Chris Davis has the most career strikeouts versus the Yankees, with 230 strikeouts.

Interpreted as:

most strikeouts by a player against yankees

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Chris Davis C. Davis	230	156	538	71	120	22	0	32	89	53	8	0	0	606	238	54	0	7	6	7	.223	.299	.442	.741
2	Jimmie Foxx J. Foxx	190	302	1,077	195	326	45	20	70	246	173	2	10		1,260	621	135	8			10	.303	.400	.577	.977
3	David Ortiz D. Ortiz	175	243	894	150	271	75	1	53	171	142	3	2	0	1,055	507	129	0	16	24	28	.303	.394	.567	.961
4	Harmon Killebrew H. Killebrew	163	241	830	116	206	33	4	47	154	139	1	6	2	984	388	84	0	14	14	25	.248	.352	.467	.819
5	Reggie Jackson R. Jackson	162	176	604	92	149	25	2	37	101	87	6	10	7	705	289	64	2	6	11	16	.247	.344	.478	.823
6	Manny Ramirez M. Ramirez	158	203	733	139	236	51	0	55	165	110	10	2	3	861	452	106	0	8	25	25	.322	.413	.617	1.030
7	Dwight Evans D. Evans	158	228	752	125	189	39	7	32	118	115	3	2	7	889	338	78	8	11	5	21	.251	.348	.449	.798
8	Jimmy Dykes J. Dykes	157	333	1,193	145	308	52	17	23	147	142	14	12		1,377	463	92	28				.258	.344	.388	.732
9	Evan Longoria E. Longoria	154	172	633	93	171	30	1	35	106	69	7	5	0	719	308	66	0	10	11	22	.270	.344	.487	.830
10	Carlos Delgado C. Delgado	151	152	523	83	145	34	0	33	106	79	12	1	1	622	278	67	0	8	16	10	.277	.379	.532	.911
11	Adam Jones A. Jones	150	186	734	94	191	30	3	25	90	29	10	10	3	780	302	58	1	6	1	20	.260	.295	.411	.707
12	Jose Canseco J. Canseco	150	152	569	96	142	29	2	36	115	59	4	12	3	637	283	67	0	5	3	17	.250	.322	.497	.819
13	Larry Doby L. Doby	148	218	723	121	199	22	6	36	95	125	6	8	3	856	341	64	1	1	1	19	.275	.386	.472	.858
14	Norm Cash N. Cash	146	246	771	102	213	26	6	39	117	109	8	4	4	897	368	71	2	7	10	17	.276	.369	.477	.846
15	Jason Varitek J. Varitek	143	172	567	64	128	20	3	22	89	62	7	2	2	639	220	45	0	3	4	15	.226	.308	.388	.696
16	Carl Yastrzemski C. Yastrzemski	143	329	1,243	182	352	50	13	52	163	155	2	18	10	1,411	584	115	2	9	26	36	.283	.361	.470	.831
17	Al Simmons A. Simmons	143	304	1,202	188	374	72	12	45	231	81	7	9		1,311	605	129	21			2	.311	.358	.503	.861
18	Vic Wertz V. Wertz	140	254	851	125	231	33	7	41	182	116	6	1	4	986	401	81	6	7	3	22	.271	.360	.471	.831
19	Bob Johnson B. Johnson	139	276	1,018	152	292	48	15	36	170	140	4	15		1,165	478	99	3			12	.287	.375	.470	.845
20	Carlos Pena C. Pena	138	113	363	50	84	14	3	26	64	60	10	2	0	436	182	43	0	3	2	7	.231	.353	.501	.855
21	George Scott G. Scott	138	221	814	100	237	37	10	27	122	72	2	14	6	903	375	74	2	13	8	27	.291	.345	.461	.806
22	Boog Powell B. Powell	137	225	741	101	203	25	3	41	132	103	3	1	1	855	357	69	4	4	17	17	.274	.363	.482	.845
23	Mickey Vernon M. Vernon	136	334	1,175	136	302	48	16	38	193	145	11	13	7	1,343	496	102	10	2	3	32	.257	.344	.422	.766
24	Hank Greenberg H. Greenberg	130	190	730	144	243	63	11	53	179	93	1	10		826	487	127	2			14	.333	.409	.667	1.076
25	Xander Bogaerts X. Bogaerts	126	157	598	82	155	36	0	18	65	44	4	7	3	653	245	54	1	6	2	17	.259	.311	.410	.721

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StatMuse has game-level data for strikeouts going back to the 1916 season.

Some of the information used here was obtained free of charge from Retrosheet.

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Tue 9/16	ATL	@	WSH	9-4
Tue 9/16	ATH	@	BOS	4-5
Tue 9/16	TOR	@	TBR	1-2
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Wed 3/25	NYY	@	SFG	8:05 PM
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Chris Davis has the most career strikeouts versus the Yankees, with 230 strikeouts.

Interpreted as:

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