Antonio Senzatela and Zac Gallen are tied for allowing the most runs this season, with 60 runs.

Interpreted as:

most runs given up by a player this regular season

	NAME	R	SEASON	TM	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Antonio Senzatela A. Senzatela	60	2025	COL	15	2	10	.167	14	6.72	35	0	0	0	71.0	113	53	12	27	1	0	0	345	7	4.44	3.42	1.30	1.52	10.1	7.8	1.97	.374	7.61	146	5.46	130	14.32	-9.3
2	Zac Gallen Z. Gallen	60	2025	AZ	16	5	8	.385	16	5.60	86	0	0	0	91.2	87	57	17	41	2	0	1	399	1	8.44	4.03	2.10	1.67	21.6	10.3	1.40	.277	5.89	136	5.01	129	8.54	-11.9
3	Germán Márquez G. Márquez	56	2025	COL	15	3	8	.273	15	6.11	50	0	0	0	73.2	97	50	7	24	5	0	0	341	4	6.11	2.93	2.08	0.86	14.7	7.0	1.64	.353	6.84	133	4.13	98	11.85	0.8
4	Kyle Freeland K. Freeland	54	2025	COL	14	1	8	.111	14	5.13	57	0	0	0	73.2	98	42	8	15	2	0	1	328	1	6.96	1.83	3.80	0.98	17.4	4.6	1.53	.366	6.60	111	3.62	86	11.97	4.7
5	Sandy Alcantara S. Alcantara	53	2025	MIA	14	3	8	.273	14	6.88	55	0	0	0	68.0	68	52	10	32	2	0	0	304	4	7.28	4.24	1.72	1.32	18.1	10.5	1.47	.283	7.01	165	4.86	121	9.00	-6.5
6	Taj Bradley T. Bradley	52	2025	TBR	15	4	5	.444	15	4.95	73	0	0	0	80.0	74	44	12	34	4	0	0	343	0	8.21	3.83	2.15	1.35	21.3	9.9	1.35	.282	5.85	129	4.62	117	8.33	-6.3
7	Luis Severino L. Severino	50	2025	ATH	16	2	7	.222	16	4.42	66	0	0	0	95.2	98	47	7	30	5	0	1	416	1	6.21	2.82	2.20	0.66	15.9	7.2	1.34	.295	4.70	111	3.74	92	9.22	3.5
8	Jeffrey Springs J. Springs	50	2025	ATH	16	6	5	.545	14	4.24	72	0	0	0	87.0	75	41	13	32	1	0	0	369	0	7.45	3.31	2.25	1.34	19.5	8.7	1.23	.247	5.17	106	4.49	111	7.76	-4.2
9	Trevor Williams T. Williams	48	2025	WSH	15	3	8	.273	15	5.54	58	0	0	0	74.2	90	46	8	18	2	0	0	330	1	6.99	2.17	3.22	0.96	17.6	5.5	1.45	.336	5.79	137	3.71	92	10.85	2.8
10	Eduardo Rodriguez E. Rodriguez	47	2025	AZ	12	2	4	.333	12	5.93	64	0	0	0	60.2	76	40	11	22	0	0	1	280	2	9.49	3.26	2.91	1.63	22.9	7.9	1.62	.355	6.97	144	4.40	113	11.27	-3.7
11	Dean Kremer D. Kremer	47	2025	BAL	15	6	7	.462	14	4.80	65	0	0	0	84.1	92	45	12	23	1	0	0	361	5	6.94	2.45	2.83	1.28	18.0	6.4	1.36	.308	5.02	123	4.23	106	9.82	-2.4
12	Ben Brown B. Brown	47	2025	CHC	15	4	5	.444	13	5.57	88	0	0	0	74.1	85	46	9	25	4	0	0	334	1	10.65	3.03	3.52	1.09	26.3	7.5	1.48	.365	5.69	141	3.44	88	10.29	4
