Phil Niekro has allowed the most career runs by a starting pitcher, with 2,227 runs.

	NAME	R	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Phil Niekro P. Niekro	2,227	716	302	262	.535	716	3.37	3,181	245	45	0	5149.2	4,815	1,928	465	1,703	116	0	73	21,585	207	5.56	2.98	1.87	0.81	14.7	7.9	1.27	.270	3.89	8.42
2	Nolan Ryan N. Ryan	2,151	773	318	291	.522	773	3.18	5,654	222	61	0	5326.0	3,880	1,884	314	2,748	156	0	75	22,310	275	9.55	4.64	2.06	0.53	25.3	12.3	1.24	.265	3.63	6.56
3	Steve Carlton S. Carlton	2,096	709	327	240	.577	709	3.20	4,104	254	55	0	5165.1	4,616	1,835	405	1,814	53	0	145	21,457	177	7.15	3.16	2.26	0.71	19.1	8.5	1.24	.279	3.65	8.04
4	Don Sutton D. Sutton	2,095	756	321	253	.559	756	3.27	3,545	178	58	0	5248.1	4,670	1,905	469	1,333	81	0	96	21,500	110	6.08	2.29	2.66	0.80	16.5	6.2	1.14	.261	3.59	8.01
5	Gaylord Perry G. Perry	2,045	690	305	252	.548	690	3.10	3,372	303	53	0	5156.2	4,762	1,778	382	1,314	101	0	144	21,140	150	5.89	2.29	2.57	0.67	16.0	6.2	1.18	.274	3.57	8.31
6	Bert Blyleven B. Blyleven	2,021	685	286	248	.536	685	3.31	3,694	242	60	0	4957.1	4,614	1,823	428	1,316	155	0	67	20,429	114	6.71	2.39	2.81	0.78	18.1	6.4	1.20	.282	3.67	8.38
7	Jamie Moyer J. Moyer	2,020	638	262	206	.560	638	4.27	2,353	33	10	0	3947.1	4,107	1,872	509	1,104	142	0	64	16,812	52	5.36	2.52	2.13	1.16	14.0	6.6	1.32	.283	4.61	9.36
8	Red Ruffing R. Ruffing	2,016	538	264	212	.555	538	3.82	1,869	335	45	0	4132.2	4,094	1,755	249	1,463	51	0		17,623	44	4.07	3.19	1.28	0.54	10.6	8.3	1.34	.275	4.39	8.92
9	Tommy John T. John	1,981	700	284	228	.555	700	3.35	2,191	162	46	0	4622.1	4,699	1,718	295	1,223	98	0	99	19,321	178	4.27	2.38	1.79	0.57	11.3	6.3	1.28	.284	3.86	9.15
10	Early Wynn E. Wynn	1,981	611	287	232	.553	611	3.56	2,255	289	49	0	4398.2	4,135	1,742	330	1,713	62	0	32	18,704	50	4.61	3.50	1.32	0.68	12.1	9.2	1.33	.265	4.05	8.46
11	Greg Maddux G. Maddux	1,974	740	355	226	.611	740	3.15	3,366	109	35	0	5001.0	4,717	1,750	351	996	137	0	177	20,388	70	6.06	1.79	3.38	0.63	16.5	4.9	1.14	.281	3.55	8.49
12	Earl Whitehill E. Whitehill	1,956	473	206	179	.535	473	4.38	1,294	226	16	0	3443.1	3,794	1,674	191	1,375	93	0		15,240	41	3.38	3.59	0.94	0.50	8.5	9.0	1.50	.293	5.11	9.92
13	Warren Spahn W. Spahn	1,951	665	358	227	.612	665	3.08	2,501	382	63	0	5101.0	4,703	1,743	422	1,383	39	0	52	20,960	74	4.41	2.44	1.81	0.74	11.9	6.6	1.19	.258	3.44	8.30
14	Robin Roberts R. Roberts	1,915	609	275	240	.534	609	3.41	2,292	305	45	0	4567.1	4,467	1,733	498	872	54	0	63	18,724	32	4.52	1.72	2.63	0.98	12.2	4.7	1.17	.264	3.77	8.80
15	Tom Glavine T. Glavine	1,900	682	305	203	.600	682	3.54	2,607	56	25	0	4413.1	4,298	1,734	356	1,500	66	0	145	18,604	65	5.32	3.06	1.74	0.73	14.0	8.1	1.31	.280	3.87	8.76
16	Ted Lyons T. Lyons	1,900	484	245	210	.538	484	3.60	1,010	356	27	0	3907.0	4,196	1,564	208	1,027	30	0		16,676	48	2.33	2.37	0.98	0.48	6.1	6.2	1.34	.277	4.38	9.67
17	Burleigh Grimes B. Grimes	1,895	496	249	192	.565	496	3.54	1,402	314	35	0	3864.2	4,114	1,520	138	1,169	92	0		16,623	79	3.26	2.72	1.20	0.32	8.4	7.0	1.37	.288	4.41	9.58
18	Frank Tanana F. Tanana	1,893	616	236	236	.500	616	3.67	2,734	143	34	0	4136.1	4,019	1,688	445	1,227	128	0	110	17,413	114	5.95	2.67	2.23	0.97	15.7	7.0	1.27	.278	4.12	8.74
19	Roger Clemens R. Clemens	1,884	707	354	184	.658	707	3.12	4,671	118	46	0	4913.2	4,182	1,706	363	1,579	159	0	63	20,227	143	8.56	2.89	2.96	0.66	23.1	7.8	1.17	.284	3.45	7.66
20	Jim Kaat J. Kaat	1,850	625	260	217	.545	625	3.43	2,294	180	31	0	4137.2	4,203	1,579	366	955	115	0	77	17,336	116	4.99	2.08	2.40	0.80	13.2	5.5	1.25	.282	4.02	9.14
21	Eppa Rixey E. Rixey	1,849	554	247	239	.508	554	3.15	1,244	289	37	0	4171.2	4,335	1,462	84	982	71	0		17,427	84	2.68	2.12	1.27	0.18	7.1	5.6	1.27	.283	3.99	9.35
22	Bobo Newsom B. Newsom	1,797	483	196	207	.486	483	4.00	1,969	246	31	0	3524.2	3,544	1,566	189	1,598	51	0		15,438	50	5.03	4.08	1.23	0.48	12.8	10.4	1.46	.288	4.59	9.05
23	Sad Sam Jones S. Sam Jones	1,789	488	213	200	.516	488	3.80	1,122	250	36	0	3533.1	3,713	1,493	142	1,264	64	0		15,243	66	2.86	3.22	0.89	0.36	7.4	8.3	1.41	.282	4.56	9.46
24	Fergie Jenkins F. Jenkins	1,786	594	278	218	.560	594	3.32	3,082	267	49	0	4358.2	4,021	1,608	463	951	83	0	101	17,815	61	6.36	1.96	3.24	0.96	17.3	5.3	1.14	.269	3.69	8.30
25	Jack Morris J. Morris	1,779	527	251	182	.580	527	3.90	2,443	175	28	0	3746.1	3,501	1,624	383	1,356	56	0	94	15,791	201	5.87	3.26	1.80	0.92	15.5	8.6	1.30	.270	4.27	8.41