most point differential in a mlb game in 2022

The Toronto Blue Jays had the highest run differential by a team in a game in 2022, with a differential of 23 runs versus the Red Sox on July 22, 2022.

Interpreted as:

most point differential in a MLB regular-season game in 2022

	TEAM	DIFF	DATE	TM		OPP	RESULT	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Blue Jays	23	7/22/2022	TOR	@	BOS	W 28-5	57	28	29	5	0	5	28	5	1	9	0	0	63	49	10	0	0	0	0	.509	.556	.860	1.415
2	Cubs	21	4/23/2022	CHC	vs	PIT	W 21-0	48	21	23	4	0	1	19	4	1	3	2	0	53	30	5	0	0	0	1	.479	.528	.625	1.153
3	Brewers	17	7/1/2022	MIL	@	PIT	W 19-2	44	19	16	5	0	5	18	7	0	2	2	0	51	36	10	0	0	0	0	.364	.451	.818	1.269
4	Phillies	16	8/31/2022	PHI	@	ARI	W 18-2	49	18	24	6	1	0	15	8	0	6	0	0	57	32	7	0	0	0	2	.490	.561	.653	1.214
5	Astros	16	8/18/2022	HOU	@	CWS	W 21-5	51	21	25	5	0	4	21	4	0	9	1	0	55	42	9	0	0	0	1	.490	.527	.824	1.351
6	Yankees	16	7/6/2022	NYY	@	PIT	W 16-0	46	16	22	4	0	6	16	8	0	10	3	0	55	44	10	0	1	0	2	.478	.545	.957	1.502
7	Reds	15	5/26/2022	CIN	vs	CHC	W 20-5	38	20	20	3	1	2	20	7	0	4	0	1	49	31	6	1	3	1	0	.526	.563	.816	1.378
8	Padres	14	6/15/2022	SDP	@	CHC	W 19-5	46	19	21	7	1	3	19	6	2	5	0	0	55	39	11	0	1	1	1	.457	.527	.848	1.375
9	Yankees	14	6/12/2022	NYY	vs	CHC	W 18-4	41	18	17	4	0	4	18	7	0	7	0	0	48	33	8	0	0	0	0	.415	.500	.805	1.305
10	Cardinals	14	5/22/2022	STL	@	PIT	W 18-4	47	18	20	5	0	3	18	4	0	4	1	0	52	34	8	0	1	0	0	.426	.462	.723	1.185
11	Brewers	14	5/4/2022	MIL	vs	CIN	W 18-4	39	18	17	3	0	3	18	9	2	6	0	0	51	29	6	0	1	0	1	.436	.549	.744	1.293
12	Guardians	14	4/10/2022	CLE	@	KCR	W 17-3	48	17	22	3	2	2	17	4	1	10	0	0	53	35	7	0	0	0	1	.458	.509	.729	1.239
13	Cubs	13	10/5/2022	CHC	@	CIN	W 15-2	39	15	13	3	0	3	15	8	1	10	1	1	48	25	6	0	0	1	0	.333	.458	.641	1.099
14	Red Sox	13	9/10/2022	BOS	@	BAL	W 17-4	46	17	21	3	0	2	17	6	2	7	0	0	54	30	5	0	0	0	1	.457	.537	.652	1.189
15	White Sox	13	9/3/2022	CWS	vs	MIN	W 13-0	36	13	13	2	0	3	13	4	0	5	0	0	40	24	5	0	0	0	1	.361	.425	.667	1.092
16	Cardinals	13	8/18/2022	STL	vs	COL	W 13-0	38	13	15	3	0	2	13	5	0	7	1	0	43	24	5	0	0	0	1	.395	.465	.632	1.097
17	Dodgers	13	7/28/2022	LAD	@	COL	W 13-0	42	13	14	5	0	0	11	5	0	8	2	0	47	19	5	0	0	0	1	.333	.404	.452	.857
18	Cubs	13	7/22/2022	CHC	@	PHI	W 15-2	43	15	19	5	0	4	14	6	1	4	0	0	50	36	9	0	0	0	3	.442	.520	.837	1.357
19	Yankees	13	7/16/2022	NYY	vs	BOS	W 14-1	37	14	12	2	0	4	14	8	2	9	0	0	47	26	6	0	0	0	0	.324	.468	.703	1.171
20	Giants	13	7/12/2022	SFG	vs	ARI	W 13-0	38	13	14	3	1	4	12	3	0	10	0	0	41	31	8	0	0	0	0	.368	.415	.816	1.230
21	White Sox	13	6/15/2022	CWS	@	DET	W 13-0	46	13	22	4	1	3	13	3	2	11	0	0	51	37	8	0	0	0	3	.478	.529	.804	1.334
22	Yankees	13	6/3/2022	NYY	vs	DET	W 13-0	35	13	15	3	1	4	13	5	1	7	0	0	41	32	8	0	0	0	2	.429	.512	.914	1.426
23	Marlins	13	6/1/2022	MIA	@	COL	W 14-1	47	14	21	5	0	1	13	2	1	5	0	0	50	29	6	0	0	0	1	.447	.480	.617	1.097
24	Dodgers	13	5/26/2022	LAD	@	ARI	W 14-1	50	14	24	7	1	2	14	4	0	2	0	0	54	39	10	0	0	0	1	.480	.519	.780	1.299
25	Red Sox	13	5/24/2022	BOS	@	CWS	W 16-3	45	16	19	5	0	4	16	5	0	12	0	0	51	36	9	0	1	0	0	.422	.471	.800	1.271