The Arizona Diamondbacks gave up their most runs in a game against the Dodgers on July 10, 2021, with 22 runs.

Interpreted as:

most runs allowed in a regular-season game by the diamondbacks

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Diamondbacks	22	7/10/2021	ARI	@	LAD	L 1-22	21.38	4	0	0	8.0	21	19	8	8	1	0	53	0	4.50	9.00	0.50	9.00	7.5	15.1	3.63	.406	24.75	23.63
2	Diamondbacks	21	10/2/2015	ARI	vs	HOU	L 5-21	16.00	8	0	0	9.0	19	16	4	8	0	1	57	1	8.00	8.00	1.00	4.00	14.0	14.0	3.00	.405	21.00	19.00
3	Diamondbacks	20	9/23/2003	ARI	@	COL	L 9-20	16.88	5	0	0	8.0	17	15	4	5	2	1	51	1	5.63	5.63	1.00	4.50	9.8	9.8	2.75	.371	22.50	19.13
4	Diamondbacks	19	7/11/2018	ARI	@	COL	L 2-19	21.38	4	0	0	8.0	19	19	5	6	0	0	49	0	4.50	6.75	0.67	5.63	8.2	12.2	3.13	.412	21.38	21.38
5	Diamondbacks	19	9/2/2002	ARI	vs	LAD	L 1-19	18.00	4	0	0	9.0	24	18	5	4	1	0	56	1	4.00	4.00	1.00	5.00	7.1	7.1	3.11	.452	19.00	24.00
6	Diamondbacks	19	6/18/2000	ARI	@	COL	L 2-19	21.38	9	0	0	8.0	23	19	4	2	0	0	49	2	10.13	2.25	4.50	4.50	18.4	4.1	3.13	.559	21.38	25.88
7	Diamondbacks	18	8/31/2022	ARI	vs	PHI	L 2-18	18.00	6	0	0	9.0	24	18	0	8	0	0	57	4	6.00	8.00	0.75	0.00	10.5	14.0	3.56	.558	18.00	24.00
8	Diamondbacks	18	3/30/2019	ARI	@	LAD	L 5-18	19.13	4	0	0	8.0	19	17	4	6	3	1	51	0	4.50	6.75	0.67	4.50	7.8	11.8	3.13	.441	20.25	21.38
9	Diamondbacks	18	8/24/2005	ARI	vs	NYM	L 4-18	18.00	3	0	0	9.0	20	18	5	7	1	1	53	2	3.00	7.00	0.43	5.00	5.7	13.2	3.00	.405	18.00	20.00
10	Diamondbacks	18	5/13/2005	ARI	@	COL	L 3-18	15.75	7	0	0	8.0	19	14	3	5	1	0	50	0	7.88	5.63	1.40	3.38	14.0	10.0	3.00	.471	20.25	21.38
11	Diamondbacks	18	9/3/2004	ARI	@	SFG	L 7-18	14.63	4	0	0	8.0	18	13	2	7	3	2	55	1	4.50	7.88	0.57	2.25	7.3	12.7	3.13	.410	20.25	20.25
12	Diamondbacks	17	5/14/2021	ARI	vs	WSH	L 2-17	16.00	5	0	0	9.0	22	16	3	5	2	0	59	1	5.00	5.00	1.00	3.00	8.5	8.5	3.00	.432	17.00	22.00
13	Diamondbacks	17	5/8/2010	ARI	vs	MIL	L 3-17	12.00	11	0	0	9.0	17	12	2	7	0	0	53	0	11.00	7.00	1.57	2.00	20.8	13.2	2.67	.455	17.00	17.00
14	Diamondbacks	17	8/19/2005	ARI	@	CIN	L 3-17	19.13	7	0	0	8.0	15	17	4	9	2	1	49	0	7.88	10.13	0.78	4.50	14.3	18.4	3.00	.407	19.13	16.88
15	Diamondbacks	16	8/20/2022	ARI	vs	STL	L 7-16	15.00	6	0	0	9.0	18	15	4	5	0	0	49	0	6.00	5.00	1.20	4.00	12.2	10.2	2.56	.412	16.00	18.00
16	Diamondbacks	16	8/1/2017	ARI	@	CHC	L 4-16	15.75	6	0	0	8.0	17	14	5	4	0	0	45	0	6.75	4.50	1.50	5.63	13.3	8.9	2.63	.400	18.00	19.13
17	Diamondbacks	16	8/14/2016	ARI	@	BOS	L 2-16	16.88	7	0	0	8.0	19	15	4	4	0	0	48	0	7.88	4.50	1.75	4.50	14.6	8.3	2.88	.455	18.00	21.38
18	Diamondbacks	16	5/8/2005	ARI	vs	PIT	L 2-16	16.00	4	0	0	9.0	17	16	3	6	0	0	50	0	4.00	6.00	0.67	3.00	8.0	12.0	2.56	.378	16.00	17.00
19	Diamondbacks	16	4/4/2005	ARI	vs	CHC	L 6-16	14.00	8	0	0	9.0	23	14	2	2	0	0	51	1	8.00	2.00	4.00	2.00	15.7	3.9	2.78	.538	16.00	23.00
20	Diamondbacks	16	8/21/2000	ARI	vs	MIL	L 8-16	13.00	10	0	0	9.0	19	13	4	5	0	2	51	0	10.00	5.00	2.00	4.00	19.6	9.8	2.67	.469	16.00	19.00
21	Diamondbacks	16	6/23/1998	ARI	@	TEX	L 5-16	12.38	6	0	0	8.0	19	11	3	0	1	0	44	1	6.75	0.00		3.38	13.6	0.0	2.38	.471	18.00	21.38
22	Diamondbacks	15	9/14/2024	ARI	vs	MIL	L 8-15	15.00	4	0	0	9.0	16	15	4	7	0	0	49	0	4.00	7.00	0.57	4.00	8.2	14.3	2.56	.353	15.00	16.00
23	Diamondbacks	15	6/13/2023	ARI	vs	PHI	L 3-15	13.00	6	0	0	9.0	20	13	2	5	0	0	50	0	6.00	5.00	1.20	2.00	12.0	10.0	2.78	.486	15.00	20.00
24	Diamondbacks	15	6/16/2019	ARI	@	WSH	L 5-15	16.88	8	0	0	8.0	15	15	4	5	1	0	43	0	9.00	5.63	1.60	4.50	18.6	11.6	2.50	.440	16.88	16.88
25	Diamondbacks	15	8/6/2016	ARI	vs	MIL	L 6-15	15.00	9	0	0	9.0	19	15	2	10	1	1	56	2	9.00	10.00	0.90	2.00	16.1	17.9	3.22	.500	15.00	19.00