The Houston Astros had the most runs by a team in October 2021, with 110 runs.

	TEAM	R	MONTH	G	W%	W	L	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Astros	110	October 2021	18	.611	11	7	626	174	28	4	24	107	63	8	150	12	0	705	282	56	3	5	7	11	.278	.349	.450	.799
2	Red Sox	76	October 2021	14	.643	9	5	495	132	19	3	28	75	54	3	120	3	1	556	241	50	3	1	0	16	.267	.342	.487	.829
3	Dodgers	74	October 2021	15	.600	9	6	498	127	20	0	22	73	48	4	119	17	0	556	213	42	3	3	6	10	.255	.324	.428	.751
4	Braves	72	October 2021	18	.667	12	6	595	148	24	2	25	71	53	5	179	7	1	656	251	51	1	2	5	9	.249	.315	.422	.736
5	Rays	36	October 2021	7	.429	3	4	256	63	14	1	13	35	23	1	78	8	1	280	118	28	0	0	1	4	.246	.311	.461	.772
6	White Sox	33	October 2021	7	.429	3	4	243	70	11	0	6	33	23	5	64	0	1	273	99	17	0	2	0	8	.288	.359	.407	.766
7	Blue Jays	28	October 2021	3	1.000	3	0	109	38	8	0	11	28	6	2	13	1	0	117	79	19	0	0	0	1	.349	.393	.725	1.118
8	Giants	26	October 2021	8	.500	4	4	257	50	8	0	8	26	16	1	74	0	0	277	82	16	0	3	0	1	.195	.242	.319	.561
9	Diamondbacks	23	October 2021	3	.667	2	1	110	34	11	1	4	22	10	0	22	2	2	120	59	16	0	0	1	0	.309	.367	.536	.903
10	Pirates	20	October 2021	3	.667	2	1	106	37	4	3	2	19	12	1	31	1	1	119	53	9	0	0	1	4	.349	.420	.500	.920
11	Athletics	18	October 2021	3	.333	1	2	107	27	3	1	6	17	8	2	26	3	0	118	50	10	0	1	0	0	.252	.314	.467	.781
12	Brewers	18	October 2021	7	.143	1	6	228	46	14	0	3	18	14	4	81	5	1	247	69	17	1	0	0	4	.202	.260	.303	.563
13	Indians	17	October 2021	3	.667	2	1	103	22	3	0	3	14	8	3	26	6	1	114	34	6	0	0	0	1	.214	.289	.330	.620
14	Twins	17	October 2021	3	.667	2	1	108	31	6	0	4	16	3	1	22	0	0	113	49	10	0	1	0	3	.287	.310	.454	.763
15	Rockies	15	October 2021	3	.333	1	2	106	28	4	1	4	14	8	0	29	2	0	115	46	9	1	0	0	3	.264	.316	.434	.750
16	Reds	14	October 2021	3	.333	1	2	101	25	8	1	4	14	10	2	30	0	1	115	47	13	1	1	0	2	.248	.325	.465	.790
17	Royals	14	October 2021	3	.333	1	2	100	27	6	0	1	12	10	3	25	3	2	113	36	7	0	0	0	1	.270	.354	.360	.714
18	Angels	13	October 2021	3	.667	2	1	98	22	4	1	4	13	12	1	28	3	0	114	40	9	2	1	3	2	.224	.313	.408	.721
19	Rangers	13	October 2021	3	.333	1	2	98	23	2	0	5	13	8	0	17	0	1	106	40	7	0	0	0	2	.235	.292	.408	.701
20	Cubs	12	October 2021	3	.667	2	1	93	23	4	0	3	12	12	1	23	3	1	106	36	7	0	0	0	4	.247	.340	.387	.727
21	Cardinals	12	October 2021	4	.250	1	3	124	28	3	1	4	10	15	4	31	7	1	145	45	8	2	0	1	3	.226	.329	.363	.692
22	Phillies	10	October 2021	3	.333	1	2	99	23	4	0	4	10	5	4	40	1	0	110	39	8	1	1	0	1	.232	.294	.394	.688
23	Tigers	10	October 2021	3	.333	1	2	99	23	4	2	1	10	10	0	31	9	0	111	34	7	0	2	0	3	.232	.297	.343	.641
24	Nationals	10	October 2021	3	.000	0	3	99	21	8	0	3	10	17	0	34	0	0	117	38	11	0	1	2	1	.212	.325	.384	.709
25	Mariners	10	October 2021	3	.333	1	2	98	22	7	1	1	10	12	3	26	1	0	114	34	9	1	0	1	2	.224	.327	.347	.674