9.02
14	White Sox	79	2009	83	.488	162	162	4.14	1,119	4	1	36	1439.2	1,438	663	732	169	507	41	41	6,155	55	7.00	3.17	2.21	1.06	18.2	8.2	1.35	.294	4.58	8.99
15	White Sox	78	2016	84	.481	162	162	4.10	1,270	7	1	43	1446.2	1,422	659	715	185	521	68	30	6,196	72	7.90	3.24	2.44	1.15	20.5	8.4	1.34	.298	4.45	8.85
16	White Sox	76	2015	86	.469	162	162	3.98	1,359	7	4	37	1452.2	1,443	643	701	162	474	62	34	6,181	61	8.42	2.94	2.87	1.00	22.0	7.7	1.32	.311	4.34	8.94
17	White Sox	73	2014	89	.451	162	162	4.29	1,152	3	0	36	1441.0	1,468	687	758	140	557	69	42	6,255	75	7.20	3.48	2.07	0.87	18.4	8.9	1.41	.306	4.73	9.17
18	White Sox	72	2019	89	.447	161	161	4.90	1,312	6	2	33	1412.2	1,438	769	832	238	582	51	30	6,159	71	8.36	3.71	2.25	1.52	21.3	9.4	1.43	.302	5.30	9.16
19	White Sox	72	2007	90	.444	162	162	4.77	1,015	9	4	42	1440.2	1,556	763	839	174	499	59	50	6,293	45	6.34	3.12	2.03	1.09	16.1	7.9	1.43	.304	5.24	9.72
20	White Sox	67	2017	95	.414	162	162	4.78	1,193	0	0	25	1421.2	1,384	755	820	242	632	68	36	6,200	67	7.55	4.00	1.89	1.53	19.2	10.2	1.42	.281	5.19	8.76
21	White Sox	63	2013	99	.389	162	162	3.98	1,249	5	1	40	1455.0	1,424	643	723	182	509	60	24	6,214	62	7.73	3.15	2.45	1.13	20.1	8.2	1.33	.295	4.47	8.81
22	White Sox	62	2018	100	.383	162	162	4.83	1,259	0	0	34	1437.0	1,404	771	848	196	653	89	25	6,339	94	7.89	4.09	1.93	1.23	19.9	10.3	1.43	.292	5.31	8.79
23	White Sox	61	2023	101	.377	162	162	4.87	1,470	2	0	28	1431.2	1,372	774	841	214	654	91	14	6,301	64	9.24	4.11	2.25	1.35	23.3	10.4	1.42	.299	5.29	8.62
24	White Sox	60	2025	102	.370	162	162	4.26	1,286	0	0	25	1416.0	1,336	671	742	189	595	72	29	6,124	48	8.17	3.78	2.16	1.20	21.0	9.7	1.36	.288	4.72	8.49
25	White Sox	41	2024	121	.253	162	162	4.67	1,366	0	0	21	1420.0	1,397	737	813	201	643	54	25	6,241	61	8.66	4.08	2.12	1.27	21.9	10.3	1.44	.301	5.15	8.85