13	Jack Kochanowicz J. Kochanowicz	47	2025	LAA	15	3	8	.273	15	5.38	58	0	0	0	77.0	83	46	15	36	5	0	2	337	3	6.78	4.21	1.61	1.75	17.2	10.7	1.55	.305	5.49	132	5.69	136	9.70	-12.4
14	Brandon Pfaadt B. Pfaadt	47	2025	AZ	15	8	4	.667	15	5.38	58	0	0	0	75.1	86	45	15	19	9	0	1	333	2	6.93	2.27	3.05	1.79	17.4	5.7	1.39	.306	5.62	131	5.23	135	10.27	-11.7
15	Michael Lorenzen M. Lorenzen	46	2025	KCR	15	4	7	.364	15	4.81	69	0	0	0	82.1	85	44	14	28	2	0	0	357	10	7.54	3.06	2.46	1.53	19.3	7.8	1.37	.291	5.03	115	4.70	116	9.29	-5.8
16	Bowden Francis B. Francis	46	2025	TOR	14	2	8	.200	14	6.05	54	0	0	0	64.0	71	43	19	27	6	0	0	288	3	7.59	3.80	2.00	2.67	18.8	9.4	1.53	.286	6.47	153	6.79	167	9.98	-19.4
17	JP Sears	46	2025	ATH	15	5	6	.455	15	5.45	58	0	0	0	76.0	82	46	18	17	5	0	0	328	1	6.87	2.01	3.41	2.13	17.7	5.2	1.30	.278	5.45	136	5.49	135	9.71	-12
18	Tyler Anderson T. Anderson	45	2025	LAA	15	2	5	.286	15	4.56	65	0	0	0	81.0	82	41	15	31	3	0	3	357	5	7.22	3.44	2.10	1.67	18.2	8.7	1.40	.276	5.00	112	5.13	123	9.11	-8.2
19	Kevin Gausman K. Gausman	45	2025	TOR	15	5	6	.455	15	4.60	84	0	0	0	86.0	73	44	12	24	2	0	1	348	0	8.79	2.51	3.50	1.26	24.1	6.9	1.13	.270	4.71	117	3.84	94	7.64	2.2
20	Mitchell Parker M. Parker	45	2025	WSH	15	4	8	.333	15	4.59	58	0	0	0	80.1	75	41	9	31	3	0	0	344	2	6.50	3.47	1.87	1.01	16.9	9.0	1.32	.272	5.04	114	4.35	107	8.40	-2.6
21	Dylan Cease D. Cease	44	2025	SDP	15	2	6	.250	15	4.69	105	0	0	0	80.2	77	42	8	30	2	0	1	346	2	11.71	3.35	3.50	0.89	30.3	8.7	1.33	.343	4.91	120	2.94	74	8.59	9.2
22	Charlie Morton C. Morton	44	2025	BAL	17	4	7	.364	11	5.64	74	0	0	0	67.0	75	42	10	32	5	1	0	308	1	9.94	4.30	2.31	1.34	24.0	10.4	1.60	.348	5.91	144	4.46	112	10.07	-3.7
23	Jesús Luzardo J. Luzardo	44	2025	PHI	15	6	3	.667	15	4.41	97	0	0	0	83.2	92	41	7	28	1	0	0	361	1	10.43	3.01	3.46	0.75	26.9	7.8	1.43	.373	4.73	108	2.88	70	9.90	11.1
24	Shane Baz S. Baz	44	2025	TBR	15	7	3	.700	15	4.79	77	0	0	0	82.2	76	44	14	34	5	0	0	352	0	8.38	3.70	2.26	1.52	21.9	9.7	1.33	.279	4.79	125	4.82	122	8.27	-8.4
25	Sean Burke S. Burke	44	2025	CWS	15	3	7	.300	13	4.50	61	0	0	0	76.0	73	38	11	35	4	0	0	333	2	7.22	4.14	1.74	1.30	18.3	10.5	1.42	.279	5.21	112	4.88	117	8.64	-5.6