Preston Wilson had the most strikeouts in 2000, with 187 strikeouts.

	NAME	SO	SEASON	TM	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Preston Wilson P. Wilson	187	2000	FLA	161	605	94	160	35	3	31	121	55	8	36	14	674	294	69	0	6	1	11	.264	.331	.486	.817	94	5.4	.350	106	5.7
2	Mo Vaughn M. Vaughn	181	2000	ANA	161	614	93	167	31	0	36	117	79	14	2	0	712	306	67	0	5	11	14	.272	.365	.498	.864	111	17.2	.368	115	14.1
3	Jim Thome J. Thome	171	2000	CLE	158	557	106	150	33	1	37	106	118	4	1	0	684	296	71	0	5	4	8	.269	.398	.531	.929	124	34.6	.399	131	28.8
4	Sammy Sosa S. Sosa	168	2000	CHC	156	604	106	193	38	1	50	138	91	2	7	4	705	383	89	0	8	19	12	.320	.406	.634	1.040	146	53.4	.428	154	51.8
5	Jim Edmonds J. Edmonds	167	2000	STL	152	525	129	155	25	0	42	108	103	6	10	3	643	306	67	1	8	3	5	.295	.411	.583	.994	129	44.8	.421	149	42.6
6	Troy Glaus T. Glaus	163	2000	ANA	159	563	120	160	37	1	47	102	112	2	14	11	678	340	85	0	1	6	14	.284	.404	.604	1.008	138	49	.424	150	46
7	Richie Sexson R. Sexson	159	2000	TOT	148	537	89	146	30	1	30	91	59	7	2	0	607	268	61	0	4	2	11	.272	.349	.499	.848	92	12.4	.364	110	8.2
8	Jorge Posada J. Posada	151	2000	NYY	151	505	92	145	35	1	28	86	107	8	2	2	624	266	64	0	4	10	11	.287	.417	.527	.943	117	34.9	.405	140	33.8
9	Ray Lankford R. Lankford	148	2000	STL	128	392	73	99	16	3	26	65	70	4	5	6	472	199	45	0	6	1	6	.253	.367	.508	.874	76	14.1	.375	119	12.5
10	Dean Palmer D. Palmer	146	2000	DET	145	524	73	134	22	2	29	102	66	4	4	2	604	247	53	0	10	2	9	.256	.338	.471	.809	83	3.5	.347	104	3.2
11	Pat Burrell P. Burrell	139	2000	PHI	111	408	57	106	27	1	18	79	63	1	0	0	474	189	46	0	2	2	5	.260	.359	.463	.822	69	7.2	.358	108	4.9
12	Tim Salmon T. Salmon	139	2000	ANA	158	568	108	165	36	2	34	97	104	6	0	2	680	307	72	0	2	5	14	.290	.404	.540	.945	128	38.5	.406	138	35.5
13	Ruben Rivera R. Rivera	137	2000	SDP	135	423	62	88	18	6	17	57	44	10	8	4	479	169	41	0	2	1	8	.208	.296	.400	.696	48	-15	.305	80	-12.9
14	Geoff Jenkins G. Jenkins	135	2000	MIL	135	512	100	155	36	4	34	94	33	15	11	1	564	301	74	0	4	6	9	.303	.360	.588	.948	101	27.1	.396	132	24.4
15	Mike Cameron M. Cameron	133	2000	SEA	155	543	96	145	28	4	19	78	78	9	24	7	643	238	51	7	6	0	10	.267	.365	.438	.803	92	8	.355	110	8.5
16	Brian Daubach B. Daubach	130	2000	BOS	142	495	55	123	32	2	21	76	44	6	1	1	549	222	55	0	4	2	6	.248	.315	.448	.764	66	-5.7	.329	88	-8.9
17	Ben Grieve B. Grieve	130	2000	OAK	158	594	92	166	40	1	27	104	73	3	3	0	675	289	68	0	5	2	32	.279	.359	.487	.845	103	14.3	.365	114	13
18	Jose Cruz J. Cruz	129	2000	TOR	162	603	91	146	32	5	31	76	71	2	15	5	681	281	68	2	3	3	11	.242	.323	.466	.789	88	-1.4	.338	93	-6.2
19	J.T. Snow	129	2000	SFG	155	536	82	152	33	2	19	96	66	11	1	3	627	246	54	0	14	6	20	.284	.365	.459	.824	91	8.3	.356	110	8.5
20	Greg Vaughn G. Vaughn	128	2000	TBD	127	461	83	117	27	1	28	74	80	2	8	1	545	230	56	0	2	3	10	.254	.365	.499	.864	86	14.9	.372	116	11.8
21	Andres Galarraga A. Galarraga	126	2000	ATL	141	494	67	149	25	1	28	100	36	17	3	5	548	260	54	0	1	5	15	.302	.369	.526	.895	92	20.1	.383	124	18.2
22	Derek Bell D. Bell	125	2000	NYM	144	546	87	145	31	1	18	69	65	6	8	4	622	232	50	2	3	0	14	.266	.348	.425	.773	82	0.8	.342	101	1.1
23	Jose Hernandez J. Hernandez	125	2000	MIL	124	446	51	109	22	1	11	59	41	6	3	7	496	166	34	0	3	3	12	.244	.315	.372	.687	49	-15.9	.304	73	-18.3
24	Derrek Lee D. Lee	123	2000	FLA	158	477	70	134	18	3	28	70	63	4	0	3	546	242	49	0	2	6	14	.281	.368	.507	.875	88	16.1	.375	122	16.3
25	Eric Karros E. Karros	122	2000	LAD	155	584	84	146	29	0	31	106	63	4	4	3	663	268	60	0	12	2	18	.250	.321	.459	.780	83	-3.8	.334	99	-0.8