The St. Louis Cardinals had the most runs by a team in a game in 1926, with 23 runs against the Phillies on September 16, 1926.

Interpreted as:

most runs by a team in a regular-season game in 1926

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	AVG	OBP	SLG	OPS
1	Cardinals	23	9/16/1926	SLN	@	PHN	W 23-3	49	22	5	0	0	18	8	0	5	5	0	57	27	5	0	.449	.526	.551	1.077
2	Reds	21	8/11/1926	CIN	@	PHN	W 21-3	50	21	3	0	3	20	6	0	3	0	0	56	33	6	0	.420	.482	.660	1.142
3	White Sox	19	8/31/1926	CWS	@	DET	W 19-2	50	23	5	0	0	19	10	1	3	3	0	61	28	5	0	.460	.557	.560	1.117
4	Braves	19	7/11/1926	BSN	@	SLN	W 19-5	50	23	6	0	0	17	3	0	1	0	0	54	29	6	1	.460	.491	.580	1.071
5	Senators	19	7/10/1926	WSH	vs	SLA	W 19-4	40	19	4	2	0	16	7	0	2	3	1	48	27	6	1	.475	.553	.675	1.228
6	Cardinals	18	7/10/1926	SLN	vs	BSN	W 18-6	38	16	2	3	1	15	8	0	4	0	0	51	27	6	5	.421	.522	.711	1.232
7	Cubs	18	4/23/1926	CHC	vs	CIN	W 18-1	43	20	7	1	0	17	4	1	3	2	0	51	29	8	3	.465	.521	.674	1.195
8	Yankees	18	4/20/1926	NYY	@	WSH	W 18-5	46	22	4	0	1	17	7	1	7	1	1	56	29	5	2	.478	.556	.630	1.186
9	Giants	17	9/3/1926	NYG	vs	BSN	W 17-3	43	23	2	0	1	16	4	0	4	2	0	47	28	3	0	.535	.574	.651	1.226
10	Athletics	17	7/10/1926	PHA	vs	CWS	W 17-14	40	19	5	1	1	17	8	2	3	0	1	51	29	7	1	.475	.580	.725	1.305
11	Senators	17	5/25/1926	WSH	@	PHA	W 17-12	43	16	4	1	0	13	6	0	7	2	0	49	22	5	0	.372	.449	.512	.961
12	Cubs	16	7/20/1926	CHC	vs	NYG	W 16-2	41	18	4	0	1	14	4	0	4	1	0	45	25	5	0	.439	.489	.610	1.099
13	Reds	16	6/27/1926	CIN	vs	PIT	W 16-0	39	18	5	5	1	15	5	0	1	0	0	48	36	11	4	.462	.523	.923	1.446
14	Reds	16	4/29/1926	CIN	@	PIT	W 16-9	41	17	4	0	0	15	9	0	1	0	0	52	21	4	2	.415	.520	.512	1.032
15	Cardinals	15	9/22/1926	SLN	@	BKN	W 15-7	40	17	3	5	2	13	5	0	2	1	0	48	36	10	3	.425	.489	.900	1.389
16	Pirates	15	8/26/1926	PIT	vs	NYG	W 15-7	42	21	3	2	0	13	4	1	5	0	0	48	28	5	1	.500	.553	.667	1.220
17	Giants	15	6/6/1926	NYG	vs	CHC	W 15-3	38	17	2	1	2	13	7	0	2	0	0	46	27	5	1	.447	.533	.711	1.244
18	Indians	15	6/5/1926	CLE	vs	NYY	W 15-3	38	19	4	0	2	14	3	1	0	1	1	46	29	6	4	.500	.548	.763	1.311
19	Phillies	15	4/17/1926	PHN	vs	BKN	W 15-3	39	16	2	1	0	11	6	3	1	0	0	51	20	3	3	.410	.521	.513	1.034
20	Yankees	14	9/21/1926	NYY	@	CWS	W 14-0	42	16	2	1	2	12	8	0	1	3	0	53	26	5	3	.381	.480	.619	1.099
21	Indians	14	9/12/1926	CLE	vs	WSH	W 14-4	40	16	6	1	0	14	4	0	1	1	1	45	24	7	1	.400	.455	.600	1.055
22	Senators	14	9/1/1926	WSH	@	BSA	W 14-12	37	17	4	1	0	14	4	1	3	3	0	49	23	5	7	.459	.524	.622	1.145
23	Braves	14	8/4/1926	BSN	vs	PIT	W 14-0	41	19	2	2	0	12	2	0	1	1	0	46	25	4	3	.463	.488	.610	1.098
24	Pirates	14	8/3/1926	PIT	@	PHN	W 14-2	46	22	8	0	3	13	3	0	2	1	0	50	39	11	1	.478	.510	.848	1.358
25	Senators	14	8/2/1926	WSH	@	SLA	W 14-11	36	13	0	0	2	11	7	1	4	1	1	45	19	2	1	.361	.477	.528	1.005