Between the 1878 and 2022 seasons, the Chicago Cubs had the most runs by a team, with 99,875 runs.

	TEAM	R	G	W%	W	L	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	99,875	21,805	.512	11,083	10,562	745,607	195,183	32,934	7,226	14,810	86,531	67,146	5,124	101,919	15,449	2,996	833,665	286,999	54,970	12,989	2,799	3,485	9,758	.262	.326	.385	.711
2	Giants	99,084	21,399	.536	11,382	9,854	730,562	192,492	30,753	6,987	15,187	88,622	67,098	5,529	96,227	16,366	3,096	817,737	282,780	52,927	11,631	2,917	3,980	9,924	.263	.329	.387	.716
3	Braves	96,776	21,762	.502	10,840	10,769	744,516	193,288	31,289	6,196	14,472	84,782	66,194	4,928	96,996	13,866	3,011	831,094	280,385	51,957	12,668	2,788	3,620	10,106	.260	.323	.377	.700
4	Reds	96,508	21,515	.504	10,775	10,601	733,319	191,308	31,778	7,488	13,900	85,733	65,487	5,309	98,889	17,717	3,298	819,861	279,762	53,166	12,622	2,956	3,627	9,503	.261	.325	.382	.706
5	Dodgers	95,896	21,315	.531	11,234	9,942	726,272	189,793	30,381	6,951	13,573	86,183	67,476	4,984	97,261	17,068	3,493	814,488	274,795	50,905	12,756	2,924	3,664	9,711	.261	.327	.378	.706
6	Pirates	95,659	21,474	.501	10,687	10,647	735,833	194,027	31,773	8,879	11,900	85,223	63,112	5,394	96,213	15,410	3,198	819,994	279,258	52,552	12,515	3,017	3,668	9,818	.264	.325	.380	.705
7	Phillies	94,533	21,324	.473	10,022	11,187	729,658	190,047	32,765	6,618	13,724	84,827	66,513	5,266	102,117	14,629	2,849	816,244	277,220	53,107	11,886	2,921	3,690	9,614	.260	.326	.380	.705
8	Yankees	90,879	18,690	.570	10,602	8,000	637,277	169,498	28,086	5,457	16,785	84,385	67,170	4,808	91,668	11,429	2,734	721,999	258,853	50,328	9,571	3,173	2,778	10,397	.266	.339	.406	.745
9	Cardinals	90,793	20,282	.514	10,351	9,800	693,838	184,581	31,217	7,015	12,441	82,922	62,980	5,053	95,144	14,790	3,547	776,852	267,151	50,673	11,938	3,043	3,740	9,885	.266	.330	.385	.715
10	Red Sox	88,609	18,977	.518	9,796	9,098	649,422	173,445	32,380	5,543	14,167	82,120	65,665	4,640	92,183	9,329	2,469	733,555	259,412	52,090	10,574	3,254	2,942	11,297	.267	.337	.399	.737
11	Tigers	87,427	19,012	.503	9,512	9,407	648,474	171,662	29,028	6,212	14,193	80,444	64,402	4,325	93,367	11,111	2,886	731,211	255,693	49,433	10,988	3,022	2,421	10,489	.265	.334	.394	.728
12	Guardians	85,963	18,989	.512	9,684	9,214	647,469	171,676	30,544	5,447	13,558	79,417	61,537	4,675	91,890	11,576	3,294	728,356	253,788	49,549	11,426	3,249	2,469	10,281	.265	.332	.392	.724
13	Athletics	83,853	18,951	.488	9,210	9,654	642,578	165,718	28,656	5,286	13,714	77,210	63,374	4,586	95,658	11,837	3,143	724,190	246,088	47,656	10,632	3,020	2,244	10,344	.258	.327	.383	.710
14	Twins	83,458	18,999	.481	9,090	9,800	648,232	170,227	29,105	6,280	11,555	76,781	61,158	4,939	91,124	11,837	3,029	727,572	246,557	46,940	10,167	3,076	2,632	10,708	.263	.329	.380	.710
15	White Sox	82,763	18,985	.503	9,492	9,390	642,972	167,341	27,652	5,527	11,945	76,022	61,170	5,142	88,841	13,411	3,420	724,767	241,882	45,124	12,329	3,154	2,433	10,254	.260	.328	.376	.704
16	Orioles	81,823	18,990	.473	8,928	9,952	645,032	166,546	28,692	4,844	13,961	75,582	62,154	4,345	95,204	10,310	2,723	725,031	246,809	47,497	10,503	2,997	2,544	10,621	.258	.326	.383	.709
17	Rangers	44,046	9,802	.475	4,650	5,146	334,690	86,455	15,359	1,854	9,738	41,594	31,678	2,575	62,094	5,727	2,792	374,630	134,736	26,951	2,945	2,742	2,211	7,570	.258	.325	.403	.727
18	Angels	42,510	9,815	.498	4,885	4,927	333,193	85,501	14,747	1,764	8,753	39,984	31,201	2,639	59,342	5,820	3,012	373,226	130,035	25,264	3,514	2,679	2,447	7,615	.257	.323	.390	.713
19	Astros	40,999	9,656	.501	4,831	4,820	327,589	83,458	15,295	2,129	7,969	38,558	31,207	2,741	60,139	6,925	3,067	368,149	126,918	25,393	3,996	2,616	3,094	7,116	.255	.322	.387	.710
20	Mets	39,641	9,648	.483	4,652	4,988	326,536	81,680	14,550	1,770	8,104	37,293	31,197	2,633	61,877	5,627	2,692	366,851	124,082	24,424	3,957	2,528	3,109	7,208	.250	.318	.380	.698
21	Brewers	37,800	8,518	.484	4,123	4,391	289,317	74,244	13,832	1,702	8,323	35,809	27,690	2,586	55,656	5,576	2,647	325,053	116,449	23,857	3,129	2,331	2,118	6,344	.257	.325	.402	.727
22	Royals	37,262	8,509	.478	4,066	4,441	291,318	76,713	14,309	2,202	6,639	35,129	25,037	2,320	49,231	6,753	2,802	323,538	115,343	23,150	2,322	2,541	1,826	6,566	.263	.324	.396	.720
23	Nationals	35,660	8,514	.484	4,123	4,387	288,047	73,165	14,091	1,738	7,269	33,506	27,235	2,453	54,431	6,150	2,659	323,756	112,539	23,098	3,824	2,197	2,863	6,247	.254	.321	.391	.712
24	Padres	34,334	8,522	.464	3,952	4,568	288,145	71,798	12,664	1,722	6,823	32,268	27,358	2,000	56,757	5,711	2,534	323,312	108,375	21,209	3,650	2,159	2,647	6,203	.249	.316	.376	.693
25	Blue Jays	33,522	7,228	.498	3,598	3,627	247,803	64,585	12,878	1,445	7,872	31,793	22,930	2,260	46,089	4,373	1,904	276,499	103,969	22,195	1,473	2,033	1,361	5,638	.261	.326	.420	.746