most runs scored in a game by a team against the guardians

The Boston Red Sox have scored the most runs by a team in a game versus the Cleveland Indians, with 24 runs on August 21, 1986.

Interpreted as:

most runs scored in a regular-season game by a team against the guardians

	TEAM	R	DATE	TM		OPP	RESULT	AB	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Red Sox	24	8/21/1986	BOS	@	CLE	W 24-5	51	24	2	0	3	23	9	1	2	0	0	61	35	5	0	0	0	0	.471	.557	.686	1.244
2	Twins	23	6/4/2002	MIN	vs	CLE	W 23-2	50	25	6	1	3	22	7	0	4	0	0	57	42	10	0	0	1	0	.500	.561	.840	1.401
3	Angels	21	4/30/2002	ANA	@	CLE	W 21-2	49	22	2	0	3	18	7	2	4	3	0	59	33	5	0	1	1	0	.449	.525	.673	1.199
4	Yankees	21	7/24/1999	NYY	vs	CLE	W 21-1	44	21	5	0	2	21	9	0	7	0	0	54	32	7	0	1	1	0	.477	.556	.727	1.283
5	Athletics	21	7/25/1929	PHA	vs	CLE	W 21-3	46	25	6	0	4	20	4	0	0	4	0	52	43	10	2				.543	.580	.935	1.515
6	Yankees	21	9/25/1921	NYY	vs	CLE	W 21-7	44	20	1	2	2	19	8	0	3	1	0	52	31	5	0				.455	.538	.705	1.243
7	Highlanders	21	7/14/1904	NYH	vs	CLE	W 21-3	50	21	4	2	2	15	1	0	3	2		52	35	8	1				.420	.431	.700	1.131
8	Tigers	21	9/15/1901	DET	vs	CLE	W 21-0	42	24	8	0	1	20	3	2	1	1	-10	49	35	9	2		-10	-10	.571	.617	.833	1.450
9	Twins	20	9/4/2023	MIN	@	CLE	W 20-6	46	20	2	0	6	20	6	0	4	0	0	53	40	8	0	1	0	0	.435	.491	.870	1.360
10	Tigers	20	6/5/1934	DET	vs	CLE	W 20-2	45	21	9	1	1	18	2	1	4	2	1	49	35	11	1				.467	.500	.778	1.278
11	White Sox	20	4/30/1934	CWS	vs	CLE	W 20-10	42	18	5	1	4	18	6	1	2	1	0	51	37	10	2				.429	.510	.881	1.391
12	Tigers	20	9/5/1924	DET	vs	CLE	W 20-1	42	21	3	2	0	20	5	1	4	4	1	51	28	5	3				.500	.563	.667	1.229
13	Senators	20	8/24/1923	WSH	@	CLE	W 20-8	42	22	6	3	0	18	14	0	0	3	2	59	34	9	3				.524	.643	.810	1.452
14	White Sox	19	9/2/2001	CWS	vs	CLE	W 19-10	40	17	3	0	3	18	9	1	6	0	0	50	29	6	0	0	0	1	.425	.540	.725	1.265
15	Rangers	19	5/12/1986	TEX	@	CLE	W 19-2	43	22	3	0	1	18	9	1	5	0	3	55	28	4	1	1	0	2	.512	.593	.651	1.244
16	Orioles	19	8/28/1957	BAL	@	CLE	W 19-6	46	19	7	1	3	18	7	0	8	1	0	54	37	11	1	0	1	1	.413	.491	.804	1.295
17	Yankees	19	7/14/1931	NYY	vs	CLE	W 19-2	40	19	2	1	4	19	12	0	4	3	1	53	35	7	1				.475	.596	.875	1.471
18	Senators	19	7/18/1925	WSH	@	CLE	W 19-6	44	24	5	3	1	18	3	1	2	3	1	52	38	9	4				.545	.583	.864	1.447
19	Senators	19	7/27/1920	WSH	@	CLE	W 19-6	48	22	2	0	0	16	7	0	7	3	0	56	24	2	1				.458	.527	.500	1.027
20	Yankees	19	6/18/1916	NYY	@	CLE	W 19-3	43	19	5	1	1	17	6	2	5	2		54	29	7	3				.442	.529	.674	1.204
21	Tigers	19	5/18/1902	DET	vs	CLE	W 19-11	34	16	3	1	2	18	7	2	2	1	-12	44	27	6	1		-12	-12	.471	.581	.794	1.376
22	Tigers	19	7/13/1901	DET	vs	CLE	W 19-12	42	17	2	1	0	12	9	3	0	2	-10	54	21	3	0		-10	-10	.405	.537	.500	1.037
23	Orioles	18	6/6/2021	BAL	vs	CLE	W 18-5	43	21	3	0	2	16	3	1	6	0	0	47	30	5	0	0	0	2	.488	.532	.698	1.230
24	Orioles	18	4/19/2006	BAL	vs	CLE	W 18-9	46	21	4	0	3	17	1	0	3	2	0	47	34	7	0	0	0	1	.457	.468	.739	1.207
25	Yankees	18	10/1/1980	NYY	@	CLE	W 18-7	45	19	3	0	5	16	4	0	9	1	0	51	37	8	1	1	0	1	.422	.460	.822	1.282