The Detroit Tigers had their most runs in a game 4 times, with 21 runs.

Interpreted as:

most runs scored regular-season game by the tigers

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Tigers	21	7/1/1936	DET	@	CWS	W 21-6	53	25	2	1	1	19	6	0	2	1	1	60	32	4	1				.472	.525	.604	1.129
2	Tigers	21	7/25/1920	DET	vs	SLA	W 21-8	46	22	2	3	0	20	6	0	2	1	0	52	30	5	0				.478	.538	.652	1.191
3	Tigers	21	7/17/1908	DET	@	PHA	W 21-2	50	27	9	3	0	18	7	0	8	5		59	42	12	2				.540	.596	.840	1.436
4	Tigers	21	9/15/1901	DET	vs	CLE	W 21-0	42	24	8	0	1	20	3	2	1	1	-10	49	35	9	2		-10	-10	.571	.617	.833	1.450
5	Tigers	20	4/17/1993	DET	vs	SEA	W 20-3	43	20	2	1	2	20	10	1	7	3	1	54	30	5	0	0	1	0	.465	.574	.698	1.272
6	Tigers	20	4/13/1993	DET	vs	OAK	W 20-4	43	18	2	0	3	18	12	1	10	1	0	56	29	5	0	0	0	0	.419	.554	.674	1.228
7	Tigers	20	8/14/1937	DET	vs	SLA	W 20-7	45	22	5	0	6	19	5	1	1	0	0	52	45	11	1				.489	.549	1.000	1.549
8	Tigers	20	6/5/1934	DET	vs	CLE	W 20-2	45	21	9	1	1	18	2	1	4	2	1	49	35	11	1				.467	.500	.778	1.278
9	Tigers	20	7/7/1928	DET	@	BSA	W 20-8	43	18	4	0	0	17	9	0	2	5	0	54	22	4	2				.419	.519	.512	1.031
10	Tigers	20	9/5/1924	DET	vs	CLE	W 20-1	42	21	3	2	0	20	5	1	4	4	1	51	28	5	3				.500	.563	.667	1.229
11	Tigers	19	4/25/2017	DET	vs	SEA	W 19-9	48	24	5	1	4	18	7	0	5	0	0	55	43	10	0	0	1	0	.500	.564	.896	1.459
12	Tigers	19	7/21/2008	DET	@	KCR	W 19-4	45	18	3	1	2	17	9	0	9	0	0	54	29	6	0	0	0	0	.400	.500	.644	1.144
13	Tigers	19	5/24/2008	DET	vs	MIN	W 19-3	42	17	3	0	2	17	5	0	5	0	0	48	26	5	1	0	0	0	.405	.468	.619	1.087
14	Tigers	19	4/23/2008	DET	vs	TEX	W 19-6	36	14	2	0	2	18	10	2	4	1	0	51	22	4	1	2	0	0	.389	.520	.611	1.131
15	Tigers	19	8/8/2001	DET	@	TEX	W 19-6	47	21	4	1	5	19	5	1	5	1	0	54	42	10	0	1	1	0	.447	.500	.894	1.394
16	Tigers	19	9/29/1928	DET	vs	NYY	W 19-10	49	27	3	2	2	18	3	1	2	2	1	54	40	7	1				.551	.585	.816	1.401
17	Tigers	19	6/17/1925	DET	@	NYY	W 19-1	44	18	2	2	2	14	7	0	2	0	1	52	30	6	1				.409	.490	.682	1.172
18	Tigers	19	6/29/1917	DET	@	SLA	W 19-1	41	19	2	2	2		9	0	4	4		54	31	6	4				.463	.560	.756	1.316
19	Tigers	19	5/18/1902	DET	vs	CLE	W 19-11	34	16	3	1	2	18	7	2	2	1	-12	44	27	6	1		-12	-12	.471	.581	.794	1.376
20	Tigers	19	7/13/1901	DET	vs	CLE	W 19-12	42	17	2	1	0	12	9	3	0	2	-10	54	21	3	0		-10	-10	.405	.537	.500	1.037
21	Tigers	18	9/4/2011	DET	vs	CWS	W 18-2	48	24	5	0	2	17	3	1	12	0	0	52	35	7	0	0	0	0	.500	.538	.729	1.268
22	Tigers	18	4/29/2006	DET	vs	MIN	W 18-1	48	23	6	0	4	15	2	1	10	1	0	51	41	10	0	0	0	0	.479	.510	.854	1.364
23	Tigers	18	5/18/2001	DET	@	TBD	W 18-2	46	19	3	2	1	18	4	1	10	2	0	52	29	6	0	1	0	1	.413	.462	.630	1.092
24	Tigers	18	6/20/2000	DET	@	TOR	W 18-6	41	18	3	1	8	18	9	0	3	0	0	50	47	12	0	0	0	4	.439	.540	1.146	1.686
25	Tigers	18	8/14/1988	DET	@	BOS	W 18-6	42	19	4	0	2	18	8	0	2	0	0	52	29	6	0	2	0	2	.452	.519	.690	1.210